Nutrition Patterns and Their Gender Differences among Rheumatoid Arthritis Patients: A Descriptive Study

Heidt, Christina; Kämmerer, Ulrike; Marquardt, Thorsten; Reuß‐Borst, Monika

doi:10.3390/nu15010095

Cited by 5 publications

(3 citation statements)

References 75 publications

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“…A 3-day estimated dietary record was collected from 61/61 patients and analyzed as previously described [ 42 ]. Dietary intake was quantified and analyzed by a nation-customized nutrition database (PRODI ® 6 expert, Nutri-Science GmbH, Freiburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

Assessment of Intestinal Permeability and Inflammation Bio-Markers in Patients with Rheumatoid Arthritis

et al. 2023

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Increased intestinal permeability and inflammation, both fueled by dysbiosis, appear to contribute to rheumatoid arthritis (RA) pathogenesis. This single-center pilot study aimed to investigate zonulin, a marker of intestinal permeability, and calprotectin, a marker of intestinal inflammation, measured in serum and fecal samples of RA patients using commercially available kits. We also analyzed plasma lipopolysaccharide (LPS) levels, a marker of intestinal permeability and inflammation. Furthermore, univariate, and multivariate regression analyses were carried out to determine whether or not there were associations of zonulin and calprotectin with LPS, BMI, gender, age, RA-specific parameters, fiber intake, and short-chain fatty acids in the gut. Serum zonulin levels were more likely to be abnormal with a longer disease duration and fecal zonulin levels were inversely associated with age. A strong association between fecal and serum calprotectin and between fecal calprotectin and LPS were found in males, but not in females, independent of other biomarkers, suggesting that fecal calprotectin may be a more specific biomarker than serum calprotectin is of intestinal inflammation in RA. Since this was a proof-of-principle study without a healthy control group, further research is needed to validate fecal and serum zonulin as valid biomarkers of RA in comparison with other promising biomarkers.

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Section: Methodsmentioning

confidence: 99%

Assessment of Intestinal Permeability and Inflammation Bio-Markers in Patients with Rheumatoid Arthritis

et al. 2023

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“…The clinical and demographic data of patients are presented in Table 1. The baseline anthropometric, metabolic, and nutrition data have been published previously [40,41]. Further patient data (history and medication) are presented in Table S3.…”

Section: Patient Characteristicsmentioning

confidence: 99%

MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients

Heidt,

Pons-Kühnemann,

Kämmerer

et al. 2023

Nutrients

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Fatty acids, such as medium-chain fatty acids (MCFAs) and short-chain fatty acids (SCFAs), both important components of a normal diet, have been reported to play a role in bone-related diseases such as rheumatoid arthritis (RA). However, the role of medium-chain triglycerides (MCTs) has not been investigated in RA to date. The aim of this study was to investigate the effect of supplementation of regular diet with MCT with and without fiber on disease activity as measured with the SDAI (Simplified Disease Activity Index) in RA patients. A total of 61 RA patients on stable drug treatment were randomly assigned to a twice-daily control regimen or to a twice-daily regimen of a formulation containing medium-chain triglycerides (MCTs) 30 g/day for 8 weeks followed by a second twice-daily regimen of combining MCT (30 g/day) plus fiber (30 g/day) for an additional 8 weeks. The control group received a formulation containing long-chain triglycerides (LCTs) instead of MCTs. The preliminary results showed a significant reduction in SDAI from baseline to week 16 in the test group and a significant increase in β-hydroxybutyrate (BHB) levels, while no improvement in SDAI was observed in the control group.

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“…In our study, we observed a difference in zonulin antibody expression between the normal and asthma groups in the bronchial epithelium from the lung tissues. It has been proposed that increased intestinal permeability is present in allergic diseases including bronchial asthma [12], and zonulin antibody staining has been conducted in the intestinal epithelium of patients with various disorders [14][15][16]. However, studies on zonulin antibody expression in the bronchial epithelium have been less extensive than those on the intestinal epithelium, and the relationship between zonulin and airway inflammation still requires further evaluation.…”

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confidence: 99%

The Relationship Between Zonulin and Asthma: A Mouse Model Study

Hong,

Kang,

Chu

et al. 2023

J Rhinol

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Background and Objectives: Zonulin is a human protein that regulates intercellular tight junctions and increases the permeability of the intestinal epithelium. In light of the increasing focus on zonulin’s role in numerous chronic inflammatory diseases, this study aimed to investigate whether differences exist in serum zonulin levels and bronchial epithelium zonulin expression in vivo between asthma and normal groups, using a mouse model.Methods: Sixteen mice were utilized in this study, divided evenly between the normal and asthma groups. Serum zonulin levels, the expression of zonulin antibody in the bronchial epithelium, and serum cytokine levels were evaluated in both groups. Enzyme-linked immunosorbent assay and RNA in situ hybridization were utilized for the analysis.Results: The asthma group exhibited significantly higher levels of serum zonulin. High zonulin antibody expression was also observed in the bronchial epithelium of the asthma group. Given that our mouse model demonstrated a significant difference in interleukin (IL)-4 and IL-6 between the normal and asthma groups, zonulin may be associated not only with type 2 responses but also with various subtypes of asthma. Further studies are required to investigate this relationship in greater detail.Conclusion: Zonulin may play a role in the complex pathophysiology of asthma and could serve as a biomarker in various asthma-related situations.

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Nutrition Patterns and Their Gender Differences among Rheumatoid Arthritis Patients: A Descriptive Study

Cited by 5 publications

References 75 publications

Assessment of Intestinal Permeability and Inflammation Bio-Markers in Patients with Rheumatoid Arthritis

Assessment of Intestinal Permeability and Inflammation Bio-Markers in Patients with Rheumatoid Arthritis

MCT-Induced Ketosis and Fiber in Rheumatoid Arthritis (MIKARA)—Study Protocol and Primary Endpoint Results of the Double-Blind Randomized Controlled Intervention Study Indicating Effects on Disease Activity in RA Patients

The Relationship Between Zonulin and Asthma: A Mouse Model Study

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