Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

Abstract

AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets. METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases. We manually screened articles that examined nutritional and health outcomes (e.g. , growth, disease activity, gastrointestinal impairment, mortality, and economic impact) among various patient groups receiving semi-elemental diets. This review focused on full-text articles of randomized controlled clinical trials and other intervention studies, but pertinent abstracts and case studies were also included. Results pertaining primarily to tolerance, digestion, and absorption were summarized for each patient population in this systematic review.

Reduction in Healthcare Utilization With Transition to Peptide‐Based Diets in Intolerant Home Enteral Nutrition Patients

“…Although PepT1 expression is mostly in the small intestine, in inflammatory bowel disease and short‐bowel syndrome, colonic expression of PepT1 is upregulated, allowing for increased absorption of dipeptides and tripeptides 16,17 . This may provide a distinct advantage to PBDs in terms of protein absorption, since PBDs typically contain whey protein that is enzymatically hydrolyzed to yield dipeptide and tripeptide chains 18 …”

Guidelines for Clinical Nutrition in Inflammatory Bowel Disease

“…Općenito, oligomerni enteralni pripravci preporučuju se u fazama aktivne upalne bolesti crijeva, u situacijama teške malapsorpcije i maldigestije te kod stenoza crijeva. 52 Nekoliko je studija uspoređivalo učinak različitih vrsta enteralnih pripravaka (monomerni, oligomerni ili polimerni) u aktivnom CB-u. Cochraneova metaanaliza 10 studija nije pokazala statistički značajnu razliku između pacijenata liječenih monomernom i nemonomernom prehranom (oligomerna ili polimerna).…”

Knowledge of Constituent Ingredients in Enteral Nutrition Formulas Can Make a Difference in Patient Response to Enteral Feeding

“…This allows the liver and other organs to make optimal use of these amino acids for protein synthesis and other metabolic functions such as the synthesis of purines and pyrimidines. Consequently, the indication for hydrolyzed protein or amino acids is limited to severe pancreatic insufficiency and small bowel malfunction . Even in these situations, the benefit of predigested protein is uncertain.…”

“…Consequently, the indication for hydrolyzed protein or amino acids is limited to severe pancreatic insufficiency and small bowel malfunction. 55,56 Even in these situations, the benefit of predigested protein is uncertain. Moreover, some EFs that contain hydrolyzed protein or amino acids are more expensive, without providing the desired clinical benefit.…”