Nutrition and the Role of Reducing Agents in the Formation of Streptolysin O by a Group a Hemolytic Streptococcus

Slade, Hutton D.; Knox, Grace A.

doi:10.1128/jb.60.3.301-310.1950

Cited by 32 publications

(9 citation statements)

References 16 publications

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“…The basal medium used has been reported previously (Slade and Knox, 1950). This medium has been modified in the present experiments by the addition of 5 mg sodium ethyl oxalacetate, 5 mg sodium fumarate, 1 mg ascorbic acid, and 0.02 ,g vitamin B122 per 10 ml tube.…”

Section: Methodsmentioning

confidence: 99%

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The Amino Acid Nutrition of Group a Hemolytic Streptococci, With Reference to the Effect of Glutathione on the Cystine Requirement

1951

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Section: Methodsmentioning

confidence: 99%

“…A culture medium chemically-defined except for a pancreatic digest of casein was shown to support rapid growth of a group A hemolytic streptococcus (Slade and Knox, 1950). In order to have available a completely dialyzable culture medium for studies on the formation of streptolysin 0, it was necessary to replace the casein digest with a mixture of amino acids.…”

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The Amino Acid Nutrition of Group a Hemolytic Streptococci, With Reference to the Effect of Glutathione on the Cystine Requirement

1951

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“…Parallel tests were made on 47 strains for leukotoxieity and for streptolysin 0 production by the method of Slade and Knox (10).…”

Section: Relation Of Streptococcal Leukotoxi~ity To Known Streptococcmentioning

confidence: 99%

The Leukotoxic Action of Streptococci

Wilson

1957

The Journal of Experimental Medicine

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P r~s 33 ~o 41(Received for publication, January 7, 1957) This is the third study in a series on the interactions between streptococci and host cells. Previous reports have concerned the egestion of streptococci by phagocytic cells (1), and the failure of streptococci to lose their capacity of resisting phagocytosis after being killed with gentle heat or ultraviolet radiation (2). The present work is concerned with one type of outcome following phagocytosis; namely, the destruction of the phagocytizing leukocytes which occurs when certain strains of streptococci are ingested. This injury will be called here "leukotoxic action," and the pertinent attribute of injurious streptococci will be called "leukotoxicity." It was described by Levaditi in 1918 (3), but has received no attention since that time as far as we have been able to discover.The leukotoxic effect is seen only after intact cocci have been phagocytized. It must not be confused with the action of streptococcal leukocidin, a soluble substance elaborated into the medium by growing cocci, which destroys leukocytes even when all coccal cells have been removed by filtration. Todd has presented impressive evidence indicating that leukocidin and streptolysin O are identical (4).In the present report consideration will be given to the biological characteristics of leukotoxicity, to its distribution among streptococci, its relation to other known streptococcal products, its relationship to virulence and its possible significance in streptococcal disease.

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“…That streptolysin 0 and nicotinamide adenine dinucleotidase, in their active forms, are separate substances was well substantiated immunologically (Carlson et al, 1957;Pace and Pappenheimer, 1959;Halbert, 1958;Halbert and Auerbach, 1956;Bernard and Stollerman, 1959). However, they do have several properties in common, PENTZ, KOT, AND FERRETTI namely, their instability; their ability to be influenced by reducing compounds, such as cysteine and glutathione (Slade and Knox, 1950;Ayoub and Wannamaker, 1963); and, as will be shown here, some striking differences as well as some similarities in their amino acid content.…”

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confidence: 67%

Some Characteristics of Streptococcal Nicotinamide Adenine Dinucleotidase and Streptolysin O

1964

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Nutrition and the Role of Reducing Agents in the Formation of Streptolysin O by a Group a Hemolytic Streptococcus

Cited by 32 publications

References 16 publications

The Amino Acid Nutrition of Group a Hemolytic Streptococci, With Reference to the Effect of Glutathione on the Cystine Requirement

The Amino Acid Nutrition of Group a Hemolytic Streptococci, With Reference to the Effect of Glutathione on the Cystine Requirement

The Leukotoxic Action of Streptococci

Some Characteristics of Streptococcal Nicotinamide Adenine Dinucleotidase and Streptolysin O

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