Nutrition and kidney in preterm infant

Curtis, Mario De; Rigo, Jacques

doi:10.3109/14767058.2012.663167

Cited by 16 publications

(17 citation statements)

References 31 publications

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“…The correlation between PMA and urinary metabolite profiles has been reported previously [17,31,32], and may reflect the degree of organ development and metabolic maturity. Between the first and the third week of life the glucogenic amino acids glycine, threonine, hydroxyproline and tyrosine increased along with metabolites of the tricarboxylic acid cycle like 2-oxoglutarate, citrate, fumarate and succinate.…”

Section: Discussionsupporting

confidence: 73%

Urinary Metabolite Profiles in Premature Infants Show Early Postnatal Metabolic Adaptation and Maturation

et al. 2014

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Objectives: Early nutrition influences metabolic programming and long-term health. We explored the urinary metabolite profiles of 48 premature infants (birth weight < 1500 g) randomized to an enhanced or a standard diet during neonatal hospitalization. Methods: Metabolomics using nuclear magnetic resonance spectroscopy (NMR) was conducted on urine samples obtained during the first week of life and thereafter fortnightly. Results: The intervention group received significantly higher amounts of energy, protein, lipids, vitamin A, arachidonic acid and docosahexaenoic acid as compared to the control group. Enhanced nutrition did not appear to affect the urine profiles to an extent exceeding individual variation. However, in all infants the glucogenic amino acids glycine, threonine, hydroxyproline and tyrosine increased substantially during the early postnatal period, along with metabolites of the tricarboxylic acid cycle (succinate, oxoglutarate, fumarate and citrate). The metabolite changes correlated with postmenstrual age. Moreover, we observed elevated threonine and glycine levels in first-week urine samples of the small for gestational age (SGA; birth weight < 10th percentile for gestational age) as compared to the appropriate for gestational age infants. Conclusion: This first nutri-metabolomics study in premature infants demonstrates that the physiological adaptation during the fetal-postnatal transition as well as maturation influences metabolism during the breastfeeding period. Elevated glycine and threonine levels were found in the first week urine samples of the SGA infants and emerged as potential biomarkers of an altered metabolic phenotype.

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Section: Discussionsupporting

confidence: 73%

Urinary Metabolite Profiles in Premature Infants Show Early Postnatal Metabolic Adaptation and Maturation

et al. 2014

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“…The nephrons are the functional units of the kidney, hence, the number of nephrons formed within the kidney at completion of nephrogenesis directly influences lifetime renal functional capacity and reserve [29]; it is essential, therefore, that adequate nephrogenesis is achieved at the very beginning of life. Autopsy studies over the past two decades have demonstrated that there is a wide range in nephron number in the human kidney [30–38]; overall, nephron number has been shown to range from approximately 200,000 to over 2 million per kidney [39].…”

Section: Iugr and Preterm Birth Adversely Impact On Nephrogenesismentioning

confidence: 99%

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

Zohdi

Sutherland

Lim

et al. 2012

International Journal of Nephrology

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Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life. Importantly, nephrons are only formed early in life; during normal gestation, nephrogenesis is complete by about 32–36 weeks, with no new nephrons formed after this time during the lifetime of the individual. Hence, given that a loss of a critical number of nephrons is the hallmark of renal disease, an increased severity and acceleration of renal disease is likely when the number of nephrons is already reduced prior to disease onset. Low birth weight can result from intrauterine growth restriction (IUGR) or preterm birth; a high proportion of babies born prematurely also exhibit IUGR. In this paper, we describe how IUGR and preterm birth adversely impact on nephrogenesis and how a subsequent reduced nephron endowment at the beginning of life may lead to long-term risk of renal disease, but not necessarily hypertension.

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“…A normal range of Ca/P will lead to optimal bone mineralization and bone formation 17,22,44) . The Ca/P of native bone hydroxyapatite (HA) is 1.67 in human, so most bone related bioactive materials aims at this criteria.…”

Section: Discussionmentioning

confidence: 99%

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Liu

Wang

Dong

et al. 2019

J. Hard Tissue Biology.

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The study was to observe dental implant osseointegration at early stage and analysis the influencement of the ratio of calcium and phosphorus variation on osseointegration in hyperlipidemic rats. Wistar rats were randomly divided into control group with normal diet and experimental group with high fat diet. 8 weeks later, serum lipid levels was detected and titanium implants were placed into bilateral femurs. At day1, 3, 5 after implant, rats were sacrificed and 5 mm bone with implants was obtained. hard tissue slices and methylene blue-acid fuchsin staining were performed to observe the interface of bone-implant. And energy disperse X-ray spectrometer (EDS) was used to measure the percentage of oxygen and the ratio of calcium and phosphorus. All rats in experimental group were successfully induced into hyperlipidemic status. Histological results revealed less osteoblasts and trabecular bone, but more osteoclasts and trabecular space in experimental group than those in control group. Higher content of oxygen and lower ration of calcium and phosphorus were also observed in experimental group than those in control group (P<0.05). Hyperlipidemia could hinder implant osseointegration at early stage after implantation. This inhibition might be closely related to higher content of oxygen and lower ratio of calcium and phosphorus.

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Nutrition and kidney in preterm infant

Cited by 16 publications

References 31 publications

Urinary Metabolite Profiles in Premature Infants Show Early Postnatal Metabolic Adaptation and Maturation

Urinary Metabolite Profiles in Premature Infants Show Early Postnatal Metabolic Adaptation and Maturation

Low Birth Weight due to Intrauterine Growth Restriction and/or Preterm Birth: Effects on Nephron Number and Long-Term Renal Health

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

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