Nutritional and Socioeconomic Factors in Relation to Prostate Cancer Mortality: a Cross-National Study

Hébert, James R.; Hurley, Thomas G.; Olendzki, Barbara C.; Teas, Jane; Ma, Yunsheng; Hampl, Jeffrey S

doi:10.1093/jnci/90.21.1637

Cited by 313 publications

(177 citation statements)

References 35 publications

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“…Few epidemiologic studies have been conducted evaluating the association between nut consumption and cancer. An ecological study showed that prostate cancer mortality was inversely associated with nuts and oilseed consumption [27]. Moreover, findings from prospective studies suggest inverse associations between nut consumption and colorectal or endometrial cancer, especially in women [28]–[31].…”

Section: Discussionmentioning

confidence: 99%

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial

Guasch‐Ferré

Bulló

Martínez‐González

et al. 2013

BMC Med

145

148

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BackgroundProspective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person.MethodsWe evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED (‘PREvención con DIeta MEDiterránea’) study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality.ResultsDuring a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend <0.05, all). Compared to non-consumers, subjects consuming nuts >3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts >3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66).ConclusionsIncreased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165.Trial registrationClinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.

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Section: Discussionmentioning

confidence: 99%

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial

Guasch‐Ferré

Bulló

Martínez‐González

et al. 2013

BMC Med

145

148

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“…5,6 Absorbance (450 nm The results of epidemiologic studies indicate that dietary factors may be the main reason that Western populations run a higher risk of prostate cancer than do Asian populations. 2,3 Recently, curcumin has become a focus of interest with regard to its possible antitumor effects in prostate cancer. [12][13][14][15][16][17][18] This study shows for the first time, to our knowledge, that curcumin exerts an inhibitory effect on the invasiveness of DU-145 prostate cancer cells, and confirms this via both in vitro and in vivo testing.…”

Section: Discussionmentioning

confidence: 99%

“…This difference has been proposed to be attributable to the dietary consumption of abundant amounts of plant-based foods in Asia, foods that are often also rich in phytochemicals. 2,3 The majority of prostate cancer deaths occur in patients exhibiting metastases. In order to metastasize, degradation of the extracellular matrix (ECM) and basement membrane must occur.…”

Section: Introductionmentioning

confidence: 99%

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Hong

Ahn

Bae

et al. 2006

Prostate Cancer Prostatic Dis

152

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Curcumin has become a focus of interest with regard to its antitumor effects in prostate cancer; however, the effects of this agent on invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs) are important prerequisite for tumor invasion and metastasis. In this study, we evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in both in vitro and in vivo. We utilized zymography and ELISA in order to determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to assess cellular invasion. We developed a xenograft model to examine tumorigenicity. Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro. Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic nodules in vivo were significantly fewer in the curcumintreated group than untreated group. Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.

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“…1,2 In general, foods rich in saturated fat and calories are considered as promoters of prostate cancer, 3,4 whereas vegetables and fruits, including selenium, vitamins A, E, D and C, and isoflavones are inhibitors. [5][6][7][8] It is strongly suggested that the recent significant increase in the incidence of prostate cancer, as well as cardiovascular diseases and diabetes mellitus in Japan may be due to the increased habitual consumption of high-calories high-fat food. Nonetheless, the morbidity of prostate cancer among the Japanese is still significantly lower than among the Caucasian, African and Hispanic people.…”

Section: Introductionmentioning

confidence: 99%

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Fujimoto

Tanaka

Hirao

et al. 2008

Prostate Cancer Prostatic Dis

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Racial differences in the incidence of prostate cancer are manifest worldwide, possibly due to the different dietary habits. To elucidate the relationship between the recent trend of phytoestrogenic isoflavone intake and the increased incidence of prostate cancer in Japan, we conducted an agestratified dietary survey of soybean foods in 102 Japanese healthy men (age range: 10-59 years) and measured the serum isoflavones and equol levels in them and 100 Korean healthy men. The intergroup comparison among the age-stratified groups showed significant differences in the daily intake of genistein and daidzein between the teenager group and the other groups of age^30 years (Po0.05). In the Japanese study, the proportion of equol producers in the teenager group was 10%, being significantly the lowest among the age-stratified groups. The proportions of equol producers in the age-stratified groups from 10 to 49 years were also significantly lower than those in the fifties. The equol non-producers consumed significantly less amounts of isoflavones than the equol producers. In the Korean study, the proportions of equol producers were 45% in the teenager and 40% in the twenties and thirties, being significantly lower than in the forties (80%) and fifties (65%). The decreased intake of isoflavones, low serum level of equol and low incidence of equol production in the young generation may become potential risk factors for prostate cancer not only in Japan but also in Korea in the near future. Elucidating the mechanism of equol production may be promising in developing strategies for chemoprevention against prostate cancer.

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Nutritional and Socioeconomic Factors in Relation to Prostate Cancer Mortality: a Cross-National Study

Cited by 313 publications

References 35 publications

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

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