Nutrition as Treatment Modality in Heart Failure

Ishikawa, Yuta; Sattler, Elisabeth Lilian Pia

doi:10.1007/s11883-021-00908-5

Cited by 8 publications

(8 citation statements)

References 91 publications

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“…It was found that patients with lower estimated protein intake have a higher prevalence of ID (particularly absolute ID [ 71 ]), indicating poor nutritional status as a potential cause of ID in HF [ 51 ]. Studies show that approximately 35% to 78% of HF patients suffer from malnutrition, which has also been independently associated with adverse outcomes [ 72 , 73 , 74 , 75 ]. The aetiology of malnutrition is complex and thought to be multifactorial where fatigue, dyspnoea, swallowing disturbances, nausea, anxiety, food monotony, reduced appetite and early satiety could play a role [ 76 , 77 , 78 ].…”

Section: Causes Of Iron Deficiency In Heart Failurementioning

confidence: 99%

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Alnuwaysir

Hoes

Veldhuisen

et al. 2021

JCM

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Iron is an essential micronutrient for a myriad of physiological processes in the body beyond erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF), with a prevalence reaching up to 59% even in non-anaemic patients. ID impairs exercise capacity, reduces the quality of life, increases hospitalisation rate and mortality risk regardless of anaemia. Intravenously correcting ID has emerged as a promising treatment in HF as it has been shown to alleviate symptoms, improve quality of life and exercise capacity and reduce hospitalisations. However, the pathophysiology of ID in HF remains poorly characterised. Recognition of ID in HF triggered more research with the aim to explain how correcting ID improves HF status as well as the underlying causes of ID in the first place. In the past few years, significant progress has been made in understanding iron homeostasis by characterising the role of the iron-regulating hormone hepcidin, the effects of ID on skeletal and cardiac myocytes, kidneys and the immune system. In this review, we summarise the current knowledge and recent advances in the pathophysiology of ID in heart failure, the deleterious systemic and cellular consequences of ID.

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Section: Causes Of Iron Deficiency In Heart Failurementioning

confidence: 99%

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Alnuwaysir

Hoes

Veldhuisen

et al. 2021

JCM

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“…Particularly, fat-soluble CoQ10 is not efficiently absorbed. Therefore, micronutrient supplementation should preferably occur in combination with offering balanced meals, or individualized dietary guidance or supplementation to patients with HF [188][189][190].…”

Section: Multi-micronutrient Interventionsmentioning

confidence: 99%

Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?

et al. 2022

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Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish the disease burden. New strategies to treat or prevent heart failure are urgently needed. Over the past decades, a clear relationship has been established between poor cardiac performance and metabolic perturbations, including deficits in substrate uptake and utilization, reduction in mitochondrial oxidative phosphorylation and excessive reactive oxygen species production. Together, these perturbations result in progressive depletion of cardiac adenosine triphosphate (ATP) and cardiac energy deprivation. Increasing the delivery of energy substrates (e.g., fatty acids, glucose, ketones) to the mitochondria will be worthless if the mitochondria are unable to turn these energy substrates into fuel. Micronutrients (including coenzyme Q10, zinc, copper, selenium and iron) are required to efficiently convert macronutrients to ATP. However, up to 50% of patients with heart failure are deficient in one or more micronutrients in cross‐sectional studies. Micronutrient deficiency has a high impact on mitochondrial energy production and should be considered an additional factor in the heart failure equation, moving our view of the failing myocardium away from an “an engine out of fuel” to “a defective engine on a path to self‐destruction.” This summary of evidence suggests that supplementation with micronutrients—preferably as a package rather than singly—might be a potential therapeutic strategy in the treatment of heart failure patients.

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“…Хотя традиционное внимание при разработке вопросов, связанных с диетотерапией пациентов ХСН, было сосредоточено на исследовании эффектов отдельных питательных веществ, в настоящее время все более очевидным становится необходимость комплексной оценки моделей питания, включающих сложные взаимосвязи между различными компонентами рациона питания [23]. DASH рацион (Dietary Approaches to Stop Hypertension -диетические подходы к борьбе с гипертонией) и средиземноморская диета (MedDiet) являются наиболее часто изучаемыми диетическими паттернами в отношении как профилактики развития ХСН, так и улучшения исходов у пациентов с клинически выраженными ее проявлениями [24,25].…”

Section: комплексные диеты в лечении и профилактике хснunclassified

“…Кроме того, приверженность диете DASH была связана со значительно более низким риском смерти от ХСН [37]. Таким образом, использование диеты DASH может быть перспективным направлением профилактики и лечения ХСН [24].…”

Section: комплексные диеты в лечении и профилактике хснunclassified

“…В меньшей степени у пациентов с ХСН оценивалась польза от применения флавоноидной фракции боярышника, левокарнитина, тиамина, витаминов Д, Е, С, магния, и практически отсутствуют данные относительно витаминов А, В6, В12, фолиевой кислоты, селена, про-, пребиотиков и др. [7,24,[61][62][63][64][65][66].…”

Section: ω-3 полиненасыщенные жирные кислотыunclassified

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The Modern Aspects of Nutrition during Chronic Heart Failure

Саликова

Гриневич

Власов

2022

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Nutrition occupies one of the important places in the programs of prevention and non-drug therapy of CHF and associated diseases. At the same time, the validity of dietary recommendations to patients regarding salt intake, dietary habits and the use of individual nutraceuticals is questionable. The purpose of this review is to present up-to-date data of clinical and experimental studies concerning sodium restriction, the use of various diets, nutraceuticals, and means for correcting intestinal dysbiosis in CHF. Materials and methods: the articles are searched in the databases eLibraryRU and Medline by key terms and their combinations: “heart failure”, “diet”, “sodium restriction”, “nutraceuticals”, “nutrition”, “cardiac cachexia”, “nutritional support”, “salt”, “dietary supplement”, “probiotic”, “prebiotic”, “enteral nutrition” in Russian and English. We select articles containing the results of clinical and experimental studies published from 1997 to 2021. The research data indicate that the pathogenesis of anorexia, malnutrition and “metabolic remodeling” of the myocardium in CHF is based on complex mechanisms determined by stagnant phenomena in the liver, impaired permeability of the edematous intestinal wall, dysbiosis and chronic systemic infl ammation. The recommendations on the consumption of sodium from 2 to 2.5 g/day and table salt from 5 to 6 g/day in patients with CHF are justified. Limitation of fluid intake is relevant only for decompensation of CHF. The use of the Mediterranean and antihypertensive (DASH) diets is recognized by most authors as a promising direction for the prevention and treatment of CHF. The enrichment of the diet of patients with CHF with ω-3 polyunsaturated fatty acids, coenzyme Q10, dietary fibers, polyphenols and saponins is justified. The benefits of enteral nutrition and the complex use of nutraceuticals in order to slow the progression of weight loss, reduce the severity of neurohormonal and pro-inflammatory shifts are shown. Promising trends of research are the creation of personalized diets taking into account the peculiarities of the course of CHF, the nutritional status, the composition of the intestinal microbiota and its metabolites.

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Nutrition as Treatment Modality in Heart Failure

Cited by 8 publications

References 91 publications

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?

The Modern Aspects of Nutrition during Chronic Heart Failure

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