Nutraceuticals in pathogenic obesity; striking the right balance between energy imbalance and inflammation

Kota, Sunil Kumar; Jammula, Sruti; Kota, Siva Krishna; Krishna, Surabhi Venkata Satya; Meher, Lalit Kumar; Rao, Epari Sanjeeva; Modi, Kirtikumar D

doi:10.4103/2278-019x.101288

Cited by 11 publications

(6 citation statements)

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“…Obesity is associated with several alterations in the lipid metabolism, leading to changes in lipoprotein levels and composition,[3334] and greater risk of cardiovascular disease. Oxidative stress is increased in obese subjects compared with healthy controls[35] Figure 3.…”

Section: Paraoxonase 1 Activity In Obesitymentioning

confidence: 99%

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Kota

Meher

Kota

et al. 2013

Indian J Endocr Metab

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Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL toward protection of lipoprotein and biological membrane against oxidative damage. It may have a protective role against atherosclerosis by virtue of its action on hydrolyzing lipid peroxides and preventing accumulation of phospholipids in oxidized low-density lipoprotein (LDL). PON1 is hypothesized to be an indicator of the risk of atherosclerosis and coronary artery disease development. Numerous studies have implicated PON1 activity in relation to various endocrine disorders. The current article reviews the clinical perspectives of PON1 activity with regards to obesity, diabetes mellitus with its complications, and dyslipidemia.

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Section: Paraoxonase 1 Activity In Obesitymentioning

confidence: 99%

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Kota

Meher

Kota

et al. 2013

Indian J Endocr Metab

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“…A nutraceutical is a food containing health-promoting ingredients or natural components that may provide desirable health benefits and contribute to the prevention of chronic diseases [ 5 ]. It has been suggested that nutraceuticals have the potential to regulate imbalances between energy intake and output and to ameliorate the development of oxidative stress and inflammation in obesity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

et al. 2015

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BACKGROUND/OBJECTIVESWe investigated the effects of a combination of grape pomace (Vitis labrusca, Campbell Early) and Omija fruit (Schizandra chinensis, Baillon) ethanol extracts on lipid metabolism and antioxidant defense system in diet-induced obese mice.MATERIALS/METHODSForty male C57BL/6J mice were divided into four groups and fed high-fat diet (control group, CON) or high-fat diet added 0.5% grape pomace extract (GPE), 0.05% Omija fruit extract (OFE) or 0.5% GPE plus 0.05% OFE (GPE+OFE) for 12 weeks.RESULTSIn contrast to the GPE- or OFE-supplemented groups, the GPE+OFE group showed significantly lower body weight and white adipose tissue weights than the CON group. Moreover, GPE+OFE supplementation significantly decreased plasma total cholesterol and increased the plasma HDL-cholesterol/total-cholesterol ratio (HTR) compared to the control diet. The hepatic triglyceride level was significantly lower in the GPE+OFE and GPE groups by increasing β-oxidation and decreasing lipogenic enzyme compared to the CON group. Furthermore, GPE+OFE supplementation significantly increased antioxidant enzyme activities with a simultaneous decrease in liver H2O2 content compared to the control diet.CONCLUSIONSTogether our results suggest that supplementation with the GPE+OFE mixture may be more effective in improving adiposity, lipid metabolism and oxidative stress in high-fat diet-fed mice than those with GPE and OFE alone.

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“…Therefore, continuous research is being conducted to develop safe and effective therapies to treat obesity. In this context, the development of natural product-based medication or nutraceuticals is gaining importance because their minimal side effects and maximal efficiency [8,9]. Hyaluronan is a major component of ECM and is widely used in pharmaceutical and medical applications, such as arthritis treatment [18], ophthalmic surgery [19,20], drug delivery [21], and tissue engineering [22], owing to its unique physicochemical properties and various biological functions.…”

Section: Discussionmentioning

confidence: 99%

“…Although several drugs have been developed to treat obesity, no ideal compounds or drugs have been developed yet [7]. Because diets containing high-fat foods are becoming common, there is a need to find suitable alternatives to ameliorate the effects of a high-fat diet, thereby decreasing the risk associated with obesity [8,9].…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice

Park

et al. 2016

Biochemical and Biophysical Research Communications

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Nutraceuticals in pathogenic obesity; striking the right balance between energy imbalance and inflammation

Cited by 11 publications

References 0 publications

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia

Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice

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