Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part II

Abstract

Vascular biology, endothelial and vascular smooth muscle, and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease, and target organ damage. Nutrient‐gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control, and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation, and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the select use of single and component nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension based on scientifically controlled studies, which complement optimal nutrition, coupled with other lifestyle modifications.

Treatment of Hypertension with Nutrition and Nutraceutical Supplements: Part 2

“…20 A vitamin D level of 60 ng/mL is recommended for optimal BP reduction and cardiovascular disease (CVD) risk reduction. [1][2][3][4] Vitamin B6 (Pyridoxine) Low serum vitamin B6 (pyridoxine) levels are associated with hypertension in humans. [1][2][3][4][24][25][26][27][28] High-dose vitamin B6 significantly lowered BP by 14/10 mmHg (P < 0.005) and serum catecholamine levels (P < 0.05) in a placebo-controlled study of 20 hypertensive subjects who were administered vitamin B6 at 5 mg/kg/day for four weeks.…”

“…[1][2][3][4] Vitamin B6 (Pyridoxine) Low serum vitamin B6 (pyridoxine) levels are associated with hypertension in humans. [1][2][3][4][24][25][26][27][28] High-dose vitamin B6 significantly lowered BP by 14/10 mmHg (P < 0.005) and serum catecholamine levels (P < 0.05) in a placebo-controlled study of 20 hypertensive subjects who were administered vitamin B6 at 5 mg/kg/day for four weeks. 25 In a placebo-controlled trial over 12 weeks, in which participants were given 800 mg lipoic acid and 80 mg pyridoxine, results showed that serum lipoic acid and pyridoxine, urinary albumin, serum malondialdehyde, and SBP decreased significantly in the supplement group compared to the placebo group (P < 0.05).…”

“…28 Vitamin B6 thus has similar action to central alpha agonists, diuretics, and calcium channel blockers (CCB). [1][2][3][4] The recommended dose is 200 mg/day orally at which no adverse effects have been reported related to neuropathy. [1][2][3][4] Flavonoids: Resveratrol and Pomegranate Flavonoids (flavonols, flavones, and isoflavones) are potent free radical scavengers that prevent atherosclerosis, promote vascular relaxation, and have antihypertensive properties.…”

“…[1][2][3][4] The recommended dose is 200 mg/day orally at which no adverse effects have been reported related to neuropathy. [1][2][3][4] Flavonoids: Resveratrol and Pomegranate Flavonoids (flavonols, flavones, and isoflavones) are potent free radical scavengers that prevent atherosclerosis, promote vascular relaxation, and have antihypertensive properties. [29][30][31][32][33][34][35][36][37][38][39] Resveratrol administration to humans reduces augmentation index, improves arterial compliance, and lowers central arterial pressure when administered as 250 mL of either regular or dealcoholized red wine.…”

Bedeutung der Elektrolyte und Vitamine bei Hypertonie

“…Störungen im Elektrolythaushalt sind bei Patienten mit Hypertonie gut dokumentiert [2][3][4]. Antihypertensive Medikamente selbst spielen bei der Entstehung von Mineralstoffmängeln eine Rolle [5].…”