BackgroundThe pathogenesis and prognosis of multiple sclerosis (MS) is an area of active medical research. Dietary and biochemical parameters such as serum 25-dihydroxycholecalciferol, magnesium, and potassium play a role in disease progression. This study aimed to compare the nutritional status and biochemical profile of patients with and without MS. MethodologyThis case-control study included a total of 112 participants (56 in the control group and 56 in the MS group). The participants' socioeconomic and demographic profiles, nutritional status, and biochemical details were all gathered using history, patient files, and records. The effect of these parameters on the presence of MS was evaluated using a decision tree model. Student's t-test and Mann-Whitney U test were performed to compare these parameters. ResultsA decision tree model was developed with an accuracy rate of 86.52%. The vitamin and mineral intake of the groups showed significant statistical differences (p = 0.001). The differences were important in terms of biochemical parameters, especially serum levels of 25-dihydroxycholecalciferol and potassium. ConclusionsThe key parameters that varied between MS patients and the control group, according to the constructed decision tree, were serum levels of 25-dihydroxycholecalciferol, magnesium, calcium, potassium, and carbohydrate intake. Nutritional measures against MS can be taken based on the decision tree.

Growing research has shown that multiple sclerosis (MS) patients have lower levels of 25-OHvitD3 than healthy controls. The purpose of this study was to evaluate the serum concentration of 25-OHvitD3, CYP24Alenzyme in MS patients and calcium-phosphate metabolism indices depending on the different disease lines and gender. Furthermore, we elevated the relationship between study parameters and gender with degree of motor disability according to the Expanded Disability Status Scale (EDSS). Serum of 110 Iraqi MS patients (50 male and 60 female) and 63 healthy individuals (30 male and 33 female) as control groups were used in our study. Serum level of 25-OHvitD3, CYP24A1and PTH were measured by ELISA. Serum level for calcium, phosphorus and magnesium were performed with a BioSystems A25 and A15 analyzers. Significantly lower level of CYP24A1 and 25-OHvitD3 was found in MS patients when compared to control groups. The Levels of CYP24A1 and 25-OHvitD3 were positively correlated in female and significantly decreased with EDSS in female groups. Also, in MS patients a highly significant decrease in calcium, a considerable increase in level of PTH, phosphorous and magnesium. In this study the negative correlation between 25-OHvitD3 and the degree of motor disability, according to EDSS in MS patients was confirmed. We identified a non-significant difference in the level of 25-OHvitD3 regarding on gender. Still, we confirmed the association between gender and MS disease development regarding the levels of 25-OHvitD3, PTH and phosphorus.

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