Nutrition Support of the Hematopoietic Cell Transplant Recipient

Macris, Paula Charuhas; McMillen, Kerry K.

doi:10.1002/9781118416426.ch99

Cited by 5 publications

(8 citation statements)

References 78 publications

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“…Decreased oral intake, post-HSCT complications, and increased nutritional requirements lead to the need for individualized nutritional interventions. (11) The early identification of patients at nutritional risk minimizes the deleterious effects of malnutrition and/or overweight/obesity. Both are risk factors for complications and increased mortality, either or not associated with relapse in transplanted patients.…”

Section: ❚ Types Of Preparation (Conditioning) Regimensmentioning

confidence: 99%

“…(13) Initial and serial assessment of nutritional status is important, since it anticipates potential nutritional impacts of conditioning and other treatment-related toxicities, which affect nutrient intake, absorption and utilization. (11) ❚ OBESITy Excess weight (overweight and obesity) is an important risk factor for cardiovascular diseases, diabetes mellitus, among others. The prevalence of obesity increases every year.…”

Section: ❚ Types Of Preparation (Conditioning) Regimensmentioning

confidence: 99%

See 1 more Smart Citation

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults

Barban¹,

Simões²,

Moraes³

et al. 2020

Einstein (São Paulo)

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The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential. To emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to the nutritional assessment of the patient, the Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplant: Adults was prepared, aiming to standardize and update Nutritional Therapy in this area. Dietitians, nutrition physicians and hematologists from 15 Brazilian centers thar are references in hematopoietic stem cell transplant took part.

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Section: ❚ Types Of Preparation (Conditioning) Regimensmentioning

confidence: 99%

Section: ❚ Types Of Preparation (Conditioning) Regimensmentioning

confidence: 99%

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults

Barban¹,

Simões²,

Moraes³

et al. 2020

Einstein (São Paulo)

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“…Values lower than 2.5mg/dL are potentially associated with intravascular volume overload, systemic capillary extravasation syndrome, diarrhea or liver diseases. (47) • Pre-albumin: in serum, prealbumin carries about 70% of thyroxin, and is also the carrier of retinolbinding protein (RBP), both of which are decreased in energy-protein malnutrition, as well as in infections, cirrhosis, hepatitis, inflammation, stress and chronic diseases. As a marker of metabolic stress, it can help determine the need for nutritional intervention.…”

Section: Nutritional Statusmentioning

confidence: 99%

“…(48) Levels <10mg/dL are considered abnormal in children. (47) • Transferrin: beta-globulin synthesized in the liver and responsible for transporting certain nutrients, particularly iron. It has an average life of 4 to 8 days, and thus abnormal levels can be detected much sooner than for albumin, in case of protein depletion, and this makes it an important tool for diagnosing subclinical malnutrition.…”

Section: Nutritional Statusmentioning

confidence: 99%

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents

Nabarrete¹,

Pereira²,

Garófolo³

et al. 2021

Einstein (São Paulo)

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The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian Society of Bone Marrow Transplantation.

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“…45 Nötropeni durumunda bağı-şıklık sistemi baskılanması nedeni ile besinsel kaynaklı enfeksiyonlardan kaçınmak için doku uyumu sağlanana kadar düşük bakterili ve nötropenik diyetler uygulanmaktadır. 46 Nötropenik hastalarda nötropeninin şiddeti hastanın enfeksiyon açısından taşıdığı riski belirlemede yol göstericidir. 45 Amerikan Enteral Parenteral Beslenme Derneği (ASPEN)'nin hastaların nötropeni durumunda güvenli besin tüketimi ile ilgili beslenme önerileri almalarının enfeksiyon riskini azaltabileceğine dair önerisi de bulunmuştur.…”

Section: Nötropeni̇k Di̇yetlerunclassified

Hematopoietic Stem Cell Transplantation and Current Nutritional Approaches: Review

Metin¹,

Dere²

2017

Turkiye Klinikleri J Pediatr

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ök hücre nakli (KHN); kemik iliği hasar görmüş hastalarda kemik iliği fonksiyonunun yeniden yapılandırılması amacıyla intravenöz (IV) ya da oral yüksek doz kemoterapi veya radyoterapiyi takiben Hematopoetik Kök Hücre Nakli ve Güncel Beslenme Yaklaşımları Ö ÖZ ZE ET T Hematopoetik kök hücre nakli (KHN); lösemilerin, solid tümörlerin, bazı hematolojik, nö-rolojik, metabolik ve otoimmün hastalıkların tedavisinde kullanılmaktadır. Hastanın kendi kök hücrelerinin kendisine verilmesiyle (otolog kök hücre nakli) veya başka bir vericiden hastaya kök hücre transfer edilmesiyle (allojeneik kök hücre nakli) yapılabilmektedir. KHN sonrası, donörden alınan kök hücrelerle birlikte verilen sağlıklı T-lenfositlerin aracılık ettiği, şiddetli immünolojik reaksiyon sonucu görülen organ disfonksiyonu ile karakterize, ortaya çıkış zamanına göre akut veya kronik seyreden graft-versus-host-hastalığı (GVHH) gelişebilmekte ve bu durum en önemli mortalite ve morbidite sebebi olarak kabul edilmektedir. Hastalarda KHN sonrası görülen komplikasyonları (kusma, diyare, oral mukozit, anoreksiya) azaltmak, iyileşme sürecini hızlandırmak, hematopoezi desteklemek, doku reddini ve GVHH'ı önlemek için beslenme durumunun saptanması ve beslenme desteğinin sağlanması gerekmektedir. Bu amaçla oral alımın sağlanamadığı ya da yetersiz sağlanabildiği durumlarda enteral, total parenteral ya da kombine beslenme seçenekleri değerlendirilmeli, hastanın enerji, protein, lipit, karbonhidrat, vitamin ve mineral gereksinimleri sağlanmalıdır. Son dönemde bu hasta grubunda yapılan çalışmalarda, omega-3 yağ asitleri, glutamin, D vitamini ve prebiyotik/probiyotiklerin olumlu etkileri bildirilmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Hematopoetik kök hücre transplantasyonu; beslenme tedavisi; enteral beslenme; parenteral beslenme; graft vs host hastalığı A AB BS ST TR RA AC CT T Hematopoietic stem cell transplantation (HSCT) which is used in the treatment of solid tumors, some hematologic, neurologic, metabolic and autoimmune diseases can be operated autologous (involving tissues or cells that are genetically similar) or allogeneic (involving tissues or cells that are genetically dissimilar). Healthy T-lymphocyte-mediated acute or chronic graft-versus-host-disease (GVHD) according to stem cells taken from a donor can result in severe immunological reaction characterized by organ dysfunction may be seen after HSCT. This complication is considered as the most important cause of morbidity and mortality. Determining nutritional status and improving by nutritional support is essential in order to reduce complications (vomiting, diarrhea, oral mucositis, anorexia), accelerate the healing process, prevent rejection, support emerging hematopoiesis and prevent GVHD. For this purpose, total parenteral or enteral nutrition or combined options should be considered when oral feeding is not enough. The patient's energy, protein, lipid, carbohydrate, vitamin and mineral requirements must be provided. Recent studies reported favourable effects of omega-3 fatty aci...

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Nutrition Support of the Hematopoietic Cell Transplant Recipient

Cited by 5 publications

References 78 publications

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents

Hematopoietic Stem Cell Transplantation and Current Nutritional Approaches: Review

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