Nutritional status of selenium in Alzheimer's disease patients

Abstract

Studies have shown that various antioxidants are decreased in different age-related degenerative diseases and thus, oxidative stress would have a central role in the pathogenesis of many disorders that involve neuronal degeneration, including Alzheimer's disease (AD). The present study aimed to assess the nutritional status of Se in AD patients and to compare with control subjects with normal cognitive function. The case–control study was carried out on a group of elderly with AD (n 28) and compared with a control group (n 29), both aged between 60 and 89 years. Se intake was evaluated by using a 3-d dietary food record. Se was evaluated in plasma, erythrocytes and nails by using the method of hydride generation atomic absorption spectroscopy. Deficient Se intake was largely observed in the AD group. AD patients showed significantly lower Se levels in plasma, erythrocytes and nails (32·59 μg/l, 43·74 μg/l and 0·302 μg/g) when compared with the control group (50·99 μg/l, 79·16 μg/l and 0·400 μg/g). The results allowed us to suggest that AD has an important relation with Se deficiency.

Sigara İçme ve Alzheimer Hastalığı Arasındaki İlişki

“…Further, this deficiency in smokers maybe enhanced by their generally lower intake of both supplementary and dietary antioxidants 167 .…”

Sodyum selenat’ın XRD, PSD, DSC, TGA/DTG, UV-VIS ve FT-IR yöntemleri ile fizikokimyasal, termal ve spektroskopik karakterizasyonu

“…Selenium (Se) was investigated and observed to have the capability to delay the Alzheimer's symptoms as well as the initiation of skin aging (4,5). It also protects various enzymes against the heavy metals toxicity such as Pb, Al, Cu, and Cd (6).…”

“…It also protects various enzymes against the heavy metals toxicity such as Pb, Al, Cu, and Cd (6). Various other role of selenium on investigation found as an antioxidant (7), anti-cancer (8), and heart disease (4). Sodium selenate has the other applications in glass (8), pesticide, and some fungicides (9, 10) manufacturing industries.…”

Evaluation of the Physicochemical, Spectral, Thermal and Behavioral Properties of Sodium Selenate After the Energy of Consciousness Healing Treatment

“…Selenium is an essential trace element, which has been reported to postpone the Alzheimer's symptoms in the elderly people and delay the initiation signs of skin aging [2,3]. Recent studies have shown that this compound protects various enzymes against the toxicity caused by heavy metals i.e.…”

“…The role of selenium in biological systems have been investigated over the years to demonstrate the effects of selenium, for example, it helps to promote a healthy liver, acts as an antioxidant [5], prevent cancers [6], normal metabolic reactions [7] and heart disease [2]. It was also known to provide protection from reactive oxygen species-induced cell damages [2,3]. Sodium selenate has various other applications in the glass industry [8], an ingredient in some insecticides (against mites, aphids, and mealybugs) and fungicides [9,10].…”