Nutritional support and bronchopulmonary dysplasia

Young, Thomas E.

doi:10.1038/sj.jp.7211725

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…A paternal history of TCDD exposure also increased the offspring's risk of new BPD, a disease previously associated with prematurity, IUGR, and placental dysfunction [19,21,22,57]. The severity of new BPD worsened in neonatal mice that received supplemental formula, although this dietary intervention is commonly provided to premature human infants to enhance their nutritional intake and promote lung development [29,58,59]. Intervening with a paternal fish oil diet preconception, following his own in utero TCDD exposure, reduced the risk of premature birth and IUGR in offspring in association with improved placental function [18].…”

Section: Discussionmentioning

confidence: 99%

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Rumph

Rayford

Stephens

et al. 2021

Toxics

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New bronchopulmonary dysplasia is a developmental lung disease associated with placental dysfunction and impaired alveolarization. Risk factors for new BPD include prematurity, delayed postnatal growth, the dysregulation of epithelial-to-mesenchymal transition (EMT), and parental exposure to toxicants. Our group previously reported that a history of paternal toxicant exposure increased the risk of prematurity and low birth weight in offspring. A history of paternal toxicant exposure also increased the offspring’s risk of new BPD and disease severity was increased in offspring who additionally received a supplemental formula diet, which has also been linked to poor lung development. Risk factors associated with new BPD are well-defined, but it is unclear whether the disease can be prevented. Herein, we assessed whether a paternal fish oil diet could attenuate the development of new BPD in the offspring of toxicant exposed mice, with and without neonatal formula feeding. We investigated the impact of a paternal fish oil diet preconception because we previously reported that this intervention reduces the risk of TCDD associated placental dysfunction, prematurity, and low birth weight. We found that a paternal fish oil diet significantly reduced the risk of new BPD in neonatal mice with a history of paternal toxicant exposure regardless of neonatal diet. Furthermore, our evidence suggests that the protective effects of a paternal fish oil diet are mediated in part by the modulation of small molecules involved in EMT.

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Section: Discussionmentioning

confidence: 99%

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Rumph

Rayford

Stephens

et al. 2021

Toxics

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“…When the growth of exclusively breastfed BPD infants is poor, postdischarge formulas may be an option [138,139], alternating with breastfeeding or in place of breastfeeding. Postdischarge formulas are enriched with energy and nutrients designed for short-to medium-term use in healthy preterm infants after discharge, and their energy and nutrient content is in between that of preterm formulas and term formulas [136].…”

Section: Nutrition After Dischargementioning

confidence: 99%

The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach

Rocha

Guimarães

Pereira‐da‐Silva

2021

IJERPH

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Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth, and nutrition plays a crucial role in lung growth and repair. A practical nutritional approach for infants at risk of BPD or with established BPD is provided based on a comprehensive literature review. Ideally, infants with BPD should receive a fluid intake of not more than 135‒150 mL/kg/day and an energy intake of 120‒150 kcal/kg/day. Providing high energy in low volume remains a challenge and is the main cause of growth restriction in these infants. They need a nutritional strategy that encompasses early aggressive parenteral nutrition and the initiation of concentrated feedings of energy and nutrients. The order of priority is fortified mother’s own milk, followed by fortified donor milk and preterm enriched formulas. Functional nutrient supplements with a potential protective role against BPD are revisited, despite the limited evidence of their efficacy. Specialized nutritional strategies may be necessary to overcome difficulties common in BPD infants, such as gastroesophageal reflux and poorly coordinated feeding. Planning nutrition support after discharge requires a multidisciplinary approach to deal with multiple potential problems. Regular monitoring based on anthropometry and biochemical markers is needed to guide the nutritional intervention.

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“…Несмо-тря на то что витамин Е является мембраностаби-лизатором, стимулирует продукцию антител за счет подавления функции Т-супрессоров, нормализует состояние клеточного и гуморального иммунитета и повышает фагоцитарную активность нейтрофи-лов [7], его назначение недоношенным детям не вы-явило значимого положительного влияния на разви-тие БЛД [50].…”

Section: фа к торы риск а и пре дик торы бронхолегочной дисп ла зииunclassified

“…Снижение потребления энерге-тических субстратов в первые 21 день жизни при-водило к уменьшению числа альвеол и снижению синтеза сурфактанта. Имеются данные о повышен-ных энергетических затратах на окисление глюкозы у детей с БЛД, получавших исключительно «обез-жиренное» внутривенное питание [50]. Фактором риска является и введение больших объемов жид-кости, которое ассоциируется с персистирующим ОАП и отеком легких [14].…”

Section: фа к торы риск а и пре дик торы бронхолегочной дисп ла зииunclassified

Risk factors, predictors and contemporary diagnostics of bronchopulmonary dysplasia

et al. 2017

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Improving of resuscitation and intensive care of premature babies allowed their survival. Bronchopulmonary dysplasia (BPD) is the significant complication of low-birth newborns. Identification of early predictors of disease can optimize of treatment and decrease of quantity of appearance and severity of BPD. Quantity of BPD is 5-97%. The significant predictors from hereditary and genetic factors are family bronchopulmonary pathology, dysplasia of connective tissue, gene polymorphism of VEGF, EPNX-113 Hiss, Nos3-786C, GCLC, 58 Т/С sod2, minore allele - 460 of T-gene (VEGF); from clinical and immunological factors - lung immaturity, alveolarization and vascularization disorders, hemodynamically significant ductus arteriosus; from biochemical factors - hyperoxy, lipid peroxidation and decreasing of antiperoxidation, disorder of angiotensin-1/endostatin; from therapeutic factors - overexertion of lungs during ventilation, avoiding of antiperoxid protection, insufficiency of nutrition. Contemporary methods of BPD diagnostic are clinical data (oxygen dependence at 28 days after birth), X-ray sings, identified by X-ray examination and tomography and bronchophonography. More of identified factors and predictors of BPD are difficult for examinations, haven’t 100% result or low predictive power, that is why further study is needed.

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Nutritional support and bronchopulmonary dysplasia

Cited by 9 publications

References 23 publications

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

The Role of Nutrition in the Prevention and Management of Bronchopulmonary Dysplasia: A Literature Review and Clinical Approach

Risk factors, predictors and contemporary diagnostics of bronchopulmonary dysplasia

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