Stroke is among the most common reasons for disability and death. Avoiding readmissions and long lengths of stay among ischemic stroke patients has benefits for patients and health care systems alike. Although reduced readmission rates among a variety of medical patients have been associated with better nurse work environments, it is unknown how the work environment might influence readmissions and length of stay for ischemic stroke patients. Using linked data sources, we conducted a cross-sectional analysis of 543 hospitals to evaluate the association between the nurse work environment and readmissions and length of stay for 175,467 hospitalized adult ischemic stroke patients. We utilized logistic regression models for readmission to estimate odds ratios (OR) and zero-truncated negative binomial models for length of stay to estimate the incident-rate ratio (IRR). Final models accounted for hospital and patient characteristics. Seven and 30-day readmission rates were 3.9% and 10.1% respectively and the average length of stay was 4.9 days. In hospitals with better nurse work environments ischemic stroke patients experienced lower odds of 7-and 30-day readmission (7-day OR, 0.96; 95% confidence interval [CI]: 0.93-0.99 and 30-day OR, 0.97; 95% CI: 0.94-0.99) and lower length of stay (IRR, 0.97; 95% CI: 0.95-0.99). The work environment is a modifiable feature of hospitals that should be considered when providing comprehensive stroke care and improving post-stroke outcomes.ischemic stroke, length of stay, nurse work environment, readmissionGlobally, stroke is the second highest cause of death and third highest reason for disability (Benjamin et al., 2017;Gorelick, 2019). Despite acute stroke management being highly protocolized, variation still exists with regard to patient outcomes (Kaufman et al., 2019;Messé et al., 2016). For example, readmission rates among stroke patients are as high as 13% with most readmissions being unplanned and many avoidable (Bambhroliya et al., 2018;Vahidy et al., 2017).Variations in outcomes, including readmissions and length of stay, have been attributed to patient factors, including age and underlying general health (