Nutritional Deficiencies in Morbidly Obese Patients: A New Form of Malnutrition?

Kaidar‐Person, Orit; Person, Benjamin; Szomstein, Samuel; Rosenthal, Raúl J.

doi:10.1007/s11695-007-9350-5

Cited by 136 publications

(38 citation statements)

References 57 publications

(74 reference statements)

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“…Another positive determinant of UE function was a higher BMI, which seems to be counterintuitive because, on the one hand, it is associated with arms that weigh more, requiring more strength to lift the arms. On the other hand, a higher BMI is often related to a better nutritional status (even though protein loss may still occur when BMI is high [16, 17]) and malnutrition occurs more often in people with a low BMI, as it is associated with dysphagia, typically occurring in the later stages of DMD [7, 30]. Malnutrition can be related to a lack of energy, increased fatigability, reduced muscle strength, and muscle wasting leading to loss of functional capacity [7, 20].…”

Section: Discussionmentioning

confidence: 99%

Variables associated with upper extremity function in patients with Duchenne muscular dystrophy

Janssen

Hendriks²,

Geurts

et al. 2016

J Neurol

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Preserving upper extremity (UE) function in patients with Duchenne muscular dystrophy (DMD) is extremely important as it is related to independence and quality of life. For clinical decision making, knowledge of variables associated with UE function is necessary. This knowledge is, however, limited. Therefore, this study aims to gain more insight into the variables associated with UE function in DMD. Data from an international web-based questionnaire on UE function, obtained from 213 DMD patients, were used. Six dependent variables regarding UE function were used in multivariable linear regression analyses. In addition, 26 independent variables regarding patient characteristics, medication, therapy, supportive aids, pain, stiffness and participation were used. Twelve independent variables showed a significant relation to UE function. Variables with a negative relation to UE function were: later disease stage, occurrence of scoliosis, higher age, use of UE splints, more frequent stiffness complaints, more limitations due to stiffness, more frequent elbow pain, and having physical therapy. A positive relation with UE function was seen for going to school or work, use of corticosteroids, higher BMI, and higher age at diagnosis. These variables explained 56-81 % of the variation of the different measures of UE function. Knowledge of variables associated with UE function is very important in the clinical management of DMD patients. The results of this study suggest that corticosteroid use and participation in school and work related activities are positively related to UE function in DMD patients, as well as reducing pain and stiffness and preventing scoliosis.

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Section: Discussionmentioning

confidence: 99%

Variables associated with upper extremity function in patients with Duchenne muscular dystrophy

Janssen

Hendriks²,

Geurts

et al. 2016

J Neurol

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“…Due to a limited diet for certain micronutrients, a great number of patients already develop these deficiencies prior to a bariatric procedure [14, 15]. Because LSG is a restrictive procedure and therefore lacks the malabsorptive component of for example a RYGB, the risk for developing deficiencies after surgery is considered low and therefore often not tested.…”

Section: Discussionmentioning

confidence: 99%

“…Although only eight patients developed abnormal MCVs it is likely that, with 23 (43%) patients developing iron deficiency and eight (15%) patients developing folate deficiency, these two deficiencies eventually contribute to the number of anemic patients. The iron deficiencies found can be partially explained by pre-existing shortage [14], but also by the LSG itself. Iron needs to be transformed to an absorbable form by hydrochloric acid in the normal stomach [11, 14].…”

Section: Discussionmentioning

confidence: 99%

The Gastric Sleeve: Losing Weight as Fast as Micronutrients?

2010

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BackgroundRecently, the laparoscopic sleeve gastrectomy (LSG) has become popular as a single-stage procedure for the treatment of morbid obesity and its co-morbidities. However, the incidence of micronutrient deficiencies after LSG have hardly been researched.MethodsFrom January 2005 to October 2008, 60 patients underwent LSG. All patients were instructed to take daily vitamin supplements. Patients were tested for micronutrient deficiencies 6 and 12 months after surgery.ResultsAnemia was diagnosed in 14 (26%) patients. Iron, folic acid, and vitamin B12 deficiency was found in 23 (43%), eight (15%), and five (9%) patients, respectively. Vitamin D and albumin deficiency was diagnosed in 21 (39%) and eight (15%) patients. Hypervitaminosis A, B1, and B6 were diagnosed in 26 (48%), 17 (31%), and 13 (30%) patients, respectively.ConclusionsDue to inadequate intake and uptake of micronutrients, patients who underwent LSG are at serious risk for developing micronutrient deficiencies. Moreover, some vitamins seem to increase to chronic elevated levels with possible complications in the long-term. Multivitamins and calcium tablets should be regarded only as a minimum and supplements especially for iron, vitamin B12, vitamin D, and calcium should be added to this regimen based on regular blood testing.

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“…Modern agriculture and food processing techniques lead to a relative reduction in the micronutrient content of common foods [4]. Despite an excess of dietary calorie intake, obese individuals have relatively high rates of micronutrient deficiencies [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

The Malnutrition of Obesity: Micronutrient Deficiencies That Promote Diabetes

2012

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Obesity and diabetes are increasing in prevalence worldwide. Despite excessive dietary consumption, obese individuals have high rates of micronutrient deficiencies. Deficiencies of specific vitamins and minerals that play important roles in glucose metabolism and insulin signaling pathways may contribute to the development of diabetes in the obese population. This paper reviews the current evidence supporting this hypothesis.

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Nutritional Deficiencies in Morbidly Obese Patients: A New Form of Malnutrition?

Cited by 136 publications

References 57 publications

Variables associated with upper extremity function in patients with Duchenne muscular dystrophy

Variables associated with upper extremity function in patients with Duchenne muscular dystrophy

The Gastric Sleeve: Losing Weight as Fast as Micronutrients?

The Malnutrition of Obesity: Micronutrient Deficiencies That Promote Diabetes

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