Interspecific hybrids called hybrids are individuals obtained by crossing two different species. Hybrids are found both in nature among wild animals but also have become attractive in animal husbandry due to the high production features of the F1 generation. Interspecific hybrids are observed in nature most often as a result of crossing closely related species, which is a great danger to the purity of the population of starting species. Interspecies hybrids are also created by man for production purposes. Due to disturbances in gametogenesis processes, they have become a valuable research model. In the article, we describe interspecific hybrids occurring in nature and related problems, interspecific hybrids created for production purposes in animal husbandry, but also research using hybrids as a research model. In the article we also highlight the issues of fertility of individuals obtained from such matings.