Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

Poli, Andrea; Barbagallo, Carlo M.; Cicero, Arrigo Francesco Giuseppe; Corsini, Alberto; Manzato, Enzo; Trimarco, Bruno; Bernini, Franco; Visioli, Francesco; Bianchi, Alfio; Canzone, Giuseppe; Crescini, Claudio; Kreutzenberg, Saula de; Ferrara, Nicola; Gambacciani, Marco; Ghiselli, Andrea; Lubrano, Carla; Marelli, Giuseppe; Marrocco, Walter; Montemurro, Vincenzo; Parretti, Damiano; Pedretti, Roberto F.E.; Perticone, Francesco; Stella, Roberto; Marangoni, Franca

doi:10.1016/j.phrs.2018.05.015

Cited by 129 publications

(89 citation statements)

References 70 publications

(76 reference statements)

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“…This can cause bloating and intestinal distress ranging from diarrhea to constipation (if water intake is inadequate). Co-administration of drugs also calls for caution because fiber can sequester active molecules and alter (usually decrease) bioavailability (Poli et al 2018;Poli and Visioli 2019). Patients should be told to avoid such practice and to get used to fiber gradually.…”

Section: Untoward Effectsmentioning

confidence: 99%

“…Because of (a) the severe impact of CVD in terms of mortality, morbidity, quality of life, and economy, (b) the proved role of LDL plasma levels as the most critical risk factor among a large collection of others, and (c) the obstacles found both in terms of biological effects and compliance of the patient by an exclusively dietary intervention, food supplements or nutraceuticals deserve an in-depth analysis because they are valuable resources for physicians (Poli et al 2018;Poli and Visioli 2019). As regards cholesterol control, several preparations are available in the market, and we will critically review them in this chapter.…”

Section: Introductionmentioning

confidence: 99%

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Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Visioli¹,

Poli²

2019

Handbook of Experimental Pharmacology

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Nutritional interventions are effective and – in theory – easy to implement primary and secondary prevention strategies that reduce several risk factors of atherosclerosis and cardiovascular disease (CVD). Yet, because of (a) the severe impact of CVD in terms of mortality, morbidity, quality of life, and economy, (b) the proved role of LDL plasma concentrations as the most critical risk factor, and (c) the obstacles found both in terms of biological effects and compliance of the patient by an exclusively dietary intervention, food supplements or nutraceuticals are now valuable resources for physicians. As regards cholesterol control, several preparations are available in the market, and we will critically review them in this chapter.

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Section: Untoward Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Visioli¹,

Poli²

2019

Handbook of Experimental Pharmacology

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“…Berberine does not modify CPK [68], while for ezetimibe the incidence of myopathy/rhabdomyolysis was identical (0.2%) to that found in placebo patients. PCSK9 inhibitors may be used in myopathic patients at high cardiovascular risk.…”

Section: Discussionmentioning

confidence: 62%

Polymyositis, Dermatomyositis, and Statins: A Review

Turrin

2019

CMI

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BACKGROUND: Statins are a well-recognized cause of a variety of skeletal myopathic effects, which generally resolve when discontinuing the treatment. Among autoimmune manifestations associated with statins, there are typical polymyositis (PM) and typical dermatomyositis (DM). OBJECTIVE: To perform a review on published case reports and case series about statin-associated PM and DM. METHODS: This literature comprehensive search was conducted mainly on PubMed, but also congress abstracts and university websites were considered. Given the paucity of cases, the search was extended to include articles in all languages with English abstract. RESULTS: Twenty-eight PM and 30 DM cases have been described with prevalence in female (64%) and senile age. The drugs most frequently involved were atorvastatin and simvastatin. The differential diagnosis should be made among the main myositis subtypes: immuno-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and overlap syndrome with myositis (OM), including anti-synthetase syndrome (ASS). CONCLUSIONS: Even though the onset of polymyositis or dermatomyositis is a rare phenomenon, it is advisable to consider their presence in patients taking statins and with a non-reversible elevation of creatine phosphokinase. Polimiosite, dermatomiosite e statine: una reviewCMI 2018; 12(1): 89-102 https://doi.org/10.7175/cmi.v12i1.1364

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“…Plant sterols and stanols (Jones et al ., ); monacolin K (Castelnuovo et al ., ; Mazza et al ., ,b), red yeast rice (Cicero, ) and beta‐glucans (Stancu et al ., ; Suchecka et al ., ; Tamura et al ., ; Tessari & Lante, ), have been shown to reduce plasma cholesterol. Modification of plasma LDL‐cholesterol is causally associated with cardiovascular risk factors (Berryman et al ., ; Gisterå & Hansson, ; Poli et al ., ). These compounds can inhibit the intestinal absorption of cholesterol from both food and bile in a dose‐dependent manner (Poli et al ., ), however, phytosterols also reduce absorption of carotenoids and fat‐soluble vitamins.…”

Section: Evolution Of the Meaning Of Functional Foodmentioning

confidence: 97%

Ensuring the future of functional foods

Birch

Bonwick

2018

Int J of Food Sci Tech

129

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Consumption of functional foods suggests a strategy to reduce the incidence of chronic health disorders. This message has resonated with consumers and driven market growth. Functional food research has significantly increased over the last decade but few studies have addressed the bioavailability of active ingredients for clinical efficacy. Baked goods such as bread, biscuits and cake are popular categories for innovation due to their widespread consumption. These new developments have often impacted on organoleptic properties of the finished products and thus consumer acceptance. Blending of bioactive ingredients may overcome this deficit. However, an understanding of the role of the microbiome in health has indicated that the efficacy of functional foods is unlikely to be uniform within the population. Further growth in the functional foods market, is likely to require greater evidence of the bioavailability of active ingredients, clinical effect and support for health claims by regulators especially in the EU.

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Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

Cited by 129 publications

References 70 publications

Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods

Polymyositis, Dermatomyositis, and Statins: A Review

Ensuring the future of functional foods

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