Nutritional management of gastric ulceration

Andrews, Frank M.; Larson, C. K.; Harris, Pat

doi:10.1111/eve.12495

Cited by 25 publications

(25 citation statements)

References 91 publications

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“…Omeprazole is absorbed in the duodenum and it has recently been suggested that the drug should be administered on an empty stomach . On the other hand, it has also been recommended that keeping the stomach permanently full with forage, feeding forage ad libitum may be beneficial in gastric disease .…”

Section: Discussionmentioning

confidence: 99%

Chronic severe pyloric lesions in horses: 47 cases

Bezděková¹,

Wohlsein²,

Venner³

2019

Equine Veterinary Journal

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Summary Background The clinical findings and outcome associated with chronic severe equine pyloric lesions have not been well described previously. Objectives To describe the history, clinical signs, endoscopic and ultrasound results, laboratory data, treatment, pathological findings and survival of horses with chronic severe pyloric lesions. Study design Retrospective case series. Methods Medical records from horses treated at clinics in Czech Republic and Germany in which chronic severe pyloric lesions were confirmed endoscopically and/or on post‐mortem examination were reviewed. Results Forty‐seven horses were identified, median age 3 years (range 0.8–16 years). There were 3 geldings, 23 mares and 19 stallions and the majority were Warmbloods (60%). The most common presenting signs were poor body condition (40; 87%), slow eating (39; 83%), recurrent colic (35; 74%) and selective appetite (30; 64%). The most consistent laboratory abnormality was hypoalbuminaemia (10; 36%). Slow gastric emptying was confirmed in 29 individuals during gastroscopy and/or ultrasonography. Endoscopy revealed distal oesophagitis in 9 of 47 horses, and severe equine squamous gastric disease in all cases. Pyloric lesions were depressed, flat or raised fibrinosuppurative pyloric ulcers and were seen in 45 (2 pylori were not seen endoscopically). Thirty‐two cases were treated, with 28 responding well initially. All treated cases received anti‐ulcer medication and four underwent gastrojejunostomy. Clinical signs recurred after medical treatment in at least 11 cases. Only 18 of 44 cases (41%) survived long term (3 were lost to follow‐up). Horses diagnosed at 3 years of age or younger were significantly less likely to survive more than 6 months than older horses (27.8% vs. 72.2%, P<0.001). Main limitations The study is retrospective, some records were incomplete and case identification was subjective. Conclusions Chronic severe pyloric lesions can be associated with delayed gastric emptying identified with ultrasonography and/or endoscopy. The prognosis is poor in young horses.

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Section: Discussionmentioning

confidence: 99%

Chronic severe pyloric lesions in horses: 47 cases

Bezděková¹,

Wohlsein²,

Venner³

2019

Equine Veterinary Journal

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“…Clearly there is a role of nutrition in induction and maintenance of squamous gastric ulcers (Andrews et al 2015). In general, for prevention of EGUS/EGSD, a minimum dry matter (DM) intake of ≥ 1.5 % -2 % BW (body weight) (Andrews et al 2015, Harris et al 2017) with an absolute minimum recommendation of 1.25 % DM intake of BW (Har-ris et al 2017) and avoiding long periods of fasting are recommended Coenen 2004, Andrews et al 2015). High forage diets increase chewing activity which is linked to the production of more saliva (Nadeau and Andrews 2009).…”

Section: Introductionmentioning

confidence: 99%

“…High forage diets increase chewing activity which is linked to the production of more saliva (Nadeau and Andrews 2009). However little evidence exists for the exact role of diet (Andrews et al 2015 as well as for the nutritional management in glandular gastric disease (Andrews et al 2015. Nevertheless, it has been suggested that diet might influence the risk for EGGD in a manner similar to EGUS and that the principles for feeding might be the same for horses with squamous and/or glandular disease (Andrews et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses

Bäuerlein¹,

Sabban²,

Venner³

et al. 2020

PHK

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Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses V. Bäuerlein et al. Pferdeheilkunde -Equine MedicineSummary: Equine gastric ulcer syndrome (EGUS) is a common health problem in horses and foals. Beside the importance of forage feeding for the gastric mucosa, results of studies targeting the specific effect of alfalfa on different gastric mucosal regions are controversial. The objectives of this study were to determine the influence of the two forage types (1) meadow hay and (2) alfalfa hay with similar fiber length on different gastric mucosal regions in order to further clarify the effect of alfalfa hay on the equine gastric mucosa. It was hypothesized that feeding alfalfa hay will impair mucosal integrity of the pylorus and antrum pyloricum but may be a benefit for the squamous regions. In a randomized blinded prospective study with a cross-over design, 10 healthy adult warmblood horses were separated randomly into two groups each with five horses. Both groups were fed with 2 kg/100 kg BW/animal/day alfalfa hay or meadow hay in two feeding periods each 21 days long. A wash out period of 21 days was conducted between the feeding periods. Before and after feeding periods body condition score (BCS), body weight (BW), clinical health status, feces pH and particle size and gastroscopic findings were determined. Each region of the gastric mucosa was assessed and scored separately. Data such as BW, fecal pH and fecal particle size were analyzed for normal distribution by the Shapiro-Wilks test. BCS, gastroscopic findings and fecal pH were subjected to non-parametric statistical tests. Kruskal-Wallis ANOVA and Wilcoxon test were performed to compare the findings in gastric mucosal scores, BCS and fecal pH. The relative change in BW and fecal particle size were analyzed by one-factorial analysis of variance (ANOVA). Data are presented as medians, 25th and 75th percentiles. Relative BW changes and fecal particle size are given as means ± standard deviation (SD). Statistical significance was set at p < 0.05. Before starting the feeding trial, the prevalence of overall gastric mucosal lesions was 100 % with a median severity score of 1. After the feeding period, the median lesion score of the lesser curvature of the squamous region decreased significantly from a median of 1 to a median of 0 in the alfalfa group. The median score of 0 remained constant before and after feeding the meadow hay. Findings in the pyloric region did not differ significantly between the two feeding groups. We concluded that feeding alfalfa hay seems to have no detrimental effects on the mucosal integrity at the squamous gastric region in healthy adult horses. With respect to the glandular area, feeding alfalfa hay appears to be noncritical in healthy adult horses. Further studies are needed to investigate the effects of feeding alfalfa hay in horses suffering from severe mucosal lesions at the antrum pyloricum or pylorus. Furthermore, the longer fecal particle size in horses fed alfalfa hay...

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“…It is however, well established that chronic use of NSAIDs predisposes to the gastric ulcer Hydrochloric acid is primarily responsible for the ulcers in the distal oesophagus and nonglandular region of the stomach; while breakdown in the mucosal defence mechanisms is responsible for the ulcers in the glandular stomach and proximal duodenum. 6 In ZES, a gastrin secreting tumor of the pancreas stimulates the parietal cells in stomach to increase the acidity, resulting in gastrointestinal mucosal ulceration. This ulcer is refractory to proton pump inhibitor therapy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

Suleiman¹,

.²,

Mikail³

et al. 2019

TJNPR

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Article history:preliminary evaluation of crude methanol stem-bark extract of the plant revealed potent antiulcer properties. 21 Although much progress has been made in the management of H. pylori infection in gastric ulcer due to the widespread use of antisecretory drugs and antibiotics, increasing antimicrobial resistance has posed a great threat to its eradication. 22 Furthermore, emerging causes of peptic ulcers other than H. pylori and NSAIDs are imposing diagnostic and therapeutic challenges. Therefore, the aim of this study was to investigate the anti-ulcer effects of the stem-bark fractions of K. senegalensis in rats.

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Nutritional management of gastric ulceration

Cited by 25 publications

References 91 publications

Chronic severe pyloric lesions in horses: 47 cases

Chronic severe pyloric lesions in horses: 47 cases

Effects of feeding alfalfa hay in comparison to meadow hay on the gastric mucosa in adult Warmblood horses

Evaluation of Anti-Ulcer Properties of the Stem-Bark Fractions of Khaya senegalensis (Desr.) A. Jussin Albino Rats

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