Nutritional status and oxidative stress in an elderly Sardinian population

Mandas, Antonella; Congiu, Maria Gabriella; Balestrieri, Cinzia; Mereu, Antonello; Iorio, Eugenio Luigi

doi:10.1007/s12349-008-0016-1

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…High GPx activity in patients at high risk of nutrition-related complications according to the GNRI might indicate the highest level of oxidative stress in this group of patients. Both current results and previous reports indicate that there is an inverse relation between oxidative stress and the nutritional status of older patients [ 9 , 45 ]. Moreover, severe oxidative stress is linked to a presence of metabolic syndrome in older individuals [ 46 ].…”

Section: Discussionsupporting

confidence: 87%

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

et al. 2023

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Malnutrition is classified as one of the Giant Geriatric Syndromes. It carries serious consequences, such as sarcopenia or depression, which lead to functional disability. The main objective of this study was to identify parameters of oxidative stress and adipokines, which may be potential biomarkers of malnutrition in hospitalized older patients. During the study, selected parameters were determined in 137 senile patients, taking into account their nutritional status determined according to the Mini Nutritional Assessment (MNA), as well as an additional tool, namely the Geriatric Nutritional Risk Index (GNRI). Leptin and resistin were determined as the parameters with statistically significant differences between the patients classified according to the MNA. This phenomenon was confirmed using the GNRI classification. However, additional parameters for which differences were observed include the oxidized low-density lipoprotein level and activity of glutathione peroxidase. In conclusion, the determination of the mentioned markers in hospitalized senile patients as an adjunct to the routine assessment of nutritional status might be suggested to identify the early risk of malnutrition so that a personalized nutritional therapy can be implemented as early as possible.

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Section: Discussionsupporting

confidence: 87%

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

et al. 2023

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“…Malnutrition and oxidative stress. In malnutrition, oxidative stress is heightened, and impoverished nutritional status is conspicuously associated with immune dysfunction (42,43). Hepatic steatosis has also been found in the malnourished animals and humans, with a likely link to oxidative stress and mitochondrial dysfunction (44,45).…”

Section: Risk Factors Of Antituberculosis Drug-induced Hepatotoxicitymentioning

confidence: 99%

Oxidative Stress and First-Line Antituberculosis Drug-Induced Hepatotoxicity

Yew

Chang

Chan

2018

Antimicrob Agents Chemother

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Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how oxidative stress and, more broadly, disturbance in redox homeostasis alongside mitochondrial dysfunction may contribute to the hepatotoxicity induced by them. Risk factors for such toxicity that have been identified, in addition to genetic factors, principally include old age, malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection, and preexisting liver disease. Importantly, these comorbid conditions are associated with oxidative stress and drugs related to antioxidants, especially those for management of mitochondrial dysfunction. Thus, the shared pathogenetic mechanism(s) for liver injury might be in operation due to disease-drug interaction. Our current ability to predict, prevent, or treat hepatotoxicity (other than removing potentially hepatotoxic drugs) remains limited. More translational research to unravel the pathogenesis, inclusive of the underlying molecular bases, regarding antituberculosis drug-induced hepatotoxicity is needed, and so is clinical research pertaining to the advances in therapy, with antioxidants and beyond. The role of pharmacogenetics in the clinical management of drug-induced hepatotoxicity also likely merits further evaluation.

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“…27 The mean BAP in Japanese subjects was markedly higher than that previously reported in European/American subjects. 28 This may be one cause of the longevity of the Japanese. However, further epidemiological studies should be carried out to support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

et al. 2011

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In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. INTRODUCTIONOxidative stress may be involved in various disorders and pathogeneses, especially in lifestyle-related diseases, and it causes the progression and acceleration of atherosclerosis. 1-3 Biomarkers of oxidative stress, such as serum malondialdehyde level measured as thiobarbituric acid-reactive substances, oxidized low-density lipoprotein, oxidation injury of DNA, 8-hydroxydeoxyguanosine and urinary excretion of 8-iso-prostaglandin-F2a, are generally measured in laboratories. [4][5][6][7] On the other hand, as indices of antioxidant potential, intracellular levels of superoxide dismutase and glutathione peroxidase have mainly been measured. [8][9] However, these assay methods are complex and are not suitable for analysis of a large number of subjects. Recently, simpler methods for detecting reactive oxygen species (ROS) using derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were developed, and reports on studies using these methods have been increasing. [10][11][12][13][14][15][16][17][18][19][20] Thus, in the present study, we measured d-ROMS and BAP as indices for the production of ROS and antioxidant potential, respectively.

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Nutritional status and oxidative stress in an elderly Sardinian population

Cited by 6 publications

References 45 publications

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

Oxidative Stress and First-Line Antituberculosis Drug-Induced Hepatotoxicity

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

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