1971
DOI: 10.1079/bjn19710046
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Nutritional aspects of amino acid metabolism

Abstract: I . Experiments were done to find whether the rat liver can be maintained in a satisfactory condition when perfused with oxygenated Krebs-Ringer bicarbonate buffer without added protein or red cells.2. The condition and performance of the liver in this system were assessed from measurements made to ascertain its general condition or viability, its basal characteristics and its response to added substrates.3. It was found that the rapid flow-rate of the medium through the livers and the efficient oxygenation of… Show more

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Cited by 31 publications
(5 citation statements)
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“…However, the exact factors remain to be determined. ATP concentrations were comparable with values found in vivo (Bloxam, 1971;Bucher, et al, 1964) and increased during up to 12h of incubation (Table 3). Even after 24h of incubation, ATP concentrations were above 2,umol/g of hepatocytes indicating that the energy reserve of the cell was adequate for protein synthesis.…”
Section: Albumin Fibrinogen and Transferrin Synthesissupporting
confidence: 87%
See 1 more Smart Citation
“…However, the exact factors remain to be determined. ATP concentrations were comparable with values found in vivo (Bloxam, 1971;Bucher, et al, 1964) and increased during up to 12h of incubation (Table 3). Even after 24h of incubation, ATP concentrations were above 2,umol/g of hepatocytes indicating that the energy reserve of the cell was adequate for protein synthesis.…”
Section: Albumin Fibrinogen and Transferrin Synthesissupporting
confidence: 87%
“…ATP concentrations are given in Table 3. The ATP concentrations whether expressed per weight of cells or in terms of cell numbers are comparable with those obtained in vivo (Bloxam, 1971;Bucher et al, 1964). After this 12h, the ATP concentrations gradually fell over the next 36h to about 55 % of the peak value.…”
Section: Preliminary Experimentssupporting
confidence: 68%
“…The endogenous rate of uric acid output (0.078,umol/min per g of liver) by the perfused chick liver was similar to endogenous rates of urea production in the perfused rat liver recorded by Hems et al (1966) (0.10,pmol/min per g of liver) and Bloxam (1971) (0.13,umol/min per g of liver). Endogenous rates of uric acid output in the chick in vivo (anaesthetized) are 0.19 ± 0.02 (20),umol/min per g of liver (E. Barratt, P. J.…”
Section: Amino Acid Addedsupporting
confidence: 86%
“…The liver, when exposed to these fluctuations , modulates them, thus allowing changes in the peripheral blood to occur at a slower rate and to a lesser extent. This has also been demonstrated tii perfusion studies (8) in which rat livers were perfused with variable concentrations of amino acids, the final concentrations of most of the amino acids in the effluent tended to a fixed value, whether the initial concentration was high or low. Branched chain amino acids, which are largely metabolized in muscle, were exceptions.…”
Section: Editorialmentioning
confidence: 65%