Nutraceutical Supplements for Weight Loss

Poddar, Kavita H.; Kolge, Sanjivani; Bezman, Lena; Mullin, Gerard E.

doi:10.1177/0884533611419859

Cited by 45 publications

(43 citation statements)

References 174 publications

(348 reference statements)

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“…A recent systematic review of the current literature by the Johns Hopkins’ Weight Management Center concluded that nonprescription dietary supplements as an adjunct to weight loss currently cannot be strongly recommended. (Poddar, Kolge,2011) Furthermore, these medications have not been adequately assessed in women with PCOS.…”

Section: Obesitymentioning

confidence: 99%

Longterm management of Polycystic Ovarian Syndrome (PCOS)

Bates

Legro

2013

Molecular and Cellular Endocrinology

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Polycystic Ovarian Syndrome (PCOS) has been associated with numerous reproductive and metabolic abnormalities. Despite tremendous advances in the management of reproductive dysfunction, insight into the metabolic implications of PCOS is limited by the lack of uniform diagnostic criteria, the heterogeneity of the condition and the presence of confounders including obesity. Obesity clearly has a role in long term health and may best predict both reproductive and metabolic dysfunction as well as negatively affect the response to treatment in women with PCOS. Diabetes, cardiovascular disease and cancer are also at the forefront of any risk assessment or comprehensive treatment strategy for these women. Lifestyle modifications including dietary changes, increased exercise and weight loss are appropriate first line interventions for many women with PCOS. Pharmaceuticals including metformin, lipid lowering agents and oral contraceptives should be tailored to the individual’s risk profile and treatment goals.

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Section: Obesitymentioning

confidence: 99%

Longterm management of Polycystic Ovarian Syndrome (PCOS)

Bates

Legro

2013

Molecular and Cellular Endocrinology

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“…The growing obesity prevalence may reflect the limited potential role of public health initiatives and current pharmacological treatments for contending obesity-related cardiometabolic disorders although this issue remains a matter of debate. Therefore, there is an urgent need to discover not only new powerful drugs, but also functional foods, which may synergistically help curb the epidemic of obesity-related metabolic diseases [2, 3]. Currently, various research groups advocate the use of milk-derived proteins, including Lf, as preventive and curative tools for alleviation of complex metabolic diseases [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients

et al. 2016

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ContextLactoferrin (Lf) is an important protein found on mucosal surfaces, within neutrophils and various cells, and in biological fluids. It displays multiple functions, including iron-binding as well as antimicrobial, immunomodulatory and anti-inflammatory activities. Although Lf ingestion has been suggested to cause adiposity reduction in murine models and humans, its relationship with insulin resistance (IR) has not been studied thoroughly.ObjectiveTo establish the association between circulating Lf levels, glucose status and blood lipid/lipoprotein profile.MethodsTwo independent cohorts were examined: lean to moderately obese women admitted for gynecological surgery (n = 53) and severely obese subjects undergoing biliopancreatic diversion (n = 62).ResultsAlthough body mass index (BMI) and total body fat mass were negatively associated with Lf, IR (assessed by the HOMA-IR index) was positively and independently associated with plasma Lf concentrations of the first cohort of lean to moderately obese women. These observations were validated in the second cohort in view of the positive correlation between plasma Lf concentrations and the HOMA-IR index, but without a significant association with the body mass index (BMI) of severely obese subjects. In subsamples of severely obese subjects matched for sex, age and BMI, but with either relatively low (1.89 ± 0.73) or high (13.77 ± 8.81) IR states (according to HOMA-IR), higher plasma Lf levels were noted in insulin-resistant vs insulin-sensitive subjects (P<0.05). Finally, Lf levels were significantly higher in lean to moderately obese women than in severely obese subjects (P<0.05).ConclusionOur findings revealed that plasma Lf levels are strongly associated with IR independently of total adiposity, which suggests an intriguing Lf regulation mechanism in conditions of obesity and IR.

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“…We captured all pages available from each program’s website between June 6 and June 11, 2014. We developed a coding scheme based upon 2013 AHA/ACC/TOS weight management guidelines (5) and prior reviews on efficacy of prescription medications and supplements for weight loss (15-16) to identify relevant content (Supporting Information S1). We considered supplements to include dietary supplements, nutraceuticals, or other products that are not approved by the Food and Drug Administration (FDA) in the treatment of obesity (e.g., vitamins, minerals, herbal, botanicals, amino acids, enzymes, hormones, etc).…”

Section: Methodsmentioning

confidence: 99%

Guideline‐concordant weight‐loss programs in an urban area are uncommon and difficult to identify through the internet

Bloom

Mehta

Clark

et al. 2016

Obesity

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Objective To determine the reliability of Internet-based information on community-based weight-loss programs and grade their degree of concordance with 2013 American Heart Association, American College of Cardiology, and The Obesity Society weight management guidelines. Methods We conducted an online search for weight-loss programs in the Maryland-Washington, DC-Virginia corridor. We performed content analysis to abstract program components from their websites, and then randomly selected 80 programs for a telephone survey to verify this information. We determined reliability of Internet information in comparison with telephone interview responses. Results Of the 191 programs, we graded 1% as high, 8% as moderate, and 91% as low with respect to guideline concordance based on website content. Fifty-two programs participated in the telephone survey (65% response rate). Program intensity, diet, physical activity, and use of behavioral strategies were underreported on websites as compared to description of these activities during phone interview. Within our subsample, we graded 6% of programs as high based on website information, whereas we graded 19% as high after telephone interview. Conclusions Most weight-loss programs in an urban, mid-Atlantic region do not currently offer guideline-concordant practices and fail to disclose key information online, which may make clinician referrals challenging.

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Nutraceutical Supplements for Weight Loss

Cited by 45 publications

References 174 publications

Longterm management of Polycystic Ovarian Syndrome (PCOS)

Longterm management of Polycystic Ovarian Syndrome (PCOS)

Plasma Lactoferrin Levels Positively Correlate with Insulin Resistance despite an Inverse Association with Total Adiposity in Lean and Severely Obese Patients

Guideline‐concordant weight‐loss programs in an urban area are uncommon and difficult to identify through the internet

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