AP, MG, JCT and YLB supervised this work. JCT, YLB, MR, MG and AP contributed to design the experiment. AM and MG contributed to sample handling and collection and sample biobanking. MG achieved endocrine phenotyping and curation. CC and JM performed metabolomic analyses. FXL, BL and AP performed statistical analyses. CC did an expert-based assignment of putative biomarkers. AP performed the data interpretation and wrote the manuscript. JCT, YLB, MG, MR, CC, FXL and BL revised the manuscript. All authors have read and approved the manuscript.