Nystagmus and Lower Extremity Hyperalgesia After Colectomy

Vogrig, Alberto; Zanoni, Tiziano; Moretto, Giuseppe

doi:10.1001/jama.2016.13658

Cited by 7 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wernicke encephalopathy is a neurological disorder resulting from the deficiency of thiamine, and is commonly related to the chronic abuse of alcohol[ 1 , 2 ]. Recently, the incidence of non-alcoholic Wernicke encephalopathy has been increasing, and malignancy is one of the attributable causes.…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic Wernicke encephalopathy in an esophageal cancer patient receiving radiotherapy: A case report

Zhang¹,

Wang²,

Jang³

et al. 2022

WJCC

View full text Add to dashboard Cite

BACKGROUND Wernicke encephalopathy is a rare but potentially fatal adverse event caused by thiamine deficiency. Reports of non-alcoholic Wernicke encephalopathy due to malignancy are scarce in the literature, with those reported mainly being on haematological cancer, followed by gastrointestinal cancer. As a result, there is considerable under-recognition and delay in the diagnosis and treatment of Wernicke encephalopathy in oncology departments. To our knowledge, there has been no report of Wernicke encephalopathy in a patient with esophageal cancer while receiving radiotherapy. CASE SUMMARY A 64-year-old man presented to the oncology outpatient clinic with a history of dysphagia for 2 mo, and was diagnosed with locally advanced esophageal squamous cell carcinoma (stage IIIB). Radiotherapy was initiated to alleviate dysphagia due to malignant esophageal stenosis; however, the patient exhibited consciousness disturbances starting on day 10 of radiotherapy. Brain magnetic resonance imaging indicated the development of Wernicke encephalopathy. Subsequent treatment with thiamine led to rapid improvement in the patient’s neurological symptoms. CONCLUSION Wernicke encephalopathy may develop in non-alcoholic patients undergoing radiotherapy for esophageal cancer. Early diagnosis and sufficient thiamine supplementation during radiotherapy are essential.

show abstract

Section: Discussionmentioning

confidence: 99%

Non-alcoholic Wernicke encephalopathy in an esophageal cancer patient receiving radiotherapy: A case report

Zhang¹,

Wang²,

Jang³

et al. 2022

WJCC

View full text Add to dashboard Cite

show abstract

“…The localizing value of ocular motor findings was emphasized in a patient with conjugate ipsilesional eye deviation and spontaneous horizontal nystagmus beating contralesionally in lateral medullary infarction [51]. Sub-acute onset of upbeat nystagmus and gaze-evoked nystagmus in combination with neurocognitive deficits and neuropathy after bariatric surgery should raise a high suspicion of Wernicke encephalopathy and prompt immediate treatment with parenteral thiamine [52].…”

Section: Nystagmus In the Differential Diagnosismentioning

confidence: 99%

Nystagmus

Tarnutzer

Straumann

2018

Current Opinion in Neurology

View full text Add to dashboard Cite

In clinical practice, a structured description of nystagmus including its three-dimensional beating direction, trigger factors and duration is of major importance. The differential diagnosis of downbeat nystagmus is broad and includes acute intoxications, neurodegenerative disorders and cerebrovascular causes amongst others. In patients with positional nystagmus, the distinction between frequent benign peripheral and rare but dangerous central causes is imperative.

show abstract