Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol

Zlotogorski, Ayelet; Dayan, Aliza; Dayan, Dan; Chaushu, Gavriel; Salo, Tuula; Vered, Marilena

doi:10.1016/j.oraloncology.2013.02.011

Cited by 38 publications

(19 citation statements)

References 51 publications

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“…Therefore, EGCG and TF would be perfect candidates for this type of treatment. Despite the enormous number of studies done on cancer therapy using EGCG [20, 24–26] or TF [17, 27, 28], surprisingly there are no reports on the synergistic effects of these polyphenols on cancer cells. In our research we chose the concentration of 20 μg/ml for both polyphenols as this concentration had a weak anticancer effect for both compounds individually.…”

Section: Resultsmentioning

confidence: 99%

Experimental immunology Synergistic anticancer activity of biologicals from green and black tea on DU 145 human prostate cancer cells

Kobalka¹,

Keck²,

Jankun³

2015

cejoi

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There is considerable interest in the potential of botanicals in preventing and/or alleviating chronic ailments. Among the most studied botanicals are compounds present in green and black teas. Nontoxic tea polyphenols are potent antioxidants, and they also modulate several signalling pathways and inhibit proteins such as MMP-9 or protein plasminogen activator system, making them very attractive potential therapeutics. One criticism of the prophylactic or therapeutic use of green or black tea polyphenols was presumably the poor bioavailability of these chemicals when ingested. However, studies have shown that epigallocatechin-3-gallate (EGCG) and theaflavin (TF) can be detected in the small and large intestine, liver, and prostate of experimental animals after consumption of tea extracts. In particular, a study was carried out on 20 men scheduled for prostatectomy, who were assigned to consume teas for five days before surgery. Tea polyphenols were detected in the prostate. This fact contradicts the common misconception of poor bioavailability of TF and EGCG and makes feasible the application of green or black tea polyphenols as prophylactic and therapeutic agents. Theaflavins and catechins seem to act on cancer cells largely through different pathways, so utilisation of both could offer synergistic anticancer effects, but so far no work has been done on the cumulative effects of EGCG and TF on prostate cancer. Therefore, in this study we have investigated if EGCG in combination with TF can reduce the rate of prostate cancer growth, and we have observed greater cell death compared to application of either TF or EGCG alone.

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Section: Resultsmentioning

confidence: 99%

Experimental immunology Synergistic anticancer activity of biologicals from green and black tea on DU 145 human prostate cancer cells

Kobalka¹,

Keck²,

Jankun³

2015

cejoi

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“…It is obtained from the non-fermented leaves of the Camellia sinensis plant. It has promising health beneficial effects and it is considered as one of the most important nutraceuticals that used as new treatment approaches for oral cancer [48]. The polyphenols of GT (GTP), particularly catechin ( −) epigallocatechin-3-gallate (EGCG), which has about 50-80% of the total catechins in GT, is reported to have an antioxidant effect [49].…”

Section: Green Tea-drug Interactionmentioning

confidence: 99%

Food–drug Interaction and Their Clinical Implications: Selected Investigations

Elgadir

2019

Int J Pharm Pharm Sci

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Food-drug interactions occur as a result of pharmacokinetic or pharmacodynamics mechanisms. Pharmacokinetic mechanisms include what the body does to a drug while Pharmacodynamics mechanisms involve what drugs do to the body. Many types of food have been shown to influence metabolism and the absorption of drugs. Large numbers of drugs are produced and introduced yearly. The interaction between Food and drug may cause negative effects in the nutritional status of the patient as well as safety and efficacy of drug therapy. Due to the possibility of unexpected or poor outcomes, generally, food-drug interactions, in this case, should be avoided. As the good clinical practice, drugs taken by mouth must be absorbed either through the lining of the stomach or the small intestine. Reduction in the absorbance of a drug might be influenced by the presence of food in the digestive tract. The avoidance of such interactions could be possible if the drug is taken 1 hour before or 2 h after eating the food. The effects of several types of food such as milk or milk products, grapefruit and grapefruit juice, bananas, oranges, legumes, fermented meats and pickled fish and some nutrient elements such as calcium, potassium, magnesium, iron, zinc, and vitamin K are highlighted in this paper including their clinical implications.

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“…Similar to CUR, RES may have partial biological activity due to poor absorption and first-pass metabolism [ 16 , 17 ]. It has been reported that RES and CUR inhibit the growth of HNSCC cell lines when employed as single drugs [ 18 - 25 ]. Overall, the poor bioavailability of CUR and RES will affect the effective dose delivered to cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

et al. 2014

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The survival rate of head and neck squamous cell carcinomas (HNSCC) patients has not considerably changed over the last two decades. Polyphenols inhibit the growth of cancer cells. We determined whether the combination of Resveratrol (RES) and Curcumin (CUR) enhanced their in vitro and in vivo antitumor activities on HNSCC cell lines compared to the single compounds. We provide evidence that RES potentiated the apoptotic effect and reduced the IC50 of CUR on HNSCC cell lines. The model of compounds interaction indicated the onset of an additive effect of the two compounds compared to the single treatment after decrease of their concentrations. RES+CUR compared to CUR increased the PARP-1 cleavage, the Bax/Bcl-2 ratio, the inhibition of ERK1 and ERK2 phosphorylation, and the expression of LC3 II simultaneously with the formation of autophagic vacuoles. RES and CUR induced cytoplasmic NF-κB accumulation. RES+CUR administrations were safe in BALB/c mice and reduced the growth of transplanted salivary gland cancer cells (SALTO) more efficiently than CUR. Overall, combinations of CUR and RES was more effective in inhibiting in vivo and in vitro cancer growth than the treatment with CUR. Additional studies will be needed to define the therapeutic potential of these compounds in combination.

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Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol

Cited by 38 publications

References 51 publications

Experimental immunology Synergistic anticancer activity of biologicals from green and black tea on DU 145 human prostate cancer cells

Experimental immunology Synergistic anticancer activity of biologicals from green and black tea on DU 145 human prostate cancer cells

Food–drug Interaction and Their Clinical Implications: Selected Investigations

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

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