The clinical significance of preoperative serum triglyceride, high-density lipoprotein, and low-density lipoprotein levels in lung squamous cell carcinoma

Abstract

To evaluate the prognostic role of the preoperative plasma lipid profile, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with lung squamous cell carcinoma (LUSC) who underwent complete resection. Clinical data, including preoperative plasma profile levels, were retrospectively collected and reviewed in 300 patients with LUSC who underwent radical lung resection between 2016 and 2017. The overall survival (OS) and disease-free survival (DFS) were assessed by the Kaplan–Meier method and the Cox proportional hazards regression model. TG ≤ 1.35, HDL-C ≤ 1.17, and LDL-C ≤ 2.32 were deemed as independent preoperative risk factors for OS, and HDL-C ≤ 1.17 was an independent preoperative risk factor for DFS. In the multivariate analyses involving OS and DFS, a decreased HDL-C level was significantly associated with worse OS (HR, 0.546; 95% CI, 0.380–0.784, P = 0.001) and DFS (HR, 0.644; 95% CI, 0.422–0.981, P = 0.041). Additionally, an increased TG (HR, 0.546; 95% CI, 0.366–0.814, P = 0.003) or LDL-C (HR, 0.652; 95% CI, 0.456–0.933, P = 0.019) level was significantly associated with better OS. In patients with LUSC, decreased levels of HDL-C may predict worse outcomes for both DFS and OS, while increased TG or LDL-C levels may predict better OS.

Prognostic role of preoperative serum total cholesterol and high-density lipoprotein in lung adenocarcinoma

“…In recent years, research on the correlation between serum cholesterol levels and the risk of lung cancer has gradually increased. Our recent previous study found that preoperative low cholesterol levels are associated with poor prognosis in lung squamous cell carcinoma (7), and Zhang et al also reported that high cholesterol levels reduce the risk of death in patients with advanced NSCLC and who have the epidermal growth factor receptor (EGFR) gene mutation (20), thus aligning with our results.…”

“…The risk factors for survival were identi ed using the Cox proportional hazards model. The association between serum lipid levels and clinicopathological parameters, including age, gender, history of smoking, history of drinking alcohol, T stage, lymph node metastasis, TNM stage, recurrence, and death, was tested with the chi-square test (7). In all of the statistical methods, p < 0.05 denoted a statistically signi cant difference.…”

“…Several recent studies have con rmed that dyslipidemia is associated with an increased risk of tumor recurrence and reduced survival for multiple cancer types (7,12,13). Our previous study found that preoperative lipid distribution has an important impact on the prognosis of patients with lung squamous cell carcinoma (7), but there is little evidence about the effect of lipid pro les on prognosis of patients with LUAD.…”

“…For example, Zhang L et al found that PSMD14 may serve as a potential prognostic marker and therapeutic target for LUAD patients (5), and Sun S. et al suggested that downregulation of m6A reader YTHDC2 may promote tumor progression and predict poor prognosis in LUAD(6). Due to the high cost and complicated detection equipment required for existing methods, the development of accurate, fast, and convenient predictive biomarkers for the identi cation of patients with a high risk of metastasis and recurrence is emerging as a signi cant area of investigation, and it may present an opportunity for improving clinical prognosis and postoperative quality of life (7).…”

“…Additionally, studies have associated low high-density lipoprotein cholesterol (HDL-C) levels with an increased risk of lung cancer (10), and a prospective cohort study of Chinese men showed that low levels of low-density lipoprotein cholesterol (LDL-C) are implicated in an increased risk of lung cancer (11). Several recent studies have con rmed that dyslipidemia is associated with an increased risk of tumor recurrence and reduced survival for multiple cancer types (7,12,13). Our previous study found that preoperative lipid distribution has an important impact on the prognosis of patients with lung squamous cell carcinoma (7), but there is little evidence about the effect of lipid pro les on prognosis of patients with LUAD.…”