Nutratherapeutics approach against cancer: tomato‐mediated synthesised gold nanoparticles

Abstract

In this study, an eco-friendly biosynthesis of stable gold nanoparticles (T-GNPs) was carried out using different concentrations of tomato juice (nutraceuticals) as a reducing agent and tetrachloroauric acid as a metal precursor to explore their potential application in cancer therapeutics. The synthesis of T-GNPs was monitored by UV-visible absorption spectroscopy, which unveiled their formation by exhibiting the typical surface plasmon absorption maxima at 522 nm. The size of T-GNPs was found to be 10.86 ± 0.6 nm. T-GNPs were characterised by dynamic light scattering, zeta potential, transmission electron microscopy analysis and Fourier transform infrared spectroscopy. T-GNPs were further investigated for their anti-cancer activity against human lung carcinoma cell line (A 549) and human cervical cancer cell line wherein the IC 50 values were found to be 0.286 and 0.200 mM, respectively. T-GNPs inhibited the growth of cancer cells by generating ROS and inducing apoptosis. T-GNPs were found highly effective by virtue of their size, metallic property and capping molecules. Thus, this study opens up the prospects of using nutraceutical (tomato juice) as nutratherapeutic agent (T-GNPs) against critical diseases like lung cancer and cervical cancer.

Retracted: Synthesis characterization of Zn-based MOF and their application in degradation of water contaminants

“…Nanoscience is no exception to this rule (Barani et al 2020;Bilal et al 2020;Chu et al 2021;Sargazi et al 2021;Salarpour et al 2022). Nanoparticles such as nanocubes (AlYahya et al 2018), nanotube (Gao et al 2021;Jasim et al 2022a), nanocages (Salahdin et al 2022), nanofibrous (Jasni et al 2017), nanomagnetic (Akbarizadeh et al 2022a;Cao et al 2022;Jasim et al 2022b;Sadeghi et al 2022), nanorods (Isacfranklin et al 2020a(Isacfranklin et al , 2020b, chain like (Swathi et al 2020), nanoplates (Vidhya et al 2021), nanoporous (Yang et al 2019a), bimetallic (Cao et al 2021a;Ameen 2022), titanium (Ahmed et al 2020), silver (Ameen et al 2018(Ameen et al , 2019(Ameen et al , 2020a(Ameen et al , 2020b(Ameen et al , 2021aKim et al 2018;Mohanta et al 2018;Mythili et al 2018a;Valarmathi et al 2020;Rajadurai et al 2021;Almansob et al 2022a;Begum et al 2022), tin oxide (Al-Enazi et al 2021;Wang et al 2022b), gold (Iram et al 2017;Mythili et al 2018b;Rahim et al 2018;Alsamhary et al 2020), selenide (Naveenraj et al 2018), zinc oxide…”

Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform

“…Subsequently, the consideration of NPs with neurotrophic impacts has become a modern hotspot within the NDDs study field [ 126 ]. Nanotechnology’s rapid growth and wide range of uses necessitate a strategy for creating safe NPs [ 164 ]. The architecture of the surface is a key role in the physicochemical properties of metallic particles that influences their mechanism of action in organic or natural environments [ 10 ].…”

Efficacy of Gold Nanoparticles against Drug-Resistant Nosocomial Fungal Pathogens and Their Extracellular Enzymes: Resistance Profiling towards Established Antifungal Agents

“…In addition, the phytochemicals of plant extracts can stabilize the nanomaterials, leading to relatively higher stability [ 16 , 17 , 18 ]. In some cases, plant enzymes like bromelain and vegetable wastes or their extracts have been used to synthesize AuNPs [ 19 , 20 , 21 ]. Adding to these benefits, metallic nanoparticles, notably AuNPs, synthesized for applications in medicine are known to possess antifungal properties, particularly against pathogens capable of causing respiratory infections [ 22 , 23 , 24 , 25 , 26 , 27 ].…”