Nutrition and degeneration of articular cartilage

Wang, Yu-ze; Wei, Lei; Zeng, Lei; He, Dalin; Wei, Xiaochun

doi:10.1007/s00167-012-1977-7

Cited by 64 publications

(36 citation statements)

References 32 publications

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“…Recently, several studies demonstrated that nutrient supply of natural articular cartilage mainly comes from synovial fluid [26]. Our study shows that, IV bioreactor fluid component analysis showed that protein, glucose, and HA were close to synovial fluid than serum ( Table 2).…”

Section: Discussionsupporting

confidence: 57%

In vivo bioreactor using cellulose membrane benefit engineering cartilage by improving the chondrogenesis and modulating the immune response

Park

Choi

et al. 2019

Preprint

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To regenerate tissue engineered cartilage as a source for the restoration of cartilage defects, we used a human fetal cartilage progenitor cell (hFCPC) pellet for improve the chondrogenesis and modulation the immune response with a In vivo (IV) bioreactor system, that was buried subcutaneously in the host and then implanted into a cartilage defect. In vivo bioreactor (IVB) was composed of silicone tube and cellulose nanopore-size membrane. FCPC pellets were first cultured in vitro for 3 days, and then cultured in vitro, subcutaneous and IV bioreactor for 3 weeks. First evaluated the IV bioreactor fluid appearance, component and liquidity, and then evaluate chondrogenesis and immunogenicity of the pellets using gross observation, cell viability, histology, biochemical analysis, RT-PCR, and Western Blot, finally evaluates the cartilage repair and synovial inflammation using histology. The fluid color and transparency of IV bioreactor were similar to synovial fluid (SF) and the component was also close to SF compared to the serum. IV bioreactor system not only promotes the synthesis of cartilage matrix and maintains cartilage phenotype, but also delays the occurrence of calcification compared with subcutaneous. A IV bioreactor, which has been predominantly adopted to study cell differentiation, was effective in preventing host immune rejection.

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Section: Discussionsupporting

confidence: 57%

In vivo bioreactor using cellulose membrane benefit engineering cartilage by improving the chondrogenesis and modulating the immune response

Park

Choi

et al. 2019

Preprint

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“…In fact, Wang et al [20] found that synovial fluid, but not SB, provides enough nutrients to maintain cartilage structure and function in mature rabbits.…”

Section: Transporting Lipids Through the Cartilagementioning

confidence: 99%

Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage

Villalvilla

Gómez

Largo

et al. 2013

IJMS

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Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.

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“…Our results proved that there was a decline in the diffusion of Visipaque with aging. Thereby, the lack of enough metabolite transport from the cartilage surface might result in blood vessel invasion and subchondral bone advancement 39 .…”

Section: Discussionmentioning

confidence: 99%