Nutritional Recommendations for Diabetic Patients and Treatment with α-Glucosidase Inhibitors

Rare sugar d-allulose: Potential role and therapeutic monitoring in maintaining obesity and type 2 diabetes mellitus

“…4. It has been proven that strict glycemic control is associated with a low incidence of both micro-and macro-vascular complications in diabetes, and a delay or inhibition of carbohydrate digestion could be helpful in avoiding postprandial hyperglycemia (Toeller, 1992). Specific inhibitors of -glucosidase have exhibited a definite therapeutic value in suppressing the postprandial glycemic increase by delaying carbohydrate digestion (Puls et al, 1977).…”

“…Although a definite therapeutic value of other known -glucosidase inhibitors in diabetic patients has been demonstrated, unpleasant side effects associated with incomplete absorption of dietary carbohydrates, such as flatulence, abdominal discomfort, and diarrhea (Toeller, 1992), have been reported. These side effects may be due to the potent inhibition of pancreatic amylases and many intestinal enzymes, which in turn strongly inhibit the digestion of both sucrose and starch.…”

No Relationship Between Carbohydrate Intake and Effect of Acarbose on HbA1c or Gastrointestinal Symptoms in Type 2 Diabetic Subjects Consuming 30–60% of Energy From Carbohydrate

“…In addition, acarbose does not influence the absorption of monosaccharides, such as glucose and fructose (2). For these reasons, it has been suggested that to obtain the greatest benefit from acarbose therapy, individuals with diabetes should maintain a diet high in complex carbohydrates and low in simple sugars (3). This suggestion was supported recently by Hara et al (4) who reported that 6 months of acarbose therapy had no effect on blood glucose control in individuals consuming <50% of energy from carbohydrates, but it reduced HbA lc from >8 to 6.5% in those consuming >50% carbohydrate.…”

Kardiovaskul�re Effekte oraler Antidiabetika

“…Voraussetzung für die effektive Wirkung der Substanzen ist naturgemäß ihre Einnahme mit dem ersten Bissen der Hauptmahlzeit sowie eine Ernährungsweise mit Betonung komplexer Kohlenhydrate oder wenigstens von Disacchariden, da bei Zufuhr von Monosacchariden die α-Glucosidaseinhibitoren wirkungslos sind [44].…”