Nutrition of Broodmares

Robles, Morgane; Hammer, C.J.; Staniar, Burt; Chavatte‐Palmer, Pascale

doi:10.1016/j.cveq.2021.01.001

Cited by 6 publications

(8 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No effect of maternal obesity was observed on foal birthweight or placental morphometry. These results are not surprising, as only extreme pathologies (such as extreme undernutrition or bacterial infection) have been shown to affect feto-placental measurements at birth in horses [ 2 , 43 ].…”

Section: Discussionmentioning

confidence: 98%

“…Alterations in the early environment, from conception until the end of puberty, have been demonstrated to affect the development of the individual and his health in adulthood in both humans and animal models. The developmental origins of health and diseases (DOHaD) can also be applied to the horse [ 1 , 2 , 3 , 4 ], as embryo transfer [ 5 , 6 , 7 , 8 , 9 ], maternal overnutrition [ 10 , 11 , 12 , 13 ], undernutrition [ 14 , 15 , 16 ], and obesity [ 17 ] have been shown to affect the development of foals until at least 2 years of age.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Robles,

Rousseau-Ralliard,

Dubois

et al. 2023

Veterinary Sciences

Self Cite

View full text Add to dashboard Cite

In horses, the prevalence of obesity is high and associated with serious metabolic pathologies. Being a broodmare has been identified as a risk factor for obesity. In other species, maternal obesity is known to affect the development of the offspring. This article is a follow-up study of previous work showing that Obese mares (O, n = 10, body condition score > 4.25 at insemination) were more insulin resistant and presented increased systemic inflammation during pregnancy compared to Normal mares (N, n = 14, body condition score < 4 at insemination). Foals born to O mares were more insulin-resistant, presented increased systemic inflammation, and were more affected by osteoarticular lesions. The objective of the present study was to investigate the effect of maternal obesity on placental structure and function, as well as the fatty acid profile in the plasma of mares and foals, colostrum, and milk until 90 days of lactation, which, to our knowledge, has been poorly studied in the horse. Mares from both groups were fed the same diet during pregnancy and lactation. During lactation, mares were housed in pasture. A strong heat wave, followed by a drought, occurred during their 2nd and 3rd months of lactation (summer of 2016 in the Limousin region, France). In the present article, term placental morphometry, structure (stereology), and gene expression (RT-qPCR, genes involved in nutrient transport, growth, and development, as well as vascularization) were studied. Plasma of mares and their foals, as well as colostrum and milk, were sampled at birth, 30 days, and 90 days of lactation. The fatty acid composition of these samples was measured using gas chromatography. No differences between the N and O groups were observed for term placental morphometry, structure, or gene expression. No difference in plasma fatty acid composition was observed between groups in mares. The plasma fatty acid profile of O foals was more pro-inflammatory and indicated an altered placental lipid metabolism between birth and 90 days of age. These results are in line with the increased systemic inflammation and altered glucose metabolism observed until 18 months of age in this group. The colostrum fatty acid profile of O mares was more pro-inflammatory and indicated an increased transfer and/or desaturation of long-chain fatty acids. Moreover, O foals received a colostrum poorer in medium-chain saturated fatty acid, a source of immediate energy for the newborn that can also play a role in immunity and gut microbiota development. Differences in milk fatty acid composition indicated a decreased ability to adapt to heat stress in O mares, which could have further affected the metabolic development of their foals. In conclusion, maternal obesity affected the fatty acid composition of milk, thus also influencing the foal’s plasma fatty acid composition and likely participating in the developmental programming observed in growing foals.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Robles,

Rousseau-Ralliard,

Dubois

et al. 2023

Veterinary Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nutritional support is as a critical part of supporting a pregnant mare and addressing the primary disease process (Dolente, 2004). Nutritional requirements of the pregnant broodmare increase dramatically during late gestation, where mares require up to 1.3–1.5 times the adult maintenance requirements for energy and protein (National Research Council, 2007; Robles et al., 2021). Additionally, in a study by Silver and colleagues, experimental fasting in the pregnant mare was shown to increase the concentration of a prostaglandin metabolite along with possible premature delivery (Silver, 1982).…”

Section: Nutritionmentioning

confidence: 99%

Ancillary treatment to support pregnancy in cases of medical disease

Beachler

2022

Equine Veterinary Education

View full text Add to dashboard Cite

“…148 Data in the horse are relatively scarce but have highlighted the role of the maternal environment on postnatal body conformation, sexual maturity, immune response, metabolism, osteoarticular state, and cardiovascular function of the foal. 149,150 A specific area of interest has been the evaluation of the effect of maternal overnutrition and obesity on foal outcomes. Overfeeding of mares during pregnancy to induce late-gestation obesity resulted in foals with delayed testicular maturation and insulin resistance up to 2 years of age.…”

Section: Developmental Origin Of Metabolic Disease and Placental Func...mentioning

confidence: 99%

A one-health approach to identifying and mitigating the impact of endocrine disorders on human and equine athletes

Manfredi

Jacob

Boger

et al. 2022

ajvr

View full text Add to dashboard Cite

Endocrinopathies affect multiple species in ever-increasing percentages of their populations, creating an opportunity to apply one-health approaches to determining creative preventative measures and therapies in athletes. Obesity and alterations in insulin and glucose dynamics are medical concerns that play a role in whole-body health and homeostasis in both horses and humans. The role and impact of endocrine disorders on the musculoskeletal, cardiovascular, and reproductive systems are of particular interest to the athlete. Elucidation of both physiologic and pathophysiologic mechanisms involved in disease processes, starting in utero, is important for development of prevention and treatment strategies for the health and well-being of all species. This review focuses on the unrecognized effects of endocrine disorders associated with the origins of metabolic disease; inflammation at the intersection of endocrine disease and related diseases in the musculoskeletal, cardiovascular, and reproductive systems; novel interventions; and diagnostics that are informed via multiomic and one-health approaches. Readers interested in further details on specific equine performance conditions associated with endocrine disease are invited to read the companion Currents in One Health by Manfredi et al, JAVMA, February 2023.

show abstract

Nutrition of Broodmares

Cited by 6 publications

References 111 publications

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Ancillary treatment to support pregnancy in cases of medical disease

A one-health approach to identifying and mitigating the impact of endocrine disorders on human and equine athletes

Contact Info

Product

Resources

About