Nutritional and Biochemical Parameters Among Multiple Sclerosis Patients: A Case-Control Study

Abstract

BackgroundThe pathogenesis and prognosis of multiple sclerosis (MS) is an area of active medical research. Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression. This study aimed to compare the nutritional status and biochemical profile of patients with and without MS. MethodologyThis case-control study included a total of 112 participants (56 in the control group and 56 in the MS group). The participants' socioeconomic and demographic profiles, nutritional status, and biochemical details were all gathered using history, patient files, and records. The effect of these parameters on the presence of MS was evaluated using a decision tree model. Student's t-test and Mann-Whitney U test were performed to compare these parameters. ResultsA decision tree model was developed with an accuracy rate of 86.52%. The vitamin and mineral intake of the groups showed significant statistical differences (p = 0.001). The differences were important in terms of biochemical parameters, especially serum levels of 25-dihydroxycholecalciferol and potassium. ConclusionsThe key parameters that varied between MS patients and the control group, according to the constructed decision tree, were serum levels of 25-dihydroxycholecalciferol, magnesium, calcium, potassium, and carbohydrate intake. Nutritional measures against MS can be taken based on the decision tree.

The Interplay of Sports and Nutrition in Neurological Health and Recovery

“…In these patients, apart from controlling nutrition for the obvious benefits of maintaining microbial homeostasis, it is also important to keep in mind that these patients are more susceptible to osteoporosis, so the diet should be focused on the inclusion of calcium and vitamin D in abundance [29]. Other studies have been carried out that focused on the nutritional and metabolomic profile in neurological pathologies such as MS and ALS, finding dysbiosis associated with the evolution of the pathology [30,31]. These results indicate a promising line of study for the approach to neurological diseases.…”