Distiller's Dried Grains with Solubles (DDGS) as untraditional feedstuff has been available for feed industry for many years and became a nutritional and economical feed ingredient. According to recent studies, DDGS is usually used at low concentrations (10 or 15%) as a feed ingredient in laying hen diets without adverse effects on laying performance, feed utilization, nutrient digestibility, egg quality criteria and economics. Because DDGS became available in feed market in large amounts, the ability of using higher DDGS inclusion rate in poultry feed has become an interest for several researchers and poultry producers. Using such untraditional feedstuffs aims mainly to decrease the feed costs. Researchers assured that feeding higher levels of DDGS could have a significant effect on the cost of feed for poultry producers because of higher availability of DDGS and the current price fluctuations of feed ingredients. On the other hand, beneficial effects of DDGS on the environment have also been reported. These beneficial effects could be represented through mitigating harmful emissions and pollution from manure which provides production within clean atmosphere. Findings from different researches on the use of DDGS as feed ingredient for laying hens are illustrated in this review. Moreover, this study describes advanced information regarding the use of corn DDGS as untraditional feedstuff for laying hens involving its production process and nutritive value along with its useful effects on laying hens production traits, egg quality, apparent digestibility, economics and the impact on the surrounding environment in poultry house.