Nutritional and occupational factors influencing the risk of Parkinson's disease: A case‐control study in southeastern Sweden

Fall, Per-Arne; Fredrikson, Mats; Axelson, Olav; Granérus, Ann‐Kathrine

doi:10.1002/1531-8257(199901)14:1<28::aid-mds1007>3.3.co;2-f

Cited by 72 publications

(123 citation statements)

References 26 publications

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“…Dopaminergic neurons are thought to have high basal levels of oxidative stress due to the highly reactive nature of dopamine (9)(10)(11). Exposure to environmental agents that induce further oxidative stress leads to selective dopaminergic neuron degeneration in animal models (6,(12)(13)(14)(15)(16), reflective of increased risk by such agents for Parkinson's disease in humans (5,12,(17)(18)(19)(20)(21)(22).…”

mentioning

confidence: 99%

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

Meulener

Xu²,

Thomson³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

224

191

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Inherited mutations in PARK7 , the gene encoding DJ-1, are associated with loss of protein function and early-onset parkinsonism. Like human DJ-1 (hDJ-1), Drosophila DJ-1b protects against oxidative insult and is modified with oxidation. We demonstrate that hDJ-1 rescues flies mutant for DJ-1b, and that a conserved cysteine residue in the fly protein (C104, analogous to C106 in hDJ-1) is critical for biological antioxidant function in vivo . Targeted mutagenesis suggests that modification of DJ-1b at this residue inactivates the protective activity of the protein against oxidative stress. Further studies show that DJ-1 modification increases dramatically with age in flies, mice, and humans, with aged flies showing strikingly increased susceptibility to oxidative stress and markedly enhanced DJ-1b modification upon oxidative challenge. Overoxidation of DJ-1 with age and exposure to oxidative toxins may lead to inactivation of DJ-1 function, suggesting a role in susceptibility to sporadic Parkinson’s disease.

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mentioning

confidence: 99%

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

Meulener

Xu²,

Thomson³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

224

191

View full text Add to dashboard Cite

show abstract

“…We also accounted for the confounding effect of socioeco- O observed number of cases; SIR standardized incidence ratio; CI confidence interval nomic status. Socioeconomic status is a risk factor associated with PD [9]. Additionally, the data in the Swedish Hospital Discharge Register are highly complete.…”

Section: Discussionmentioning

confidence: 99%

“…Social isolation and low levels of emotional support are related to specific mood disorders and PD [24]. Furthermore, unhealthy behavior in psychiatric patients, such as smoking, an unhealthy diet, and physical inactivity, possible mechanisms for PD, and low socioeconomic status are related to both psychiatric disorders and PD [9,18,27]. In addition, biological mechanisms are likely involved in the development of both psychiatric disorders and PD.…”

Section: Discussionmentioning

confidence: 99%

Impact of psychiatric disorders on Parkinson's disease

Sundquist

Hwang

et al. 2007

J Neurol

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“…There have been a wide range of reports on PD and dietary factors, such as those focusing on excessive intake of animal lipids [8][9][10][11], insufficient intake of nicotinic acid (niacin) [12][13][14], and insufficient intake of antioxidants [20].A study in Seattle by Anderson et al [11] with 4 groups of subjects consuming different amounts of animal lipids indicated that the risk of PD increased as animal lipid intake increased, with an odds ratio of 3.30 for those in the group consuming the largest amount.The authors of the report proposed that this could be due to the large effect of oxidative stress caused by animal lipid intake.In a cross-sectional study in Rotterdam focusing on the relationship between antioxidant intake and PD [15], the results indicated that is was harder for subjects in a group taking 10 mg of vitamin E per day to develop PD (OR 0.5, 95 % confidence interval; 0.2-0.9). Due to problems with the studies, however, the relationship between PD and dietary factors has as yet not been confirmed.…”

Section: ■ Parkinson's Disease and Dietary Factorsmentioning

confidence: 99%

Life style risks of Parkinson?s disease: Association between decreased water intake and constipation

Ueki¹,

Otsuka²

2004

J Neurol

130

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Gastrointestinal dysfunction, especially constipation, is one of the major problems in the daily life of patients with Parkinson's disease (PD). About 60 to 80% of PD patients suffer from constipation. Several studies have proven that constipation appears about 10 to 20 years prior to motor symptoms. More recently, Abbott et al. have found from a large scale prospective study that lower frequency bowel movements predict the future risk of PD. Furthermore, Braak et al. have found that Lewy neuritis and Lewy bodies, the hallmarks of PD pathology, appear in the dorsal nucleus of vagus in the earliest stage of the disease and then extend upward through the brain stem to reach the substantia nigra in the third stage. They also hypothesize that some yet undefined toxins break through the mucosal barrier of the intestine and are incorporated into the axon terminal of the vagus nerve and transported in a retrograde manner to the vagus nucleus. In this study, we assessed bowel movements and nutritional status in Japanese patients with PD. We found that intake of water was significantly decreased in PD patients from early life and associated with their constipation. Ninety four patients with PD (M 50, F 44) were enrolled. Nutritional status was assessed using the Self-administered Diet History Questionnaire (DHQ). Total water intake was calculated from the consumption of coffee, green tea, and tea. We also questioned the behavior of water drinking from the early stage of life. The questionnaire for bowel movements concerned the frequency of defecation, age of onset of constipation, and age of onset of motor dysfunction. Less than one bowel movement in 3 days was defined as constipation. The nutritional status of PD patients did not differ significantly from those of controls though several studies have shown excess intake of animal fats or reduced consumption of coffee are risks in PD. In contrast, water intake was significantly lower in PD patients than controls (604.0+/-377.2 ml/d vs 909.5+/-531.6 ml/d; P<0.0001). Interestingly, PD patients tended not to feel thirsty and thus they had no desire to drink water throughout their life. Seventy four patients out of 94 (78.7 %) complained of constipation. Mean bowel frequency was once per 3.3+/-1.1 days and 71.1% of patients were defined as having constipation. Women suffered from constipation more frequently than men (82.4% vs 61.9 %). In 33 patients out of 74 (44.6 %), onset of constipation preceded motor disturbance by an average time of 18.1+/-18.8 years. Furthermore, the amount of water intake correlated inversely with the severity of constipation and the depletion of water intake preceded constipation in most cases. The present results support previous findings that constipation precedes the onset of motor dysfunction in PD. To our knowledge, this is the first report to point out latent water depletion in PD patients. It is not certain at present whether coffee or caffeine themselves are the protective factor for PD or alternatively the amount of water in coffee drinking...

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Nutritional and occupational factors influencing the risk of Parkinson's disease: A case‐control study in southeastern Sweden

Cited by 72 publications

References 26 publications

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

Impact of psychiatric disorders on Parkinson's disease

Life style risks of Parkinson?s disease: Association between decreased water intake and constipation

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