Nutritional habits and oxidative stress in postmenopausal age

Grygiel-Górniak, Bogna; Justyna, M; Szczepanik, Adam; Przysławski, Juliusz

doi:10.20452/pamw.2293

Cited by 15 publications

(14 citation statements)

References 21 publications

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“…4,31 In women, the rise in obesity with age may be related to hormonal changes, 44 and in men in the older age categories, body mass may be associated with muscle atrophy or may be a result of the attempts to correct earlier nutritional habits. 4, 45 The prevalence of obesity may differ across subpopulations within countries, which may be associated with regional differences in socioeconomic factors related to obesity.…”

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confidence: 99%

Prevalence of general and abdominal obesity and overweight among adults in Poland. Results of the WOBASZ II study (2013–2014) and comparison with the WOBASZ study (2003–2005)

Stepaniak¹,

Micek²,

Waśkiewicz³

et al. 2016

Polish Archives of Internal Medicine

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confidence: 99%

Prevalence of general and abdominal obesity and overweight among adults in Poland. Results of the WOBASZ II study (2013–2014) and comparison with the WOBASZ study (2003–2005)

Stepaniak¹,

Micek²,

Waśkiewicz³

et al. 2016

Polish Archives of Internal Medicine

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“…[1][2][3][4] With aging, a greater incidence of HTN and cardiovascular complications is widely observed in postmenopausal women compared with premenopausal women. 5,6 The hypertensive state is often associated with dyslipidemia, 7 obesity (nearly 40% of hypertensive patients are obese), 8 and IR.…”

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confidence: 99%

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Grygiel-Górniak

Kaczmarek

Mosor

et al. 2015

J of Clinical Hypertension

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The aim of this study was to test the association of peroxisome proliferator-activated receptor (PPAR-c2) (Pro12Ala, C1431T) and b3-AR (Trp64Arg) polymorphisms with metabolic, nutritional, and blood pressure parameters in 271 postmenopausal women (151 hypertensive and 120 normotensive controls). The TaqMan genotyping assay and restriction fragment length polymorphism methods were used to determine the distributions of selected alleles and genotype frequencies. Nutritional status was determined by a bioimpedance method and dietary habits were assessed via 7-day dietary recall. The distribution of selected genotypes and allele frequencies did not differ between hypertensive women and normal controls after analysis by chi-square test. The postmenopausal hypertensive women were older and had higher body fat mass, serum glucose, and triglyceride levels. The cluster analysis showed that the hypertensive group with Pro12Pro genotype had highest pulse pressure and mean arterial pressure values when compared with Pro12Ala patients. In the logistic regression analysis, blood glucose (Pro12Ala polymorphism) and energy intake (C1431Tand T1431T polymorphisms) determined hypertension. J Clin Hypertens (Greenwich). 2015;17:549-556. ª 2015 Wiley Periodicals, Inc.Increased body weight, insulin resistance (IR), hyperglycemia, abnormal blood lipid profiles, oxidative stress, and hypertension (HTN) contribute to cardiovascular diseases.1-4 With aging, a greater incidence of HTN and cardiovascular complications is widely observed in postmenopausal women compared with premenopausal women. 5,6 The hypertensive state is often associated with dyslipidemia, 7 obesity (nearly 40% of hypertensive patients are obese), 8 and IR. 9 Moreover, blood pressure (BP) in women presents specific hemodynamic characteristics, and, in the postmenopausal age, the role of pulse pressure (PP) predominates over that of mean arterial pressure (MAP) in the mechanism of high BP. The stiffness of the large elastic arteries in cardiothoracic (central) circulation increases with age 10 and it results in progressive age-associated elevations in SBP and PP. These changes accelerate after the age of 50 and are much greater in women than in men. 5,6 Studies have shown that PPAR-c2 polymorphisms (Pro12Ala, C14131T) and b-adrenergic receptor gene polymorphisms (b3-AR Trp64Arg) may have an important impact on adipose tissue, 11 metabolic parameters, 12,13 and inflammation in the vasculature, and through their influence determine high BP.14,15 Some data have indicated that Pro12Pro normoglycemic homozygotes had significantly higher incidence of HTN 16 and higher diastolic BP (DBP) 17 when compared with Ala12 carriers. However, the association between the Pro12Ala variants and arterial BP remains controversial and most other studies could not demonstrate such an association, 18,19 while some even indicated that Ala12 carriers had higher BP. 20 Besides this, the polymorphisms have been mostly studied separately (not in constellation) in patients with diabetes mellitus or o...

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“…RBCs involved in the transportation of oxygen, white blood cells play role against certain pathogens, platelets play role in blood clotting. 19 It is suggested that low levels of blood cells were found in this bone disorder which accounts for more complexities, thus making the body weaker day by day. The Hb level is also reduced from their normal value which shows the occurrence of anemia.…”

Section: Discussionmentioning

confidence: 98%

Vitamin-D Deficiency; Assessment of Potential Risk Factor and Antioxidative Status in Vitamin-D Deficient Females

Malik¹,

Shaheen²,

Farooq³

et al. 2017

TPMJ

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ABSTRACT… Background: Deficiency of vitamin D is characterized by the low bone mass which leads to the bone fragility and high risk of fractures. Bone fractures causes the formation of free radicals, generated by the tissue damaged. Uncontrolled production of free radicals accelerates the oxidative stress and increased the bone remodeling process ultimately causes osteoporosis. One of the most damaging effects of free radicals is lipid peroxidation; end product of which is MDA, it also act as major factor in osteoblastic activity. Low level of antioxidative defense system found in osteoporotic patients due to the deficiency of vitamin D. Many important mineral ions removed from bones and risk of bone fragility increases. Current study is aim to check the antioxidative effect produced from excess reactive oxygen species compared with low level of vitamin D which is held responsible for higher or lower activity of bone cells. Study Design: Case Control Study. Setting: Study was conducted at Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore. Period of Study: One year. Materials and Methods: Blood samples of 272 post-menopausal osteoporotic women between the age 49-57 were collected from Jinnah hospital Lahore. While the samples of 92 individuals were served as a control. Concentration of both enzymatic and non-enzymatic antioxidant such as CAT, GSH, SOD, GPx and GR, vitamin A, C and E and levels of MDA were estimated spectrophotometrically. While the concentration of IL6, AOPPS, AGEs, TNF-α, MMP9, Isoprostanes, LDH, cholesterol, triglycerides, free fatty acids and phospholipid were measured by using commercially available Elisa kits. Results: Blood plasma levels of vitamin D were significantly lower in osteoporosis patients than in normal subjects. In addition, level of stress biomarker such as MDA was found to be higher in patients as compared to control. Due to oxidative stress, level of antioxidants (GSH, CAT, and SOD) was found to be reduced. Blood cells and many other important minerals are also reduces in patient group from their normal amount. Conclusion: It concludes that excess production of free radicals over whelms the antioxidative system, thus it may leads to osteoporosis. Further more antioxidant species subjected to body might protect bone loss and also help in acceleration of healing of fractured bones. Key words:Osteoporosis, vitamin D, CAT, GSH, SOD, GPx and GR, MDA.

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Nutritional habits and oxidative stress in postmenopausal age

Cited by 15 publications

References 21 publications

Prevalence of general and abdominal obesity and overweight among adults in Poland. Results of the WOBASZ II study (2013–2014) and comparison with the WOBASZ study (2003–2005)

Prevalence of general and abdominal obesity and overweight among adults in Poland. Results of the WOBASZ II study (2013–2014) and comparison with the WOBASZ study (2003–2005)

Association of PPAR‐γ2 and β3‐AR Polymorphisms With Postmenopausal Hypertension

Vitamin-D Deficiency; Assessment of Potential Risk Factor and Antioxidative Status in Vitamin-D Deficient Females

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