Nutrional aspect of zinc availability

Cámara, F.; Amaro, Manuel

doi:10.1080/0963748031000084098

Cited by 53 publications

(33 citation statements)

References 69 publications

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“…The association of the Zn with the yeast proteins and carbohydrate slowed the initial uptake rate within the first hour but also apparently reduced the excretion rate in the feces, but not the urine. Our findings with Zn yeast are consistent with previous studies that demonstrated animal proteins could improve Zn absorption [13]. Physiologically, this makes sense because the main dietary source of Zn is proteins [13].…”

Section: Resultssupporting

confidence: 93%

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Clinical Evaluation of the Bioavailability of Zinc-enriched Yeast and Zinc Gluconate in Healthy Volunteers

Tompkins¹,

Renard²,

Kiuchi³

2007

Biol Trace Elem Res

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Zinc (Zn)-enriched yeast and gluconate are considered two of the more biologically available supplements. However, there have been few reports comparing the bioavailability of these supplements. The objective of this study was to demonstrate whether Zn was absorbed better by healthy male volunteers when given supplements where the mineral is found organically bound in yeast or as a salt gluconate form. The trial used a randomized, two-way crossover design. Urine, blood, and fecal samples were collected and analyzed over a 48-h period after a single dose of supplement. The net Zn balance and the relative bioavailability were calculated. No differences were observed in urine excretion of the two supplements. Zinc gluconate gave higher Zn concentrations in the blood in the first 6 h but also showed greater losses in the feces. Zinc yeast also increased in blood with time but showed significantly less loss in the feces. Thus, the net Zn balance after 48 h for Zn yeast was 9.46 but for Zn gluconate it was -2.00, indicating that Zn gluconate supplementation contributed to a net loss of Zn. It was concluded that organic Zn yeast supplements are more biologically available than Zn gluconate salts.

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Section: Resultssupporting

confidence: 93%

“…Our findings with Zn yeast are consistent with previous studies that demonstrated animal proteins could improve Zn absorption [13]. Physiologically, this makes sense because the main dietary source of Zn is proteins [13].…”

Section: Resultssupporting

confidence: 93%

Clinical Evaluation of the Bioavailability of Zinc-enriched Yeast and Zinc Gluconate in Healthy Volunteers

Tompkins¹,

Renard²,

Kiuchi³

2007

Biol Trace Elem Res

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“…Both ZnY and ZnSO 4 were slowly eliminated in vivo with respective t 1/2, λz values of 7.68 and 7.93 h. During ZnY fermentation in the presence of Zn chloride or ZnSO 4 , a specific strain of yeast produced specific zinc compounds conjugated with proteins, peptides, and amino acids, which helped improve bioavailability of ZnY compared to inorganic Zn via enhanced intestinal absorption. Our findings with ZnY are consistent with previous studies in which animal proteins could improve Zn absorption [6, 10], which could physiologically illustrate protein as the major dietary source of Zn.…”

Section: Resultssupporting

confidence: 92%

Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Zhang

Zhang²,

Ning³

et al. 2014

The Scientific World Journal

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Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.

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“…Moreover, zinc stabilizes the structures of proteins and nucleic acids and is also involved in immune phenomena (Salgueiro et al 2000;Camara and Amaro 2003).…”

Section: Resultsmentioning

confidence: 99%

Survey of 13 trace elements of toxic and nutritional significance in rice from Brazil and exposure assessment

Batista

Souza

Silva

et al. 2010

Food Additives and Contaminants: Part B

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Twenty-seven rice samples from Brazil, four parboiled brown, seventeen white and six parboiled white were analysed by ICP-MS for trace element determination. Concentrations of arsenic varied from 58.8 to 216.9 ng g(-1), for cadmium from 6.0 to 20.2 ng g(-1), for antimony from 0.12 to 1.28 ng g(-1), and for uranium from 0.025 to 1.28 ng g(-1). The estimated daily intake through rice consumption was 9.5 µg for As, 2.4 µg for Cd, 0.029 µg for Sb, 0.013 µg for U, 3.1 µg for Co, 0.2 µg for Cu, 85.6 mg for Mg, 1.9 mg for Mn, 333 mg for P, 3.0 µg for Se, 1.6 mg for Zn, 0.9 mg for Rb, and 0.3 µg for V. Found values represent a considerable percentage of the dietary reference intakes and provisional tolerable daily intake for essential and toxic elements, respectively.

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Nutrional aspect of zinc availability

Cited by 53 publications

References 69 publications

Clinical Evaluation of the Bioavailability of Zinc-enriched Yeast and Zinc Gluconate in Healthy Volunteers

Clinical Evaluation of the Bioavailability of Zinc-enriched Yeast and Zinc Gluconate in Healthy Volunteers

Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

Survey of 13 trace elements of toxic and nutritional significance in rice from Brazil and exposure assessment

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