Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial

Marchesini, Giulio; Bianchi, Giampaolo; Merli, Manuela; Amodio, Piero; Pañella, C.; Loguercio, C.; Fanelli, Filippo Rossi; Abbiati, R.

doi:10.1016/s0016-5085(03)00323-8

Cited by 543 publications

(415 citation statements)

References 35 publications

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“…Clinical data indicate that BCAA supplementation reduces the incidence of anorexia in cancer and malnourished patients and in patients with liver cirrhosis (Cangiano et al, 1996;Hiroshige et al, 2001;Marchesini et al, 2003;Laviano et al, 2005Laviano et al, , 2006Biolo et al, 2006). In a placebocontrolled multi-center trial in cirrhotic patients (n ¼ 174), 1 year supplementation with BCAA resulted in a decreased prevalence of anorexia from 52 to 25%, whereas anorexia prevalence remained unchanged in the control group (Marchesini et al, 2003). The incidence of anorexia also decreased in the BCAA supplemented group, whereas it did not change in the placebo group in a study in cachectic cancer patients supplemented with 14.4 g/day BCAA (7.1 g leucine) (Cangiano et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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Cancer cachexia is characterised by metabolic alterations leading to loss of adipose tissue and lean body mass and directly compromises physical performance and the quality of life of cancer patients. In a murine cancer cachectic model, the effects of dietary supplementation with a specific combination of high protein, leucine and fish oil on weight loss, muscle function and physical activity were investigated. Male CD2F1 mice, 6 -7 weeks old, were divided into body weight-matched groups: (1) control, (2) tumourbearing, and (3) tumour-bearing receiving experimental diets. Tumours were induced by s.c. inoculation with murine colon adenocarcinoma (C26) cells. Food intake, body mass, tumour size and 24 h-activity were monitored. Then, 20 days after tumour/ vehicle inoculation, the animals were killed and muscle function was tested ex vivo. Tumour-bearing mice showed reduced carcass, muscle and fat mass compared with controls. EDL muscle performance and total daily activity were impaired in the tumour-bearing mice. Addition of single nutrients resulted in no or modest effects. However, supplementation of the diet with the all-in combination of high protein, leucine and fish oil significantly reduced loss of carcass, muscle and fat mass (loss in mass 45, 52 and 65% of TB-con, respectively (Po0.02)) and improved muscle performance (loss of max force reduced to 55 -64% of TB-con (Po0.05)). Moreover, total daily activity normalised after intervention with the specific nutritional combination (50% of the reduction in activity of TB-con (Po0.05)). In conclusion, a nutritional combination of high protein, leucine and fish oil reduced cachectic symptoms and improved functional performance in cancer cachectic mice. Comparison of the nutritional combination with its individual modules revealed additive effects of the single components provided.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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“…Long-term BCAA treatment in patients with liver cirrhosis improved event-free survival time and quality of life in several randomized trials. 21,22 Furthermore, long-term oral supplementation with BCAA granules inhibits liver carcinogenesis in overweight and obese patients with liver cirrhosis. 9 Long-term administration of BCAA improves insulin resistance 15 and inhibits VEGF production, 23 which may therefore inhibit carcinogenesis.…”

Section: Effect Of Branched Chain Amino Acids On Diethylnitrosamine-imentioning

confidence: 99%

Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats

Ishizaki

Nishiyama

Hagiwara

2013

Journal of Clinical and Experimental Hepatology

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Background: Obesity increases the risk of fatty liver disease and liver cancer. There are several models of obesityassociated hepatocellular carcinoma, but tumor development in these models is slow. Materials and methods: We investigated Zucker fatty rats, a model of obesity and insulin resistance, to discover if diethylnitrosamine (DEN), a potent liver carcinogen, might enhance liver carcinogenesis. We also investigated the effect of branched chain amino acids (BCAA) against the development of liver cancer. Results: Incidence and number of hepatocellular carcinomas and adenomas were significantly greater in DEN-treated Zucker fatty rats than in DEN-treated lean rats. All treated Zucker fatty rats developed hepatocellular carcinoma within 16 weeks. Long-term BCAA supplementation significantly reduced expression of CyclinD1, PCNA, thymidine kinase, Bcl-2, and GST-p and increased expression of p21 in the liver. Furthermore, BCAA treatment significantly reduced the area of GST-p positive foci. Conclusion: Long-term BCAA treatment may induces cell cycle arrest and apoptotic induction, thus suppressing pre-neoplastic lesions. ( J CLIN EXP HEPATOL 2013;3:192-197)

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“…Por otra parte, los preparados nutricionales ricos en aminoácido de cadena ramificada pueden ser útiles en pacientes con EH crónica. Sus efectos anabó-licos y energéticos a nivel muscular podrían favorecer una disminución del amoniaco y un mejor curso clínico (46). Durante el episodio de EH aguda suele ser necesario evitar la vía oral debido a la disminución de la conciencia.…”

Section: Medidas Dietéticasunclassified

Actualización en el tratamiento de la encefalopatía hepática

Martínez¹,

Cardona²

2008

Rev. esp. enferm. dig.

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Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial

Cited by 543 publications

References 35 publications

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats

Actualización en el tratamiento de la encefalopatía hepática

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