2014
DOI: 10.18632/oncotarget.2534
|View full text |Cite
|
Sign up to set email alerts
|

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

Abstract: The survival rate of head and neck squamous cell carcinomas (HNSCC) patients has not considerably changed over the last two decades. Polyphenols inhibit the growth of cancer cells. We determined whether the combination of Resveratrol (RES) and Curcumin (CUR) enhanced their in vitro and in vivo antitumor activities on HNSCC cell lines compared to the single compounds. We provide evidence that RES potentiated the apoptotic effect and reduced the IC50 of CUR on HNSCC cell lines. The model of compounds interaction… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
75
0
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
9
1

Relationship

2
8

Authors

Journals

citations
Cited by 93 publications
(79 citation statements)
references
References 62 publications
3
75
0
1
Order By: Relevance
“…Initiator caspases such as caspase 8 and caspase 9, which cleave inactive pro‐forms of effector caspases, were evaluated in eight included studies. Effector caspase 3 and caspase 7 were evaluated in 12 included studies . The intrinsic or mitochondrial apoptotic pathway is mostly controlled by members of the Bcl‐2 family, which may act as inhibitors or promoters of apoptosis .…”
Section: Discussionmentioning
confidence: 99%
“…Initiator caspases such as caspase 8 and caspase 9, which cleave inactive pro‐forms of effector caspases, were evaluated in eight included studies. Effector caspase 3 and caspase 7 were evaluated in 12 included studies . The intrinsic or mitochondrial apoptotic pathway is mostly controlled by members of the Bcl‐2 family, which may act as inhibitors or promoters of apoptosis .…”
Section: Discussionmentioning
confidence: 99%
“…Equal loading of protein was verified by Ponceau staining of the membranes and by analyzing actin expression. The assay was then performed as previously described [47].…”
Section: Western Blottingmentioning
confidence: 99%
“…However, low bioavailability of these agents limits their therapeutic application, and the concentrations needed for retardation of tumor growth in rodents greatly exceed doses compatible with human use [2729]. The utilization of the ability of polyphenols to synergistically enhance anticancer effects of one another in different models [3033] has been suggested, among other approaches [28, 34], to improve their bioactivity in vivo . Using this combination strategy, we have previously shown that CUR and another polyphenol, carnosic acid (CA), combined at potentially bioavailable non-cytotoxic concentrations of each agent robustly triggered apoptosis in KG-1a and HL60 AML cells [35].…”
Section: Introductionmentioning
confidence: 99%