Nystagmus in pediatric patients: interventions and&amp;nbsp;patient-focused perspectives

Penix, Kimberly; Swanson, Mark W.; DeCarlo, Dawn K.

doi:10.2147/opth.s62786

Cited by 17 publications

(7 citation statements)

References 77 publications

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“…When the start of nystagmus is after three months, is not associated with an underlying sensory deficiency, or is associated with optic nerve hypoplasia, neuroimaging should be examined. 16,17 Vision-specific health-related quality of life in children with vision impairment is poorly understood. The few studies that do exist have evaluated groups of children with diverse causes of vision impairment, of which only some are associated with nystagmus.…”

Section: Discussionmentioning

confidence: 99%

Nystagmus in Childhood: A Systematic Review

Ratu Alicia

2023

JARMHS

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Nystagmus is an involuntary rhythmic oscillation of the eyes that results in decreased visual acuity owing to the excessive motion of pictures on the retina. This is because nystagmus causes the eyes to move in a repetitive pattern. It is of the utmost importance to differentiate infantile nystagmus from acquired nystagmus. In order to accomplish this, it is necessary to take into consideration not only the time at which the nystagmus first appeared, but also the features of its waveform. Oscillations of the eyes that are involuntary, often conjugate, and frequently rhythmic are referred to as nystagmus. Infantile nystagmus syndrome (INS) is the condition that accounts for the majority of cases of nystagmus in children. Because this ailment can last a person's entire life, it is essential that they are familiar with all of the treatment choices that are at their disposal. The primary foci of this review are the underlying etiology of nystagmus, the psychosocial and functional implications of nystagmus, and the current methods of treatments, which include optical, pharmacological, surgical, and rehabilitative treatment approaches. At this time, the brain mechanisms that are responsible for INS are not completely known. The evidence is limited to mostly pre- and post-study designs, and there are few objective comparisons of treatment procedures. The treatment choices are meant to increase the foveation length or correct abnormal head positions. Individualized management of INS should be implemented. The patient and the patient's physician are the ones who should make the decision regarding which treatment will be most beneficial for the patient in question.

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Section: Discussionmentioning

confidence: 99%

Nystagmus in Childhood: A Systematic Review

Ratu Alicia

2023

JARMHS

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“…Nystagmus has an estimated prevalence of 6.72 per 100,000 for individuals younger than 19 years ( 27 ). Idiopathic congenital nystagmus is associated with significant negative psychosocial and functional consequences, including negative social stigma and poor visual function scores ( 28 , 29 ). There is a great interest in the treatment and early diagnosis of idiopathic congenital nystagmus.…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p.G296C, in the FRMD7 gene

et al. 2018

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Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our understanding of its molecular pathogenesis. In the present study, direct sequencing using gene specific primers was performed in order to identify the causative mutations in two brothers from a Chinese family who had been diagnosed with idiopathic congenital nystagmus. A comprehensive ophthalmological examination, including eye movement recordings, fundus examination, and retinal optical coherence tomography imaging was also conducted, to characterize the disease phenotype. The results revealed that the two brothers exhibited clear signs of nystagmus without any other ocular anomalies. Direct sequencing revealed a G to T transition (c.886G>T) in exon 9 of the four-point-one, ezrin, radixin, moesin domain-containing 7 (FRMD7) gene, which resulted in a conservative substitution of glycine to cysteine at codon 296 (p.G296C), leading to idiopathic congenital nystagmus in the two affected brothers. c.886G>T is a novel idiopathic congenital nystagmus-inducing mutation in the FRMD7 gene. This finding expands the spectrum of known gene mutations in idiopathic congenital nystagmus, and may be useful for faster gene diagnosis, prenatal testing, the development of potential gene therapies, and for improving the understanding of the molecular pathogenesis of idiopathic congenital nystagmus.

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“…The most common types of nystagmus seen in children are infantile nystagmus syndrome, fusional maldevelopment syndrome, and spasmus nutans. [ 36 ] Outcomes in cases of nystagmus has also improved significantly with the augmented Andersons procedure[ 37 ] in shifting the eccentric null to the primary position and also evaluating the auditory biofeedback. [ 38 ] Perceptual learning has been shown to improve visual acuity in children with infantile nystagmus.…”

Section: Nystagmusmentioning

confidence: 99%

What's new for us in strabismus?

Sharma

Gaur

Phuljhele

et al. 2017

Indian J Ophthalmol

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Strabismus is one of the most challenging subspecialties encountered in the field of ophthalmology. The concept of etiology of strabismus is being advanced with the development of newer imaging modalities and increased understanding of the genetics of strabismus. Imaging is also being used to aid in the planning of strabismus surgery. Newer horizons are being explored in the amblyopia management. The good old eye-pad is being replaced with the iPad. Early detection of loss of stereopsis is being used to decide the timing for strabismus surgery. Improvement of binocular summation has been discovered as a benefit of corrective strabismus surgery. Newer surgical techniques such as new transposition procedures are being developed to correct complex strabismus. Strabismus surgeries aided by adjustable sutures have increased the precision of a strabismologist. A new light has been thrown on the psychosocial impact of strabismus. A present-day strabismologist has advanced from the goal of ocular alignment to a bigger perspective “to regain the paradise lost: stereopsis.”

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Nystagmus in pediatric patients: interventions and patient-focused perspectives

Cited by 17 publications

References 77 publications

Nystagmus in Childhood: A Systematic Review

Nystagmus in Childhood: A Systematic Review

Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p.G296C, in the FRMD7 gene

What's new for us in strabismus?

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