Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico

Camacho, María Esther Irigoyen; Pérez, Álvaro García; González, Andrea; Huízar-Álvarez, Rafael

doi:10.1016/j.scitotenv.2015.09.085

Cited by 48 publications

(20 citation statements)

References 43 publications

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“…Furthermore in a study by Irigoyen et al . [28] in Mexico, association between malnutrition and defects in the enamel were observed in an area where the water contained 2.7 mg/L of fluoride. Similarly Pérez-Pérez et al .…”

Section: Discussionmentioning

confidence: 99%

Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Carmen

Javier

Aline

2016

J Int Soc Prevent Communit Dent

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Objective:The aim of this study was to assess urine fluoride concentration, nutritional status, and dental fluorosis in adolescent students living in the rural areas of Guanajuato, Mexico.Materials and Methods:A cross-sectional study was conducted including participants aged 11–20 years. The presence and severity of dental fluorosis was registered according to the Thylstrup and Fejerskov index (TFI) criteria. Anthropometric measures were also recorded. Urine sample of the first morning spot was recollected to assess urine fluoride concentration by using the potentiometric method with an ion-selective electrode. Water samples were also recollected and analyzed. Bivariate tests were performed to compare urine fluoride concentration according to different variables such as sex, body mass index, and TFI. Nonparametric tests were used. A logistic regression model was performed (SPSS® 21.0).Results:This study included 307 participants with a mean age of 15.6 ± 1.6; 62.5% of the participants showed normal weight. A total of 91.9% of the participants had dental fluorosis, and 61.6% had TFI > 4. Mean fluoride content in urine ranged between 0.5 and 6.65 mg/L, with a mean of 1.27 ± 1.2 mg/L. Underweight children showed greater urine fluoride concentration. The increment of urine fluoride was a related (OR = 1.40) to having severe dental fluorosis.Conclusions:Most of the studied population had moderate or severe dental fluorosis. Urine fluoride concentration was related to fluorosis severity and nutritional status. Underweight children showed greater urine fluoride concentration as well as severe dental fluorosis.

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Section: Discussionmentioning

confidence: 99%

Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Carmen

Javier

Aline

2016

J Int Soc Prevent Communit Dent

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“…High levels of fluoride have been found in groundwater of more than twenty developed and developing countries, including China [ 4 , 5 ]. It has been demonstrated that excessive ingestion of fluoride can results in structural and functional changes in teeth and bones, such as mottling of teeth or skeletal fluorosis [ 6 – 9 ]. And along with teeth or skeletal fluorosis, pathological changes have also been reported in soft tissues including thyroid [ 10 ], thymus [ 11 ], brain [ 12 , 13 ], heart [ 14 , 15 ], liver [ 16 – 18 ], spleen [ 19 – 22 ], gastro-intestinal tract [ 23 , 24 ], cecal tonsil [ 25 , 26 ], bursa of Fabricius [ 27 ] and reproductive organs [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological findings of renal tissue induced by oxidative stress due to different concentrations of fluoride

et al. 2017

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It has been reported that excessive intake of fluoride can induce renal lesions. However, its pathogenesis is still less understood. Therefore, this study was conducted to investigate oxidative damage and the relationships between the oxidative damage and renal lesions in fluoride-treated mice by using the methods of histopathology, biochemistry, flow cytometry and quantitative real-time polymerase chain reaction (qRT-PCR). A total of 240 ICR mice were randomly divided into four equal groups (sodium fluoride was given orally at the dose of 0, 12, 24 and 48 mg/kg body weight for 42 days, respectively). We found that fluoride in excess of 12 mg/kg induced renal oxidative damage, which was characterized by increasing the levels of reactive oxygen species (ROS) production and contents of malondialdehyde (MDA) and protein carbonyls (PC), and decreasing the abilities of anti-superoxide anion (ASA) and anti-hydroxyl radical (AHR), glutathione (GSH) content, as well as activities and mRNA expression levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GSH-Px). Concurrently, fluoride caused degeneration and necrosis of the tubular cells, renal tubular hyaline casts and glomeruli swelling, which were consistent with the alteration of renal function parameters including elevated contents of serum creatinine (Cr), serum uric acid (UA), blood urea nitrogen (BUN), and the activities of urinary N-acetyl-b-D-glucosaminidase (NAG), renal lactate dehydrogenase (LDH), and reduced activities of sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) and acid phosphatase (ACP) in the kidney. The above-mentioned results showed that fluoride in excess of 12 mg/kg induced renal oxidative damage, which then caused renal lesions and dysfunctions. These findings also clearly demonstrated that oxidative damage is one of the mechanisms of fluoride-induced renal lesions and dysfunctions.

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“…The results indicated that children who had low height-for-age (as a consequence of inadequate nutrition) were at a higher risk for dental fluorosis. 16 …”

Section: Introductionmentioning

confidence: 99%

The prevalence of dental fluorosis and exposure to fluoride in drinking water: A systematic review

Goodarzi

Mahvi²,

Hosseini

et al. 2016

J Dent Res Dent Clin Dent Prospects

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Background. Regarding the lack of comprehensive systematic review on the efficacy of water fluoridation and prevalence of dental fluorosis, the aim of the current research was to systematically study the prevalence of dental fluorosis at different levels of water fluoride in the world and lay emphasis on the amount of fluoride in drinking water.Methods. Studies were searched in PubMed, Scopus, SID, and IranMedex, with regard to inclusion criteria. Study validity was assessed with some checklists, and analyses were performed to ascertain the prevalence of dental fluorosis among individuals categorized in age groups.Results. Investigation of the heterogeneity and analysis of the subgroups revealed that in the 6-18 year age group, when water fluoride level was less than 0.7 ppm and there was exposure to water fluoride in the first 6-8 years of life, no significant heterogeneity was detected among the studies in this subgroup. Thus, the pooled estimation of dental fluorosis prevalence in this subgroup was 12.9% (95% CI: 7.5-18.3%). Furthermore, meta-regression indicated that the exposure time to fluoride in drinking water, or exposure to fluoride in supplements, diets, air, etc as well as the quality of studies had a significant relation to the difference in the prevalence of dental fluorosis.Conclusion. The results revealed no heterogeneity in just 2 subgroups, and the results of subgroups could be pooled in them. Furthermore, the number of studies included in this review considerably decreased by considering all the detected confounding factors, whereas other similar systematic reviews mentioned at most 2 factors.

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Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico

Cited by 48 publications

References 43 publications

Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Histopathological findings of renal tissue induced by oxidative stress due to different concentrations of fluoride

The prevalence of dental fluorosis and exposure to fluoride in drinking water: A systematic review

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