Nutraceuticals in dyslipidemia management

Kota, Sunil Kumar; Jammula, Sruti; Kota, Siva Krishna; Krishna, Surabhi Venkata Satya; Meher, Lalit Kumar; Rao, Epari Sanjeeva; Modi, Kirtikumar D

doi:10.4103/2278-019x.105328

Cited by 10 publications

(7 citation statements)

References 5 publications

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“…Pretreatment with EEOT decreases the levels of serum total cholesterol, TGs, LDL-C, VLDL-C, and elevated HDL-C concentration. Recently, it has been reported that neutraceutical supplements can significantly reduce LDL-C, decrease TGs, and increase HDL-C [ 36 ]. The protective effect observed in this study may be due to the potent antioxidant property of the extract of Citrus medica , which protects cardiac muscle from the oxidative damage and helps in maintaining the myocardial cell membrane integrity and function thereby protecting the rupture and preventing leakage of the enzyme and lipids [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Citrus medica “Otroj”: Attenuates Oxidative Stress and Cardiac Dysrhythmia in Isoproterenol-Induced Cardiomyopathy in Rats

et al. 2013

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Citrus medica L. commonly known as Otroj, is an important medicinal plant reputed for its nutritious and therapeutic uses. The present work was undertaken to investigate the protective effect of the ethanolic extract of otroj (EEOT) against isoproterenol (ISO)-induced cardiotoxicity in rats. In addition, the antioxidant activity and the phenolic and flavonoidal contents were determined. Rats were administered EETO (250 and 500 mg/kg) or vehicle orally for 15 days along with ISO (85 mg/kg, s.c.) on the 14th and 15th day. ISO induced cardiac dysfunction, increased lipid peroxidation and alteration of myocyte-injury specific marker enzymes. ISO also showed an increase in levels of plasma cholesterol, triglycerides (TG), LDL-C, and VLDL-C. Moreover, the histological investigations showed myocardial necrosis and inflammation. EETO treatment brought the above parameters towards normal level. Moreover, in vitro DPPH radical scavenging and β-carotene-linoleic acid tests of the EEOT exhibited a notable antioxidant activity in both assays used. In addition, histopathological examination reconfirmed the protective effects of EEOT. Thus, the present study reveals that C. medica alleviates myocardial damage in ISO-induced cardiac injury and demonstrates cardioprotective potential which could be attributed to its potent antioxidant and free radical scavenging activity.

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Section: Discussionmentioning

confidence: 99%

Citrus medica “Otroj”: Attenuates Oxidative Stress and Cardiac Dysrhythmia in Isoproterenol-Induced Cardiomyopathy in Rats

et al. 2013

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“…The presence of γ-oryzanol (cycloartenol), a ferulate ester of triterpene alcohol with a similar structure to cholesterol, may compete with the binding sites of cholesterol, thereby impaired uptake of cholesterol into enterocytes by withdrawal cholesterol from the system [51]. Oryzanol has an effect on lowering plasma non-HDL-C and raising plasma HDL through a greater extent to increase fecal excretion of cholesterol and its metabolites [1].…”

Section: Rbomentioning

confidence: 99%

“…The increasing worldwide prevalence of diabetes mellitus increases the risk of heart disease and stroke. This will substantially increase burden of cardiovascular death rate morbidity and mortality due to atherosclerotic heart disease [1]. The World Health Organization (WHO) estimates that CVD will continue to dominate mortality trends in the future and in 2015, there will be about 20 million CVD deaths [2].…”

Section: Introductionmentioning

confidence: 99%

Rice Bran Oil Compared to Atorvastatin for Treatment of Dyslipidemia in Patients with Type 2 Diabetes

Shakib¹,

Gabrial²,

Gabrial³

2014

Open Access Maced J Med Sci

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Objective: To compare the effect of rice bran oil versus statins (atorvastatin drug) on blood glucose, glycosylated hemoglobin (HbA1C) and serum lipid profiles in patients with type 2 diabetes. The safety of the tested rice bran oil and atorvastatin were investigated. Fatty acids contents of RBO, olive and sesame oil were also assessed.Materials and Methods: Forty four eligible patients with type 2 diabetes and moderately hyperlipidemic were randomly and equally allocated into two groups, rice bran oil (RBO) group and atorvastatin group. The RBO group received a low-calorie diet and consumed 30 g / day RBO oil as salad dressing and for use as main cooking oil for 6 months. The Atorvastatin group received a low-calorie diet and 40 mg/day of atorvastatin drug for 6 months. At baseline and after 6 months of study intervention, blood glucose, glycosylated hemoglobin (HbA1c), serum lipid profiles; hepatic, renal and inflammatory biomarkers were estimated.Results: Results showed significant increase in fasting and postprandial blood glucose, HbA1C and liver transaminases (alanine transaminase ALT and aspartate transaminase AST) in the atorvastatin group while a significant reduction was shown in RBO group. Moreover, significant reductions in lipid profile levels, blood urea, serum uric acid and erythrocyte sedimentation rate (ESR) were observed in both RBO and atorvastatin groups after 6 months of the study intervention.Conclusion: The use of rice bran oil together with dietary modifications may have implications in lowering fasting and postprandial blood glucose, suppressing serum lipid levels, reduce the TC/HDL-C ratio and therefore reducing the risk of cardiovascular disease. Moreover, RBO exerts a hypouricemic action and anti-inflammatory effects. The findings obtained from the current study reinforce the use of RBO as an alternative natural potent hypolipidemic agent safer than atorvastatin drug that may induce side effects in some cases in patients intolerant to statins

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“…[91] In vitro displacement of PON1 by human apo A-II at physiological concentrations could explain the observation that PON1 was mostly found in HDL particles containing apo A-I but not apo A-II, and thus the lack of anti-atherogenic properties of apo A-II–enriched HDL. [9293] Studies have demonstrated susceptibility of HDL to atherogenic modifications like glycation and homocysteinylation, induced in vitro in the absence of PON1 activity. [9495] Zech et al .…”

Section: Paraoxonase 1 Activity In Dyslipidemiamentioning

confidence: 99%

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Kota

Meher

Kota

et al. 2013

Indian J Endocr Metab

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Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL toward protection of lipoprotein and biological membrane against oxidative damage. It may have a protective role against atherosclerosis by virtue of its action on hydrolyzing lipid peroxides and preventing accumulation of phospholipids in oxidized low-density lipoprotein (LDL). PON1 is hypothesized to be an indicator of the risk of atherosclerosis and coronary artery disease development. Numerous studies have implicated PON1 activity in relation to various endocrine disorders. The current article reviews the clinical perspectives of PON1 activity with regards to obesity, diabetes mellitus with its complications, and dyslipidemia.

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Nutraceuticals in dyslipidemia management

Cited by 10 publications

References 5 publications

Citrus medica “Otroj”: Attenuates Oxidative Stress and Cardiac Dysrhythmia in Isoproterenol-Induced Cardiomyopathy in Rats

Citrus medica “Otroj”: Attenuates Oxidative Stress and Cardiac Dysrhythmia in Isoproterenol-Induced Cardiomyopathy in Rats

Rice Bran Oil Compared to Atorvastatin for Treatment of Dyslipidemia in Patients with Type 2 Diabetes

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

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