Nutraceuticals for Blood Pressure Control in Patients with High-Normal or Grade 1 Hypertension

Trimarco, Valentina; Cimmino, Claudia Sara; Santoro, M Giannotti; Pagnano, Gianpiero; Manzi, Maria Virginia; Piglia, Anna; Giudice, Caterina Anna; Luca, Nicola De; Izzo, Raffaele

doi:10.1007/bf03262460

Cited by 15 publications

(19 citation statements)

References 21 publications

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“…Yin et al reported that approximately 34.5% of patients treated with berberine (500 mg three times daily) experienced transient adverse gastrointestinal effects . Moreover, berberine can lower blood sugar levels and blood pressure and should, therefore, be used with caution in people with diabetes or low blood pressure . Berberine is a potent displacer of bilirubin when tested in vitro using plasma from jaundiced new‐born babies and, therefore, poses a risk of kernicterus .…”

Section: Tolerability and Safetymentioning

confidence: 99%

Pharmacological effects of berberine on mood disorders

Fan

Zhang

Jin

et al. 2018

J Cellular Molecular Medi

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Berberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been shown to have efficacy in the treatment of mood disorders. Furthermore, berberine modulates neurotransmitters and their receptor systems within the central nervous system. However, the detailed mechanisms of its action remain unclear. This review summarizes the pharmacological effects of berberine on mood disorders. Therefore, it may be helpful for potential application in the treatment of mood disorders.

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Section: Tolerability and Safetymentioning

confidence: 99%

Pharmacological effects of berberine on mood disorders

Fan

Zhang

Jin

et al. 2018

J Cellular Molecular Medi

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“…Coenzyme Q10 has consistent and significant antihypertensive effects in patients with essential hypertension . Compared with normotensive patients, essential hypertensive patients have a higher incidence (6‐fold) of coenzyme Q10 deficiency documented by serum levels . Doses of 120 mg/d to 225 mg/d of coenzyme Q10 are necessary to achieve a therapeutic level of 3 μg/mL .…”

Section: Coenzyme Q10 (Ubiquinone)mentioning

confidence: 99%

“…Compared with normotensive patients, essential hypertensive patients have a higher incidence (6‐fold) of coenzyme Q10 deficiency documented by serum levels . Doses of 120 mg/d to 225 mg/d of coenzyme Q10 are necessary to achieve a therapeutic level of 3 μg/mL . This dose is usually 3 mg/kg/d to 5 mg/kg/d of coenzyme Q10.…”

Section: Coenzyme Q10 (Ubiquinone)mentioning

confidence: 99%

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Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part III

Houston

2013

J of Clinical Hypertension

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Vascular biology, endothelial and vascular smooth muscle, and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease, and target organ damage. Nutrient‐gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control, and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation, and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension based on scientifically controlled studies that complement optimal nutrition, coupled with other lifestyle modifications.

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“…Another important characteristic of AuNPs is the ability of dissipating heat when absorbing light, being an interest approach for thermal therapy as a trigger to release of encapsulated drugs from thermosensitive hydrogels [9] [17]. Moreover, there are no reports on the use of BS for preparing crosslinked AuNPs hydrogel nanocomposites, despite its relevance in the context of new formulations for biocompatible hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

Souza¹,

Oliveira²,

Pinheiro³

et al. 2015

JBNB

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In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and Japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%); gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel. * Corresponding authors. C. Rufino Souza et al.54

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Nutraceuticals for Blood Pressure Control in Patients with High-Normal or Grade 1 Hypertension

Abstract: Our results show that the addition of Orthosiphon stamineus to the combination of nutraceuticals confers an antihypertensive effect that allows a surprisingly effective 24-hour BP control in hypertensive patients.

Cited by 15 publications

References 21 publications

Pharmacological effects of berberine on mood disorders

Pharmacological effects of berberine on mood disorders

Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part III

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

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