Nutritional Status and Bone Microarchitecture in a Cohort of Systemic Sclerosis Patients

Paolino, Sabrina; Pacini, G.; Schenone, C.; Patanè, Massimo; Sulli, Alberto; Sukkar, Samir Giuseppe; Lercara, Adriano; Pizzorni, Carmen; Gotelli, Emanuele; Cattelan, F.; Goegan, Federica; Smith, Vanessa; Cutolo, Maurizio

doi:10.3390/nu12061632

Cited by 14 publications

(13 citation statements)

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“…Some studies have focused on statistically significant relationships between vitamin D and parathyroid hormone (PTH), not only in healthy individuals but also in SSc patients [ 12 , 13 , 31 , 35 , 46 ]. Furthermore, Hax et al demonstrated that 25-hydroxyvitamin D [25(OH)D] levels are inversely correlated with PTH [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Hax et al demonstrated that 25-hydroxyvitamin D [25(OH)D] levels are inversely correlated with PTH [ 12 ]. Paolino et al identified significant differences in malnourished SSc patients in the median values of PTH and vitamin D levels [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hypovitaminosis D is a general finding in scleroderma [ 3 – 5 , 9 , 10 , 13 , 15 , 16 , 21 , 25 , 27 , 34 , 35 ], and based on its pleiotropic effects, including its immunomodulatory, cardioprotective, and antifibrotic properties, low vitamin D status could influence the pathogenetic pathways activated in SSc [ 30 ]. Nevertheless, the association between abnormal vitamin D status and SSc onset, or any of its clinical manifestations, is still under debate [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review

Diaconu

Ostafie

Ceasovschih

et al. 2021

Journal of Immunology Research

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Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant immunity. Vitamin D is a steroid hormone with pleiotropic effects beyond its traditional role in calcium and bone homeostasis. Since vitamin D has immunomodulatory, cardioprotective, and antifibrotic properties, it could potentially interfere with SSc pathogenesis. Suboptimal vitamin D levels are classically recognized in scleroderma, irrespective of clinical and serological phenotype. Aim. This systematic review is aimed at investigating and clarifying the role of vitamin D in SSc and emphasizing the association of vitamin D status with different clinical settings. Methods and Results. A systematic online search was performed, using PubMed databases to collect articles on the topic of vitamin D in SSc. The final analysis included 40 eligible articles. Conclusions. Hypovitaminosis D is common in SSc patients and could be associated with clinical and serologic patterns of the disease. Intervention for low serum vitamin D levels in SSc pathogenesis remains controversial, as well as the significance of vitamin D supplementation in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review

Diaconu

Ostafie

Ceasovschih

et al. 2021

Journal of Immunology Research

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“…These changes could be associated with less epigastric pain. However, this could have contributed to the reduction the symptoms even in the NCS-f diet group because suboptimal body composition is associated with more gastrointestinal symptoms [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial

et al. 2022

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Background: A diet containing non-caloric sweeteners (NCS) could reduce calorie intake; conversely, some animal studies suggest that NCS consumption may increase functional gastrointestinal disorder symptoms (FGDs). This study aimed to compare the effect of consuming a diet containing NCS (c-NCS) versus a non-caloric sweetener-free diet (NCS-f) on FGDs. Methods: We conducted a randomized, controlled, parallel-group study using two different diets for five weeks: the c-NCS diet contained 50–100 mg/day NCS, whereas the NCS-f diet had less than 10 mg/day NCS. At the beginning of the study (PreTx) and at the end (PostTx), we assessed FGDs, dietary intake, and NCS consumption. Results: The percentage of participants with diarrhea (PreTx = 19% vs. PstTx = 56%; p = 0.02), post-prandial discomfort (PreTx = 9% vs. PstTx = 39%; p = 0.02), constipation (PreTx = 30% vs. PostTx = 56%; p < 0.01), and burning (PreTx = 13% vs. PostTx = 33%; p < 0.01) increased in the c-NCS diet group. Conversely, abdominal pain (PreTx = 15% vs. PostTx = 3%; p = 0.04), post-prandial discomfort (PreTx = 26% vs. PostTx = 6%; p = 0.02), burning (PreTx = 15% vs. PostTx = 0%; p = 0.02), early satiety (PreTx = 18% vs. PostTx = 3%; p < 0.01), and epigastric pain (PreTx = 38% vs. PostTx = 3%; p < 0.01) decreased in the NCS-f diet group. Conclusion: A c-NCS diet is associated with increased FGDs, including diarrhea, post-prandial discomfort, constipation, and burning or retrosternal pain. The NCS-f diet also decreased FGDs, as well as abdominal pain, post-prandial discomfort, burning or retrosternal pain, early satiety, and epigastric pain.

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“…A further study by Paolino et al investigated the impact of gastrointestinal (GI) involvement on bone microarchitecture in systemic sclerosis (SSc). GI involvement in SSc is characterised by the atrophy of the smooth muscle and small bowel hypomotility, overall coming from autonomic nerve dysfunction [9]. These alterations significantly affect gut transit and nutrient absorption, culminating in nutritional deficits induced by malabsorption that consequently also led to bone alterations.…”

mentioning

confidence: 99%