The waste source containing nitrogen (N) and organic phosphorus (P) into the hydropower reservoir will be transformed into pollutants NH4+, NO2-, NO3-, PO43-. Son La hydropower reservoir has an area of 225 km2 of water surface and 10,850 km2 of water supply basin for electricity generation, Son La hydroelectricity plant and dam, which is particularly important in terms of socio-economic and national conditions, room, security. Using the method of calculating emissions with appropriate coefficients, 10.323 tons of nitrogen / year and 5.454 tons of phosphorus / year were added to the lake in 2019 through the data of population, livestock, fish cages, farming. Semi-submerged agriculture, depositing air into the lake. Applying the method of calculating the self-cleaning capacity of hydropower reservoirs through the results of determining the total main pollutants in the catchment tons N/P, the concentration of main pollutants in the water input and out of the lake, the concentration catchment pollutant (mg/L), basin pollutant input (tons / day), hydraulic retention time. Thereby, the Son La hydropower reservoir self-cleaning 8,117 tons / year with pollutants of groups NH4+, NO2-, NO3-, PO43-, specifically a volume of 2,756 million m3 and 16 days to save water. 1,224 tons were cleaned, a capacity of 6,504 million m3 with 37 days to save water, the lake cleaned 2,856 tons, a capacity of 9,266 million m3, and a retention time was 52 days, the lake cleaned 4,037 tons.