Nutritive value of the chebulic myrobalan (Terminalia chebula Retz.) and its potential as a food source

Arulselvan

JOURNAL OF HEALTH SCIENCE

et al. 2006

175

The present study was aimed to evaluate the anti-diabetic potential of Terminalia chebula (T. chebula) fruits on streptozotocin (STZ)-induced experimental diabetes in rats. Oral administration of ethanolic extract of the fruits (200 mg/kg body weight/rat/day) for 30 days significantly reduced the levels of blood glucose and glycosylated hemoglobin in diabetic rats. Determination of plasma insulin levels revealed the insulin stimulating action of the fruit extract. Also, the alterations observed in the activities of carbohydrate and glycogen metabolising enzymes were reverted back to near normal after 30 days of treatment with the extract. Electron microscopic studies showed significant morphological changes in the mitochondria and endoplasmic reticulum of pancreatic β cells of STZinduced diabetic rats. Also, a decrease in the number of secretory granules of β-cells was observed in the STZinduced diabetic rats and a these pathological abnormalities were normalized after treatment with T. chebula extract. The efficacy of the fruit extract was comparable with glibenclamide, a well known hypoglycemic drug.

Section: )mentioning

confidence: 99%

Anti-Diabetic Activity of Fruits of Terminalia chebula on Streptozotocin Induced Diabetic Rats

Arulselvan

JOURNAL OF HEALTH SCIENCE

et al. 2006

175

Cell Biochemistry & Function

“…13 T. chebula is one of the ingredients in popular ayurvedic formulation of Triphala. The important active principle constituents of T. chebula are chebulagic, chebulinic acid, corilagin, 14 16 In our previous studies, T. chebula has proven in vitro free radical scavenging 17 and in vivo properties. [18][19][20][21] In the present study we investigated the effect of T. chebula aqueous extract on mitochondrial antioxidant defense and macromolecular damage in the liver and kidney of aged rats compared with young rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats

Mahesh

Bhuvana

Begum

2009

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers. In the liver and kidney of aged animals, enhanced oxidative stress was accompanied by compromised antioxidant defences. Administration of aqueous extract of T. cheubla effectively modulated oxidative stress and enhanced antioxidant status in the liver and kidney of aged rats. The results of the present study demonstrate that aqueous extract of T. cheubla inhibits the development of age-induced damages by protecting against oxidative stress.

“…The fruits are hard stony drupe, greenish yellow in color, odorless, ovate, longitudinally wrinkled, and 3.5 to 4.0 cm in length. It is a popular folk medicine and has been studied for its homeostatic laxative, diuretic, and cardiotonic activities (Singh, 1990;Barthakur et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Potential ofTerminalia chebula. Fruits Studied in Streptozotocin-Induced Diabetic Rats

Senthilkumar

Subramanian

2007

Pharmaceutical Biology

Oxidative stress is believed to be a pathogenic factor in the development of diabetic complications. Recently, we have reported the antidiabetic activity of Terminalia chebula Retz. (Combretaceae) fruits on streptozotocin (STZ)-induced experimental diabetes. The current study was aimed to evaluate the antioxidant potential of Terminalia chebula fruits on STZ-induced diabetic rats. Oral administration of ethanol extract of Terminalia chebula fruit at a concentration of 200 mg=kg body weight for 30 days significantly controlled the alteration in the levels of thiobarbituric acid reactive substances, hydroperoxides, and both enzymatic and nonenzymatic antioxidants. In addition, the treatment also resulted in a significant decrease in the levels of blood glucose and glycosylated hemoglobin. The results are comparable with glibenclamide, a known hypoglycemic drug. The presence of biologically active ingredients in the fruit extract may be responsible for the antioxidant properties of the Terminalia chebula fruits, which in turn may be partially responsible for its antidiabetogenic properties.