“…Although there is no de nite evidence of brain damage associated with plasma glucose levels in this range, the data mentioned above indicate that it is probably not providing optimal conditions for brain development, especially in compromised neonates. If all the uncertain factors surrounding neonatal hypoglycemia and glucose measurements are taken into consideration, an operational threshold of 2.5 mmol/L, as has previously been suggested (16), seems prudent while awaiting reliable continuous glucose monitoring equipment that is feasible in routine clinical practice.…”