Nutritional Determinants of the Metabolic Syndrome

Josse, Andrea R.; Jenkins, David; Kendall, Cyril W.C.

doi:10.1159/000112458

Cited by 6 publications

(4 citation statements)

References 140 publications

(120 reference statements)

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“…The use of supplements was controlled for the potential impact of the dietary supplement on vitamin K intake and status. The final multivariate model included additional dietary factors such as intakes of fiber, total fat, polyunsaturated fat, saturated fat, total carbohydrate, and total energy, which have been shown to be related to MetS as reviewed by Josse [21]. For each logistic regression model, a separate analysis was carried out, excluding subjects who had taken supplements during the past month.…”

Section: Discussionmentioning

confidence: 99%

Dietary Phylloquinone Intakes and Metabolic Syndrome in US Young Adults

Pan

Jackson

2009

Journal of the American College of Nutrition

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Mean reported dietary phylloquinone intakes suggested that most US young adults consume an insufficient amount of vitamin K from their diet. A high intake of phylloquinone may favorably affect MetS or its components, probably through an overall more heart-healthy dietary pattern. The pathogenesis of MetS is profoundly complex and may involve other factors and/or mechanisms, in addition to vitamin K nutriture. Although our data suggest a potential role of vitamin K in MetS, the biological mechanisms underlying the observed associations must be elucidated.

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Section: Discussionmentioning

confidence: 99%

Dietary Phylloquinone Intakes and Metabolic Syndrome in US Young Adults

Pan

Jackson

2009

Journal of the American College of Nutrition

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“…Known risk factors for metabolic syndrome include age, obesity, diet, dietary patterns across life stages, and lack of exercise with variation in the prevalence observed across gender and ethnic groups (Park et al, 2003; Josse et al, 2008; Otsuka et al, 2010; Li et al, 2011; Beltran-Sanchez et al, 2013). Current smoking has been associated with the presence of insulin resistance, diabetes and metabolic syndrome (Facchini et al, 1992; Will et al, 2001; Park et al, 2003; Weitzman et al, 2005) whereas alcohol consumption appears to be protective to some extent (Liu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome is associated with exposure to organochlorine pesticides in Anniston, AL, United States

Rosenbaum

Weinstock

Silverstone

et al. 2017

Environment International

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The Anniston Community Health Survey, a cross-sectional study, was undertaken in 2005–2007 to study environmental exposure to polychlorinated biphenyl (PCB) and organochlorine (OC) pesticides and health outcomes among residents of Anniston, AL, United States. The examination of potential risks between these pollutants and metabolic syndrome, a cluster of cardiovascular risk factors (i.e., hypertension, central obesity, dyslipidemia and dysglycemia) was the focus of this analysis. Participants were 548 adults who completed the survey and a clinic visit, were free of diabetes, and had a serum sample for clinical laboratory parameters as well as PCB and OC pesticide concentrations. Associations between summed concentrations of 35 PCB congeners and 9 individual pesticides and metabolic syndrome were examined using generalized linear modeling and logistic regression; odds ratios (OR) and 95% confidence intervals (CI) are reported. Pollutants were evaluated as quintiles and as log transformations of continuous serum concentrations. Participants were mostly female (68%) with a mean age (SD) of 53.6 (16.2) years. The racial distribution was 56% white and 44% African American; 49% met the criteria for metabolic syndrome. In unadjusted logistic regression, statistically significant and positive associations across the majority of quintiles were noted for seven individually modeled pesticides (p,p′-DDT, p,p′-DDE, HCB, β-HCCH, oxychlor, tNONA, Mirex). Following adjustment for covariables (i.e., age, sex, race, education, marital status, current smoking, alcohol consumption, positive family history of diabetes or cardiovascular disease, liver disease, BMI), significant elevations in risk were noted for p,p′-DDT across multiple quintiles (range of ORs 1.61 to 2.36), for tNONA (range of ORs 1.62–2.80) and for p,p′-DDE [OR (95% CI)] of 2.73 (1.09–6.88) in the highest quintile relative to the first. Significant trends were observed in adjusted logistic models for log10 HCB [OR = 6.15 (1.66–22.88)], log10 oxychlor [OR = 2.09 (1.07–4.07)] and log10 tNONA [3.19 (1.45–7.00)]. Summed PCB concentrations were significantly and positively associated with metabolic syndrome only in unadjusted models; adjustment resulted in attenuation of the ORs in both the quintile and log-transformed models. In conclusion, several OC pesticides were found to have significant associations with metabolic syndrome in the Anniston study population while no association was observed for PCBs.

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“…Studies have demonstrated the benefits to patients with metabolism-related disorders of restricted dietary calories (Azadbakht, Mirmiran, Esmaillzadeh, Azizi, & Azizi, 2005;Josse, Jenkins, & Kendall, 2008;Konig, Deibert, Frey, Landmann, & Berg, 2008) and increased intake of certain macronutrients (Flachs, Rossmeisl, & Kopecky, 2014;Gadgil et al, 2013;Rizza et al, 2009), particularly n-3 longchain polyunsaturated fatty acids (LC-PUFA). de Mello et al (2011) reported that MetS patients who consumed a healthy diet that included fatty fish and wholegrain products for 12 weeks had reduced levels of markers of inflammation and endothelial dysfunction, such as plasma E-selectin and highsensitivity C-reactive protein (hsCRP) (de Mello et al, 2011;Su, Lee, Cheng, & Huang, 2014).…”

Section: Introductionmentioning

confidence: 99%