Nutraceuticals in Sports Activities and Fatigue

Гончаров, Н. В.; Maevsky, Eugene I.; Voitenko, Natalia; Novozhilov, A. V.; Кубасов, И. В.; Jenkins, Richard O.; Avdonin, P. V.

doi:10.1016/b978-0-12-802147-7.00014-0

Cited by 15 publications

(7 citation statements)

References 101 publications

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“…Antioxidant supplementation has been demonstrated to exert adverse effects, especially on adaptation to intense training [247,248]. These antioxidants can actually reduce the level of oxidative stress molecules, though this "improvement" often has no correlation with adaptation to strenuous exercise, and many antioxidant-based clinical trials and therapeutic interventions have been largely disappointing in their therapeutic benefit [249,250]. At the same time, some natural metabolites (pyruvate, ethylpyruvate, fructose-1,6-bisphosphate, etc.)…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

“…At the same time, some natural metabolites (pyruvate, ethylpyruvate, fructose-1,6-bisphosphate, etc.) or nutraceuticals taken exogenously as food additives 16 Oxidative Medicine and Cellular Longevity or separately can effectively neutralize oxidative stress, improve health, and even enhance adaptation to physical stress [250,251]. An important prerequisite of the new concept in redox biology/medicine is the use of compounds that has been termed "pathologically activated therapeutics," that is, relatively small molecules that are chemically converted to their active form by the very oxidative stress which they are intended to combat [252].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

“…Nevertheless, oxygen is not always available in plenty amounts, for example, in ischemic states. In such cases, some artificial or natural electrophiles (electron acceptors) could be helpful, and this property has been exploited for elaborating a new type of therapeutics with the help of OSC, polyphenols, and other nutraceuticals [250,253]. Nutraceuticals could serve not only as electrophiles, but also as a kind of "pro-electrophilic drugs" that become electrophilic in response to oxidation with subsequent activation of the Keap1/Nrf2/ARE transcription pathway and synthesis of endogenous antioxidant "phase 2" enzymes [252].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

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Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

167

115

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Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic vessels, thus forming an interface between the tissues and the blood or lympha. This strategic position of endothelium infers its indispensable functional role in controlling vasoregulation, haemostasis, and inflammation. The state of endothelium is simultaneously the cause and effect of many diseases, and this is coupled with modifications of endothelial phenotype represented by markers and with biochemical profile of blood represented by biomarkers. In this paper, we briefly review data on the functional role of endothelium, give definitions of endothelial markers and biomarkers, touch on the methodological approaches for revealing biomarkers, present an implicit role of endothelium in some toxicological mechanistic studies, and survey the role of reactive oxygen species (ROS) in modulation of endothelial status.

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Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

167

115

View full text Add to dashboard Cite

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“…Nutraceuticals are an area of recent research in which substances not traditionally associated with nutrients or drugs show physiological effect on the body [96]. The nutraceutical era is an emerging opportunity to find the inherent nutritional value in biology (like the functional value of amaranth discussed in this book) and requires an additional effort in its research to conduct robust and controlled clinical trials to throw light on the knowledge field.…”

Section: Further Research In the Sports Field Of Amaranth 41 Clinicamentioning

confidence: 99%

Functional Value of Amaranth as Applied to Sports Nutrition

Torregrosa-García¹,

Javier²

2020

Nutritional Value of Amaranth

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Amaranth can be beneficial to health and sports, with multiple applications owing to varied concentration of phytochemical; the concentration of these compounds depends on the part or by-product employed. For example, as a food supplement, amaranth oil (rich in squalene) can exert cardiovascular properties, while amaranth extract (rich in nitrites) can increase nitric oxide production (therefore improving endurance performance). On the other hand, as a functional ingredient, its gluten-free flours (containing fibre) can act as probiotics, whereas its proteins (with a peculiar amino acid profile) support muscle recovery. The few clinical results with athletic population suggest it can contribute to improved aerobic metabolism, but there is insufficient clinical data to draw any conclusion. Further research warrants elucidation of amaranth phytochemicals as promising ergogenic aids in sports by high-quality human clinical trials with both standardised products and ingredients in athletic population.

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“…With the accumulation of lactic acid and ammonia (metabolites), the depletion of blood glucose and tissue glycogen is the prime motivator for peripheral fatigue. Continuous supply of energy resources and the elimination of metabolites are able to alleviate peripheral fatigue (Goncharov et al., 2016). Fatigue may lead to aging, cancer, depression, multiple sclerosis, Parkinsonian syndrome, and other diseases, which affected more than one‐fifth of people worldwide (Hsiao et al., 2018; Narkhede et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Antifatigue effect of functional cookies fortified with mushroom powder (Tricholoma Matsutake) in mice

Hongling

et al. 2020

Journal of Food Science

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Bakery products made by cereal and edible fungi powder have a unique flavor and health benefits, dramatically enhancing the nutritional value of the products. In this study, we investigated the antifatigue effect of a novel Tricholoma matsutake cookie (TMC) by the exhaustive swimming test. Male Kunming ICR mice were randomly divided into seven groups (each group, n = 10), fed with saline, ordinary cookies (4, 8, 16 g/kg B.W./day), and TMC (4, 8, 16 g/kg B.W./day) by gavage. After 30-day administration, the weight-loaded swimming test was carried out on the mice to evaluate the antifatigue effect of TMC. In comparison with the effect of ordinary cookies, the intake of TMC significantly prolonged the exhaustive swimming time of mice and increased the level of muscle glycogen and liver glycogen, accompanied by the reduction of lactic acid and urea nitrogen level in serum. Additionally, TMC dramatically improved the activity of superoxide dismutase and glutathione peroxidase in serum and largely decreased the level of malondialdehyde. All in all, TMC could enforce exhaustive swimming tolerance, accelerate the decomposition of sports-related metabolites such as lactic acid and urea nitrogen, and increase the activity of the antioxidant enzyme, thereby improving sports-related energy storage and relieving fatigue. Our findings broadened the application of T. matsutake in the processing of bakery products and provided the theoretical basis and technical support for the development of antifatigue products.

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Nutraceuticals in Sports Activities and Fatigue

Cited by 15 publications

References 101 publications

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Functional Value of Amaranth as Applied to Sports Nutrition

Antifatigue effect of functional cookies fortified with mushroom powder (Tricholoma Matsutake) in mice

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