Nutritional predictors of postoperative outcome in pancreatic cancer

Kanda, Mitsuro; Fujii, Tsutomu; Kodera, Yasuhiro; Nagai, Shunji; Takeda, Shin; Nakao, Akimasa

doi:10.1002/bjs.7305

Cited by 539 publications

(410 citation statements)

References 36 publications

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“…Recent studies have reported the prognostic significance of the preoperative inflammation-based scores, such as the GPS, the neutrophil to lymphocyte ratio (23), the platelet to lymphocyte ratio (24), the Prognostic index (25), and the Prognostic nutritional index (26). An inflammatory response to the tumor leads to tumor proliferation and metastasis due to inhibition of apoptosis and promotion of angiogenesis (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Shiba¹,

Horiuchi²,

Sakamoto³

et al. 2017

Oncology Letters

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Abstract. Systemic inflammation, as evidenced by the Glasgow prognostic score (GPS), predicts cancer-specific survival in various cancer types. The aim of this study was to evaluate the significance of the GPS in the therapeutic outcome of the patient following surgical resection for hepatocellular carcinoma. In total, 144 patients underwent surgical resection for hepatocellular carcinoma. For the assessment of systemic inflammatory response using the GPS, patients were classified into three groups: Patients with normal serum albumin (<3.5 g/dl) and normal serum C-reactive protein (CRP) (≤1.0 mg/dl) were classified as GPS 0 (n=76), those with low serum albumin (<3.5 g/dl) or elevated serum CRP (>1.0 mg/dl) were classified as GPS 1 (n=58), and those with low serum albumin (<3.5 g/dl) and elevated serum CRP (>1.0 mg/dl) were classified as GPS 2 (n=10). Retrospectively, the relationship between patient characteristics including GPS, disease-free as well as overall survival were investigated. In disease-free survival, GPS 2 (P=0.019), with a tumor number ≥3 (P=0.004), and positive portal or venous invasion (P= 0.034) were independent predictors of cancer recurrence in multivariate analysis. In overall survival, GPS 1 (P= 0.042), GPS 2 (P<0.001) and positive portal or venous invasion (P<0.001) were independent predictors of poor patient outcome according to multivariate analysis. To conclude, the GPS in patients with hepatocellular carcinoma is an independent prognostic predictor after hepatic resection.

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Section: Discussionmentioning

confidence: 99%

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Shiba¹,

Horiuchi²,

Sakamoto³

et al. 2017

Oncology Letters

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“…Preoperative albumin levels and prognostic nutrition index (PNI) have been shown to be independent factors to predict POPF. Serum albumin level of < 4.0 g/dl and a PNI of < 45 is associated with significantly higher incidence of fistula (37.5 % versus 18.7 % and 40 % versus 22 % respectively) [37]. Patients with higher BMI (>25 kg/m 2 ) are associated with an increased risk of POPF [38,39].…”

Section: Patient Factorsmentioning

confidence: 96%

Pancreatoduodenectomy - Preventing Complications

Penumadu

Barreto

Goel

et al. 2014

Indian J Surg Oncol

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Increased awareness of periampullary & pancreatic head cancers, and the accompanying improved outcomes following pancreatoduodenectomy (PD), has possibly led to an increase in patients seeking treatment for the same. While there has definitely been a reduction in morbidity rates following PD in the last few decades, this decline has not mirrored the drastic fall in mortality. Amongst the foremost in the factors responsible for this reduction in mortality is the standardization of surgical technique and development of dedicated teams to manage all aspects of this demanding procedure. This review intends to provide the reader with an overview of major complications following this major surgery and measures to prevent them based on the authors' experience.

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“…There were also many studies reporting that haematological markers of systemic inflammatory response such as white blood cell count or its components (neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR)), platelet, and platelet-lymphocyte ratio (PLR) are also prognostic indicators for cancer clinical outcomes (Yamanaka et al, 2007;Cho et al, 2009;Kishi et al, 2009;Sarraf et al, 2009;Kwon et al, 2012;Dalpiaz et al, 2013;Fox et al, 2013). In addition, other inflammatory factor combinations such as Prognostic Index (PI) and Prognostic Nutritional Index (PNI) have also been linked with prognosis of malignancies (Kasymjanova et al, 2010;Nozoe et al, 2010;Kanda et al, 2011). However, the value of these markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic GC receiving first-line chemotherapy remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR , GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

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Nutritional predictors of postoperative outcome in pancreatic cancer

Abstract: The PNI is associated with overall survival and postoperative complications, in particular pancreatic fistula, in patients with pancreatic cancer. The moderate accuracy of PNI as a predictor of survival limits its clinical use.

Cited by 539 publications

References 36 publications

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Pancreatoduodenectomy - Preventing Complications

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

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