Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Choi, In Young; Lee, Changhan; Longo, Valter D.

doi:10.1016/j.mce.2017.01.042

Cited by 110 publications

(98 citation statements)

References 117 publications

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“…Caloric restriction improves chronic inflammatory and autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis (Choi et al, 2017;Piccio et al, 2008). Intriguingly, gene modules associated with "inflammation of joint" and "rheumatoid arthritis" were 25 reduced in monocytes isolated from fasting mice ( Figure S5A and S5B).…”

Section: Emergency Mobilization During Acute Inflammationmentioning

confidence: 97%

“…Accordingly, the recent diet westernization of developing countries has been associated with an increased prevalence of inflammatory or autoimmune disorders (Manzel et al, 2014). In contrast, reduced caloric intake is associated with improved outcomes for metabolic, autoimmune and inflammatory diseases, including NAFLD (Kani et al, 2017), T2DM , CVD (Wei et al,10 2017), multiple sclerosis (Choi et al, 2016;Jahromi et al, 2014), rheumatoid arthritis (Choi et al, 2017;Kjeldsen-Kragh et al, 1991), asthma (Johnson et al, 2007), psoriasis (Jensen et al, 2016), colitis (Shibolet et al, 2002), and sepsis (Starr et al, 2016;Wannemacher et al, 1979) and has been shown to prolong the lifespan of rodents, monkeys, and humans (Fontana et al, 2010;Picca et al, 2017). However, the molecular mechanisms by which caloric restriction 15 modulates systemic inflammation remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Dietary intake regulates the circulating inflammatory monocyte pool

Jordan

Tung

Casanova-Acebes

et al. 2019

Preprint

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Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. 5Regulation of peripheral monocyte numbers was dependent on dietary glucose and protein levels. Specifically, we found that activation of the low-energy sensor 5'-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPARα) reduced monocyte mobilization from the bone marrow. Importantly, while caloric restriction improves chronic inflammatory 10 diseases, fasting did not compromise monocyte emergency mobilization during acute infectious inflammation and tissue repair. These results reveal that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory disease outcome. 15

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Section: Emergency Mobilization During Acute Inflammationmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Dietary intake regulates the circulating inflammatory monocyte pool

Jordan

Tung

Casanova-Acebes

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…Periodic fasting (PF) and fasting-mimicking diets (FMDs) have been effective in increasing healthy lifespan or as therapies in mouse models for a variety of diseases (Choi et al, 2017; Lee and Longo, 2016; Brandhorst et al, 2015). FMDs can reduce cancer incidence and aging-associated immunosuppression/immunosenescence, a process aided by hematopoietic stem-cell-based regeneration (Brandhorst et al, 2015; Cheng et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

et al. 2019

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SUMMARY Dietary interventions are potentially effective therapies for inflammatory bowel diseases (IBDs). We tested the effect of 4-day fasting-mimicking diet (FMD) cycles on a chronic dextran sodium sulfate (DSS)-induced murine model resulting in symptoms and pathology associated with IBD. These FMD cycles reduced intestinal inflammation, increased stem cell number, stimulated protective gut microbiota, and reversed intestinal pathology caused by DSS, whereas water-only fasting increased regenerative and reduced inflammatory markers without reversing pathology. Transplants of Lactobacillus or fecal microbiota from DSS- and FMD-treated mice reversed DSS-induced colon shortening, reduced inflammation, and increased colonic stem cells. In a clinical trial, three FMD cycles reduced markers associated with systemic inflammation. The effect of FMD cycles on microbiota composition, immune cell profile, intestinal stem cell levels and the reversal of pathology associated with IBD in mice, and the anti-inflammatory effects demonstrated in a clinical trial show promise for FMD cycles to ameliorate IBD-associated inflammation in humans.

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“…Finally, although the strategy of alleviating or actually reverting autoimmune disorders in humans by fasting mimicking diets is among the most promising new potential therapeutic approach for these pathologies , caution is still necessary, especially regarding the feasibility of food deprivation in our species.…”

Section: The Metabolic Aspects Of Immune Functionmentioning

confidence: 99%

Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles

et al. 2017

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Edited by Wilfried EllmeierImmunometabolism focuses on the mechanisms regulating the impact of metabolism on lymphocyte activity and autoimmunity outbreak. The adipose tissue is long known to release adipokines, either pro-or anti-inflammatory factors bridging nutrition and immune function. More recently, adipocytes were discovered to also release extracellular vesicles (EVs) containing a plethora of biological molecules, including metabolites and microRNAs, which can regulate cell function/metabolism in distant tissues, suggesting that immune regulatory function by the adipose tissue may be far more complex than originally thought. Moreover, EVs were also identified as important mediators of immune cell-to-cell communication, adding a further microenvironmental mechanism of plasticity to fine-tune specific lymphocyte responses. This Review will first focus on the known mechanisms by which metabolism impacts immune function, presenting a systemic (nutrition and long-ranged adipokines) and a cellular point of view (metabolic pathway derangement in autoimmunity). It will then discuss the new discoveries concerning how EVs may act as nanometric vehicles integrating immune/metabolic responses at the level of the extracellular environment and affecting pathological processes.Keywords: adipose tissue; autoimmunity; extracellular microRNAs; extracellular vesicles; lymphocytes Immunometabolism is the research field that links immunology and metabolism, originally regarded as distinct disciplines [1]. Growing interest in the field has being fostered by recent understanding that the metabolic state of an organism has an impact on lymphocyte physiology and activity. CD4

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Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Cited by 110 publications

References 117 publications

Dietary intake regulates the circulating inflammatory monocyte pool

Dietary intake regulates the circulating inflammatory monocyte pool

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles

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