Nuts and bolts of PMMC flap in oral cancer and its clinical outcome in 168 indian patients: A retrospective analysis

Girhe, Vijaykumar; Auti, Akanksha A.; Girhe, Prachi; Wagre, Rohinee

doi:10.1016/j.jobcr.2021.02.003

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Therefore, a large number of patients have postoperative maxillofacial deformities, which may lead to the loss of speech, chewing, taste, or other basic functions (Sun et al, 2020). Despite the development of modern medicine, we can repair excised soft tissues with vascularly anastomosed musculocutaneous flap grafts (Girhe et al, 2021), but the appearance and function after the repair are still unsatisfactory. The failure of radiotherapy to target cancer cells leads to non-specific cell death, and many patients experience complications such as mucositis, osteomyelitis, mouth ulcers, and rampant dental caries (Minhas et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer

Yin

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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A novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives: loading of chemotherapeutic agents, active targeting, pH responsiveness, and prolonged in vivo blood circulation. DOX-loaded polymeric nanoparticles (DOX/H20-PLA@PDA NPs) were functionalized with amino-poly (ethylene glycol)-folic acid (H2N-PEG-FA) after coating them with PDA to form the targeting combination, DOX/H20-PLA@PDA-PEG-FA NPs. The novel NPs exhibited drug delivery characteristics similar to DOX/H20-PLA@ PDA NPs. Meanwhile, the incorporated H2N-PEG-FA contributed to active targeting, as illustrated in cellular uptake assays and animal studies. In vitro cytotoxicity and in vivo anti-tumor studies have shown that the novel nanoplatforms exhibit extremely effective therapeutic effects. In conclusion, the multifunctional PDA-modified H20-PLA@PDA-PEG-FA NPs offer a promising chemotherapeutic strategy to improve the treatment of oral cancer.

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Section: Introductionmentioning

confidence: 99%

Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer

Yin

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Versatility of the myocutaneous pectoralis major flap in oncology reconstruction: A literature review and practical application

Vasques,

Kwiatkowski,

Kwiatkowski

et al. 2024

Journal of Surgical Oncology

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Pectoralis major muscle flaps are considered versatile and allow large reconstructions of anatomical defects within a single surgical procedure. Considered a “workhorse” due to these characteristics, the pectoralis major muscle is an excellent option for surgical reconstruction. Several uses of this flap are described in the literature, such as protection of the jugulocarotid system after cervical lymph node dissection, oral, cervical, breast, diaphragmatic, hypopharyngeal, pharyngeal, laryngeal, and esophageal reconstructions.

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Pedicled thoracoacromial artery compound flaps for circumferential hypopharyngeal reconstruction

Wang

et al. 2023

Eur Arch Otorhinolaryngol

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Nuts and bolts of PMMC flap in oral cancer and its clinical outcome in 168 indian patients: A retrospective analysis

Cited by 3 publications

References 10 publications

Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer

Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer

Versatility of the myocutaneous pectoralis major flap in oncology reconstruction: A literature review and practical application

Pedicled thoracoacromial artery compound flaps for circumferential hypopharyngeal reconstruction

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