Nutritional Derangements in Advanced Non-Small Cell Lung Cancer Patients: Prevalence and Impact on Treatment Outcome

Trestini, Ilaria; Sperduti, Isabella; Sposito, Marco; Kadrija, D.; Drudi, A.; Tregnago, Daniela; Avancini, Alice; Gkountakos, Anastasios; Carbognin, Luisa; Lanza, Massimo; Santo, Antonio; D’Onofrio, Mirko; Bria, Emilio; Milella, Michèle; Pilotto, Sara

doi:10.1016/j.nut.2020.110908

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“…Additionally, we manifested that lower TC levels indicated a poor OS in patients with LUSC. Cholesterol is essential for maintaining the integrity, fluidity, and function of the cell membrane, including signal transduction 19 , 20 . Low cholesterol has been proposed to be associated with suppressed immunity, upregulated activity or responsiveness of the mevalonate pathway and increased activity of nuclear transcription factor NF-κB, promoting the initiation and progression of cancer 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that most patients with non-small cell lung cancer suffer from malnutrition 19 . In addition, even patients with normal nutrition may suffer from malnutrition in the early postoperative period, which may lead to poor wound healing and reduced immunity after surgery, resulting in an increased risk of postoperative complications including bronchial leakage, postoperative infection, respiratory asthenia, and ultimately poor OS and progression-free survival 31 , 32 .…”

Section: Discussionmentioning

confidence: 99%

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The clinical significance of preoperative serum triglyceride, high-density lipoprotein, and low-density lipoprotein levels in lung squamous cell carcinoma

Wang

et al. 2022

Sci Rep

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To evaluate the prognostic role of the preoperative plasma lipid profile, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with lung squamous cell carcinoma (LUSC) who underwent complete resection. Clinical data, including preoperative plasma profile levels, were retrospectively collected and reviewed in 300 patients with LUSC who underwent radical lung resection between 2016 and 2017. The overall survival (OS) and disease-free survival (DFS) were assessed by the Kaplan–Meier method and the Cox proportional hazards regression model. TG ≤ 1.35, HDL-C ≤ 1.17, and LDL-C ≤ 2.32 were deemed as independent preoperative risk factors for OS, and HDL-C ≤ 1.17 was an independent preoperative risk factor for DFS. In the multivariate analyses involving OS and DFS, a decreased HDL-C level was significantly associated with worse OS (HR, 0.546; 95% CI, 0.380–0.784, P = 0.001) and DFS (HR, 0.644; 95% CI, 0.422–0.981, P = 0.041). Additionally, an increased TG (HR, 0.546; 95% CI, 0.366–0.814, P = 0.003) or LDL-C (HR, 0.652; 95% CI, 0.456–0.933, P = 0.019) level was significantly associated with better OS. In patients with LUSC, decreased levels of HDL-C may predict worse outcomes for both DFS and OS, while increased TG or LDL-C levels may predict better OS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%