Nutritional influence on epigenetics and effects on longevity

Niculescu, Mihai D.; Lupu, Daniel S.

doi:10.1097/mco.0b013e328340ff7c

Cited by 44 publications

(25 citation statements)

References 48 publications

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“…Epigenetic modifications can modify hundreds or thousands of genes, so targeting a given epigenetic protein or modification may be a more powerful approach, although much work remains for this strategy to be feasible. Therefore, the case for an epigenetic link between nutrition and longevity is strong, even if the specific epigenetic role of nutrients in modulating aging remains unknown (Niculescu and Lupu, 2011).…”

Section: Future Prospects In Epigenetics and Agingmentioning

confidence: 99%

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

et al. 2011

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Section: Future Prospects In Epigenetics and Agingmentioning

confidence: 99%

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

et al. 2011

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“…In the same way, during aging, some genes may be aberrantly expressed due to altered epigenetic marks [98]. At this stage, knowledge in this area is confined to proof-of-principle studies in animal models and very few and limited human studies [53,99]. As a consequence, new knowledge gaps have been identified, with new research priorities such as the study of the variation of individual nutritional requirements brought on by epigenetics, lifestyle, environment, and geography [[78], p. 170] during the course of a lifetime; the development of biomarkers of disease risk and interventions aiming to prevent or reverse the adverse effects of a poor early-life environment [47,53], and the identification of genes and pathways which are likely to be regulated epigenetically during aging and where effects of aging may be modulated by nutrition [98].…”

Section: Discussionmentioning

confidence: 99%

Inclusion and Exclusion in Nutrigenetics Clinical Research: Ethical and Scientific Challenges

Hurlimann

Stenne²,

Menuz³

et al. 2011

Lifestyle Genomics

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Background/Aims: There are compelling reasons to ensure the participation of ethnic minorities and populations of all ages worldwide in nutrigenetics clinical research. If findings in such research are valid for some individuals, groups, or communities, and not for others, then ethical questions of justice – and not only issues of methodology and external validity – arise. This paper aims to examine inclusion in nutrigenetics clinical research and its scientific and ethical challenges. Methods: In total, 173 publications were identified through a systematic review of clinical studies in nutrigenetics published between 1998 and 2007. Data such as participants’ demographics as well as eligibility criteria were extracted. Results: There is no consistency in the way participants’ origins (ancestry, ethnicity, or race) and ages are described in publications. A vast majority of the studies identified was conducted in North America and Europe and focused on ‘white’ participants. Our results show that pregnant women (and fetuses), minors, and the elderly (≧75 years old) remain underrepresented. Conclusion: Representativeness in nutrigenetics research is a challenging ethical and scientific issue. Yet, if nutrigenetics is to benefit whole populations and be used in public and global health agendas, fair representation as well as clear descriptions of participants in publications are crucial.

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“…In fact, some histone deacetylases, like sirtuins, are known to modify epigenetic patterns 29 . Notably, while the epigenetic role of nutrients in the modulation of ageing remains unknown, there is a strong epigenetic link between nutrition and longevity 43 . It is noteworthy that ageing and longevity is at least in part governed by epigenetic mechanisms and an increased understanding of all ageingrelated events that are driven by these mechanisms will allow for the development of novel epigeneticbased diagnostic, preventive and therapeutic strategies for ageing and agerelated diseases in the near future.…”

Section: Role Of Epigenetics In Human Ageing and Longevitymentioning

confidence: 99%

Genetic and Environmental Contributions to Human Longevity

Awofala¹,

Ogundele²

2016

Arşiv Kaynak Tarama Dergisi

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Human longevity, like most complex phenotypes, is thought to reflect a complex interplay of both environmental (e.g. lifestyle choices, where we live in) and genetic factors. These factors are likely to influence the basic mechanism of ageing and in turn broadly influence susceptibility to agerelated illness. Thus, good lifestyle choices and conducive environment coupled with lack of genetic variants that predispose to diseases as well as having variants that confer resistance to diseases are probably vital to achieving old age. Although, the scientific understanding of the mechanism governing longevity is still sparse, understanding its biological underpinnings, including the potential contribution of genes and environment, is a key for shaping individual's lifestyle choices and developing efficacious therapeutic targets to increase lifespan. This review provides an overview of different strategies that are being integrated increasingly to extend our knowledge of the genetic and environmental underpinnings of human longevity.

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Nutritional influence on epigenetics and effects on longevity

Abstract: Complex epigenetic mechanisms are involved in aging and longevity, directly or indirectly via disease mechanisms. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promise in having important roles in regulating longevity and aging.

Cited by 44 publications

References 48 publications

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery

Inclusion and Exclusion in Nutrigenetics Clinical Research: Ethical and Scientific Challenges

Genetic and Environmental Contributions to Human Longevity

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